Young Leaders Research Articles

Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progression

Cancer cell plasticity is the ability of neoplastic cells to alter their identity and acquire new biological properties under microenvironmental pressures. In prostate cancer (PCa), lineage plasticity often results in therapy resistance and trans-differentiation to neuroendocrine (NE) lineage. However, identifying the cancer cells harboring lineage plasticity-related status remains challenging. Based on 13 multi-center human PCa bulk transcriptomic cohorts (samples=3314) and 9 bulk transcriptomic datasets derived from PCa experimental models, we established an integrated lineage plasticity-related gene signature, termed LPSig. Leveraging this gene signature, AUCell enrichment analysis was applied to identify the cell population with high lineage plasticity from a comprehensive single-cell RNA-sequencing (scRNA-seq) meta-atlas assembled by us, which consisted of 10 public human PCa scRNA-seq datasets (samples=93, cells=222,529). Moreover, additional scRNA-seq dataset of human PCa, multiplex immunohistochemistry staining for human PCa tissues, invitro and invivo functional experiments, as well as qPCR and Western blot analyses were employed to validate our findings. We found that LPSig could finely capture the dynamics of tumor lineage plasticity throughout the progression of PCa, accurately estimating the status of lineage plasticity. Based on LPSig, we identified a previously undefined minority population of lineage plasticity-related PCa cells (LPCs) from the human PCa scRNA-seq meta-atlas assembled by this study. Furthermore, in-depth dissection revealed pivotal roles of LPCs in trans-differentiation, tumor recurrence, and poor patient survival during PCa progression. Furthermore, we identified HMMR as a representative cell surface marker for LPCs, which was validated using additional scRNA-seq datasets and multiplexed immunohistochemistry. Moreover, HMMR was transcriptionally inhibited by androgen receptor (AR), and was required for the aggressive adenocarcinoma features and NE phenotype. Our study uncovers a novel population of lineage plasticity-related cells with low AR activity, stemness-like traits, and elevated HMMR expression, that may facilitate poor prognosis in PCa. This work was supported by National Key R&D Program of China (2022YFA0807000), National Natural Science Foundation of China (82160584), Advanced Prostate Cancer Diagnosis and Treatment Technology Innovation Team of Kunming Medical University (CXTD202216), and Reserve Talents of Young and Middle-aged Academic Leaders in Yunnan Province (202105AC160013).

Assessing innovative and responsive young leaders in public service: Lens from community clientele

Youth leadership brings new perspectives, innovative ideas, and a dynamic approach to addressing contemporary issues. Young leaders often possess a deep understanding of the unique challenges and opportunities faced by their generation, enabling them to develop solutions that are relevant and impactful. Their involvement in public service fosters a sense of responsibility and civic engagement, encouraging a culture of active participation and community building. This study examined the innovative and responsive characteristics of young leaders in the Philippines. This exploratory paper expected to provide understanding on how community clientele like community residents, elderly people, persons with disability, perceived innovative and responsive traits of community youth leaders. Convenience sampling (n=12) was carried out to select the participants seeking assistance from barangays leaders. Findings indicated that the community clienteles described these young leaders as possessing creative minds capable of ‘thinking outside the box’ to address evolving challenges and meet community needs. Youth leaders were noted for their commitment to effective communication, gathering feedback, and working collaboratively with the community to resolve issues. They are accessible and approachable, demonstrating empathy and attentiveness to the concerns of those they serve. The perception of community clientele emphasized how young leaders integrate creative and innovative approaches to problem-solving with proactive and empathetic engagement to the community, and their commitment to transparency and effective communication. These qualities collectively contribute to the community's positive view of youth leadership, recognizing the potential of young leaders to bring about meaningful and lasting change.

APJS-4 JSMO-Rising Stars in Asia Workshop – initiatives for cultivating young Asian leaders and international exchange

APJS-4 JSMO-Rising Stars in Asia Workshop – initiatives for cultivating young Asian leaders and international exchange

Climate Action and the UNCRC: A ‘Postpaternalist’ World Where Children Claim Their Own Rights

In this paper, it is argued that we are in a ‘postpaternalist’ era for children’s rights, involving grassroots action from children (for the first time, on a global scale) rather than well-meaning adults ‘giving’ children their rights. Child/youth climate action has involved under-18s acting for the environment through grassroots protest, media work and lobbying. The UN Convention on the Rights of the Child (CRC) has arguably to date been approached in a paternalist way, whereby children need adults to help them to access rights. Yet, child/youth climate advocates have taken their own action, and demand equality as they enter rights spaces. They are frequently working with adults as equals and allies in litigating climate cases, for example. It is argued that (although there are rights challenges in a postpaternalist time) these young rights leaders have transformed human rights for the better, and adults should facilitate their work in a way that is child- and youth-friendly.

Pemimpin yang Baik Dalam Organisasi : Pelatihan Kepemimpinan (LDKM 2023) Dari Psychological View

This article was prepared to share insights, perspectives and knowledge through lectures and training for prospective young leaders in organizations, within the framework of Basic Student Leadership Training (LKDM) activities. In the 2023 LDKM setting, students consist of various study programs who will be appointed as candidates to become administrators of HIMA Study Programs and Faculties at Ma'soem University. The material is given in the form of presentations with tutorials to discussions and implementation in cases of leadership within campus organizations. As a result of this service, participants from LDKM 2023 activities gain new insight and knowledge so that in the process they will personalize this in organizational activities and even in their daily lives.

The Young Leader’s Dilemma: Facing Implicit and Explicit Age Bias in Leadership Roles

The Young Leader’s Dilemma: Facing Implicit and Explicit Age Bias in Leadership Roles

Understanding Rural – Urban Migration in Uganda’s Refugee Camps Authors

With continued conflicts all over the world, more refugees will continue migrating to countries they consider safe. According to Konrad-Adenauer-Stiftung and Young Leaders Think Tank (2017), refugees prefer dwelling in urban areas, which can be attributed to the global urbanisation phenomenon. This paper examines the factors influencing rural-urban migration to inform refugee management in urban settings. According to the Office of the Prime Minister, Uganda Refugee Statistics of September 2023, Uganda was host to over 1.5 million refugees, mainly from, South Sudan, the Democratic Republic of Congo, Somalia, Burundi, Eritrea and Rwanda. These refugees are registered in the rural settlements (refugee camps) as provided for by Uganda’s legal framework on the management of refugees, which framework also only recognises refugees in the capital Kampala as urban refugees. However, the landscape has evolved as some refugees have self-settled in various urban centres across Uganda, rapidly increasing the urban population and stressing urban services. Our study findings in Koboko Municipality show various personal, push and pull factors responsible for the refugees’ decision for rural-urban migration. These factors relate to demographic age, education level, gender, better social services, payable employment, economic activities, and utilisation of skills among others. The findings signal the need to recognise and plan for urban refugees in urban areas other than Kampala City. Urbanisation is a factor in refugee management in Uganda. Keywords: Urban refugee, Rural-urban migration, Koboko municipality, Uganda

Exploring Alternative Futures Focusing on the Science and Technology Policy of Kim Jong‐un's Regime*

Science and technology policy of Kim Jong‐un's regime in North Korea is more strategic and aggressive than ever before. Under the tight economic sanctions led by the United States and its partners, the young leader makes a desperate effort to boost science and technology (S&T) for maintaining North Korea's political stability and achieving economic development. Despite growing concerns over nuclear and security issues, studies addressing the alternative futures of North Korea are mainly focused on the economy, nuclear weapons, and stability of the regime. This study explores various alternative futures for North Korea's S&T policy, which are different from the viewpoints of most existing studies. To envision and propose alternative futures for North Korea's S&T policy in 2050, we try to link uncertainty levels and types of futures based on Voros' future types and utilize Dator's alternative future model. Based on alternative futures, this study suggests a new perspective to better understand the plausible futures of S&T policies and strategies for a preferable future of the country.

Discover Early Career and Young Leader Opportunities through TMS

Discover Early Career and Young Leader Opportunities through TMS

The impact of digitalization on forming modern youth political leadership

Youth political engagement is a crucial aspect of modern society. In this regard, digitalization opens huge communicative and mobilization opportunities by transforming young people’s political participation into a digital format with unpredictable consequences. The article analyzes digitalization impact as a complex multi-stage process in modern world on forming youth political leadership. The essence and stages of digitalization, the consequences of digital technologies impact on society, political processes, and youth environment have been studied. The transformational impact on socialization, communicative culture and self-consciousness of youth as a fundamental basis for forming its most active part – youth political leaders – has been revealed. The authors consider how the use of digital means of communication, social networks, and digital ecosystems contributes to the activation of youth participation in political life, accelerates the process of forming youth political leaders, providing their “promotion” in the online space and supporters mobilization. Challenges and threats of digitalization faced by youth and young political leaders have been considered. The authors concluded that digitalization at the present stage is the most important condition for attracting and forming youth political leadership, but this aspect requires further study and support at the public policy level.

Transformasi Era Digitalisasi Dalam Membentuk Jiwa Leadership Pada Gen-Z Dan Millenial

The purpose of this activity is to provide insight into relevant leadership skills, increase adaptability, and empower students to lead effectively in a dynamic work environment. The important target of the seminar Transforming the Digitalization Era in Shaping the Spirit of Leadership in Gen-Z and Millennials is all students of the Potensi Utama University, study program in preparing the younger generation to become adaptive, innovative, inclusive, and ethical leaders in the digital era. Through increased understanding of technology, development of leadership skills, formation of a collaborative spirit, expansion of professional networks, and ethical awareness, this seminar is expected to produce future leaders who are ready to face the complexities and opportunities offered by the modern world of work. The method was conducted indoors using slides and presentations in front of the students. Several questions and answers about the material provided were held to facilitate all students in understanding and knowing more about the material that had been delivered previously. The implementation of community service activities took place in the Hall Building B, University of Main Potential Medan starting at 09.00 WIB until completion, attended by 400 student participants from all study programs at the University of Main Potential both offline and online (zoom). Activities in the form of direct delivery of material. The results of the seminar activities are that students are expected to develop adaptive and innovative skills in accordance with the demands of the times, students will also be able to recognize and overcome the challenges of digitalization, as well as implement effective leadership strategies, In addition, this seminar aims to expand the professional network of participants, so that they can collaborate and share experiences with peers. Overall, the seminar is expected to produce young leaders who are ready to face the dynamics and complexities of the modern working world.

MYLead: Malaysian Young Leaders

MYLead: Malaysian Young Leaders

IES Moving Faster Than Ever—United, Collaborative, With Novel Entry Points for Young Leaders [Message From the President]

IES Moving Faster Than Ever—United, Collaborative, With Novel Entry Points for Young Leaders [Message From the President]

With ethics concerns rising again, NAATP seeks to guide young leaders

With ethics concerns rising again, NAATP seeks to guide young leaders

Introducing: Ulrich J. Lorenz, Radoslav I. Enchev, Clare F. Megarity, Helen Ginn, Patrick Rabe, Alice R. Walker, and Kartik Ayyer

In this Voices article we introduce seven impressive young group leaders who spoke at the recent Ringberg Workshop on Structural Biology organized by Ilme Schlichting from the Max Planck Institute for Medical Research, Heidelberg. We asked them to tell us more about their careers and their exciting research.

Evaluating the impact of digital technology on youth leadership development in the USA

Digital technology has become an integral part of modern society, influencing various aspects of daily life, including education and leadership development. This study aims to evaluate the impact of digital technology on youth leadership development in the USA. The research explores how digital technology, such as social media, online platforms, and digital communication tools, influences the development of leadership skills and qualities among young people. The study employs a mixed-methods approach, combining quantitative surveys and qualitative interviews to gather data from a diverse sample of youth leaders across the USA. Quantitative surveys are used to assess the extent to which digital technology is used in leadership development programs and its perceived impact on leadership skills. Qualitative interviews provide deeper insights into how digital technology influences the development of leadership qualities, such as communication, collaboration, and problem-solving skills. Preliminary findings suggest that digital technology plays a significant role in youth leadership development, offering new opportunities for learning and growth. Social media platforms, in particular, are identified as valuable tools for connecting with peers, sharing ideas, and mobilizing support for various causes. However, the study also highlights challenges associated with the use of digital technology, such as the risk of information overload and the potential for online harassment and bullying. The study concludes by emphasizing the need for educators, policymakers, and youth organizations to recognize the potential of digital technology in enhancing leadership development while addressing its challenges. Recommendations are provided for integrating digital technology into leadership development programs effectively, including the importance of digital literacy education and the need for policies that promote safe and responsible digital practices among young leaders. Overall, this study contributes to the growing body of literature on the impact of digital technology on youth development, providing valuable insights for practitioners and policymakers seeking to harness the power of digital technology for youth leadership development in the USA.

Navigating Leadership and Communication: A Study of Emerging Leaders in Indian Organizations

Introduction: The research explores the dynamic interplay between the leadership styles and communication strategies in Indian context. In order to understand the connection between leadership and communication this research will use SPSS. 
 Literature review: This section delves into unraveling the diverse spectrum of leadership styles that are prevalent in Indian organizations. The importance of the problem-solving and informational-sharing studies has emphasized the complexity of the evaluative steps that have guided the theoretical framework to enable the research methodology.
 Methodology: The primary quantitative methodology employs a survey tool which has been administered on the 55 participants. SPSS solution has recognised so many attributes that have benefitted the organizational outcomes. The application of correlation, descriptive analysis and ANOVA has accessorized the vital values by making qualitative and quantitative assessments yielding a broad perception.
 Findings: This section illuminates the prevalence of diverse leadership styles incorporating transformational leaderships. It adopts a clear and delicate model which places emphasis on women as key players to the economic emancipation of citizens. From the findings, it has been obtained that there is a significant relationship between employee commitment and organizational success which is -0.74 at 0.01 level of significance.
 Discussion: From the discussion section, it has been examined that for organizational practices and leadership developments, as a result of these actionable insights, the young leader in India has been able to initiate the social media revolution. Moreover, tailoring a clear and transparent organization has emerged as a common factor to acknowledge the quantitative approaches
 Conclusion: The conclusion restates the main findings, which would in turn conclude any contributions to food safety research which should be derived from the study. Moreover, the dynamics and organizations landscape has been considered to be increasingly successful in empowering the leaders by means of expertise irrespective of relevance. Such strategy works through the complex nature of Indian corporate and organizational paradigm principles, which provides the foundation for leadership development programs to be conducted in future among researchers broadly.
 

Social media usage and pyschosocial as contributing factor towards the formation of ideology: A preliminary study

Social media platforms have become the primary source of information, especially among young people. The reason is that the information shared on social media is quicker and more current. Exposure to social media information helps shape how they think and build their character and personality. Similarly, society, family, ideology, and media, grouped as psychosocial factors, influence ideological formation by contributing towards character building and strengthening worldview. However, excessive social media usage may negatively influence young people and the way they think, whereas psychosocial factors influence an individual's personality and thinking. Therefore, this study examines social media usage and psychosocial factors and their influence on young people's ideological formation. Using the quantitative methodology with a set of self-reporting questionnaires, about 128 respondents took part in the pilot study. It is found that ideological influence, social media influence, and socialization agents' influence positively correlate to ideological formation. These constructs positively impact and influence the formation of ideology, character-building, and rational thinking. Thus, the findings of this study are expected to help authorities apply positive values ​​from social media influence and psychosocial factors to the thinking process and ideological formation of young generation leaders today.

Sustainable Young Nursing Business Manager Leadership Competency: The Philippines Experience

The global shortage of qualified nurse managers, particularly evident in the Philippines, is rooted in the absence of training programs for transitioning nurses into management roles. Recent studies highlight this gap, leading to the promotion of inexperienced nurses to leadership positions and resulting in ineffective management practices and compromised care quality. Recognizing the importance of sustainable leadership competency for the long-term viability of healthcare services, a study in Metro Manila seeks to address these issues. The research focuses on gathering insights from nursing business experts regarding essential skills for sustainable leadership among young nursing business managers. The study aims to not only explore these perspectives but also assess the competency levels of young nurse managers using a newly developed survey tool. The objectives encompass determining expert views on necessary skills, profiling participants based on demographic factors, assessing competency levels, and drawing recommendations from the mixed-methods study results. Employing a mixed-method approach, the study initially conducted interviews with nursing business leaders in Manila. The themes derived from these interviews were then utilized in formulating the questionnaire. The findings revealed demographic variations among participants, influencing their responses. Five major themes emerged, reflecting participant perspectives on the competency of young nurse business managers: professional conduct, educational competency, individual assessment, trans-cultural competency, and informatics tech competency. In conclusion, the study emphasizes the diverse skills and competencies required by young nurse business leaders for effective functioning in occupational and professional settings. These competencies, spanning professional conduct, individual assessment, cultural competence, and technological proficiency, are deemed critical components in assessing and evaluating the effectiveness and efficiency of young nursing leaders, as emphasized in the existing literature. The study underscores the imperative for comprehensive training programs to enhance the competency of young nursing leaders, contributing to the overall quality and sustainability of healthcare services. Keywords: Nursing, leadership, Management, Concepts Investigated: professional conduct, individual assessment, culturally-inclined competency, informatics tech competency, educational competencies, Exploratory sequential Mixed-method , purposive sampling , The Philippines, South East Asia

Whom Should a Christian Vote? Facing Identity Politics from Biblical Perspective on Presidential Election

Indonesia stands firm in its democratic values and respects its presidential election in 2024. However, the scent of the history of identity politics still lingers and threatens the harmony of voting. Even though identity politics seem to be a common and acceptable method, it bears danger, especially to Christians as a minority. This can happen through the burdens and biases of Christians to vote. Through descriptive literature methods of biblical perspective with contextual interpretation alongside political reviews and literature, this paper tries to answer the question of how a Christian should vote for their future leader amidst the pressure of identity politics. The Bible can be a clear guideline to show that such political events and methods had already occurred in the Old Testament and New Testament eras. The wisdom contained in the Proverbs that was intended for future young leaders, as well as the wisdom of Jesus Christ, can help shape the answer on how a Christian should vote for their future leaders. This paper finds that Christians as minorities should try to be objective following biblical standards and the quality of a leader, such as righteousness, multiple councils, servanthood, and accountability, rather than drowning in misconceptions of defensive and subjective votes based on religion-ethnicity sameness or popular opinion.