Young Urbanites Research Articles

Return to the countryside: An ethnographic study of young urbanites in Japan's shrinking regions

This article studies urban–rural mobilities in contemporary Japan using several island communities in the Setouchi region of the Seto Inland Sea as a case study. It seeks to examine the phenomenon of den-en kaiki (rural return) with a focus on young Japanese urbanites moving to depopulated regions outside large cities. Based on a 15-month ethnographic study, the paper draws on original in-depth qualitative interviews with 35 individuals in their 20s–40s. The findings show that while some may be more traditional “lifestyle migrants,” many are adopting rural living as a temporary escape from the city and are not necessarily committed to staying long term. The narratives reveal diverse mobilities as a reflection of the changing attitudes of young Japanese attempting to find meaning and satisfaction while sustaining a livelihood in post-growth Japan. The growing importance of the “relationship population,” referring to urbanites who spend extended time in rural communities but do not live there, is discussed to broaden existing conceptions of rural mobilities from the Japanese context. The messiness of rural mobilities in contemporary Japan highlights the need for an expanded understanding of concepts such as counter-urbanization to include various forms of exchange and consider how they can contribute to the future sustainability of rural spaces.

Decolonizing the pocket monster: Smartphones, Pokémon Go and generational conflict in Malaysian Borneo

This article analyzes the generational politics of smartphones in the Malaysian state of Sarawak in the context of Bornean history and contemporary Sarawakian political economy. We respond to a global north bias in the standing literature on smartphone media and suggest approaches to improve representation of global south perspectives. Concretely, we propose three programmatic maxims as a methodological guide to incorporate perspectives and concerns from the global south more fully. Drawing on long-term ethnographic research in Sarawak, we demonstrate the value of these suggestions by framing smartphones in the perspective of Bornean history as tools for maintaining instrumental social networks more than exchanging information across spatial disjunction. These tools are used differently by young urbanites and older rural populations. This leads us to show how Pokémon Go refracts generational conflicts by becoming the cultural touchstone of the changing political economic conditions of Malaysian urbanization.

The institutionalization of shared rental housing and commercial co-living

In context of diminishing housing affordability, shared renting has acquired new salience in recent years, especially for single young-adults. Public discourses often pose shared renting as a potential solution to the ‘housing crisis’, with new regulation and investment stimulating conversions to multiple-occupancy and growth in co-living developments. This paper addresses how Amsterdam, a deeply regulated market, has approached affordability concerns through transformations in the shared rental sector. Drawing on secondary data and stakeholder interviews we analyze developments in the institutional features of shared housing, focusing on the regulatory context under neo-liberal pressures. We identify shifts from ‘traditional’, relatively informalized sharing arrangements towards a more complex and institutionalized sector featuring growth and diversification in co-living provision. Beyond illustrating interaction between changing real-estate investment practices and Amsterdam’s socioeconomic and regulatory context, our analysis innovates a rough typology of sharing and co-living and seeks to contribute to understanding of emerging forms of housing and precarity characteristic to the experiences of young urbanites.

Fall Risk, Sleep Behavior, and Sleep-Related Movement Disorders in Young Urbanites Exposed to Air Pollution.

Quadruple aberrant hyperphosphorylated tau, amyloid-β, α-synuclein, and TDP-43 pathology had been documented in 202/203 forensic autopsies in Metropolitan Mexico City ≤40-year-olds with high exposures to ultrafine particulate matter and engineered nanoparticles. Cognition deficits, gait, equilibrium abnormalities, and MRI frontal, temporal, caudate, and cerebellar atrophy are documented in young adults. This study aimed to identify an association between falls, probable Rapid Eye Movement Sleep Behavior Disorder (pRBD), restless leg syndrome (RLS), and insomnia in 2,466 Mexican, college-educated volunteers (32.5±12.4 years). The anonymous, online study applied the pRBD and RLS Single-Questions and self-reported night-time sleep duration, excessive daytime sleepiness, insomnia, and falls. Fall risk was strongly associated with pRBD and RLS. Subjects who fell at least once in the last year have an OR = 1.8137 [1.5352, 2.1426] of answering yes to pRBD and/or RLS questions, documented in 29% and 24% of volunteers, respectively. Subjects fell mostly outdoors (12:01 pm to 6:00 pm), 43% complained of early wake up hours, and 35% complained of sleep onset insomnia (EOI). EOI individuals have an OR of 2.5971 [2.1408, 3.1506] of answering yes to the RLS question. There is a robust association between falls, pRBD, and RLS, strongly suggesting misfolded proteinopathies involving critical brainstem arousal and motor hubs might play a crucial role. Nanoparticles are likely a significant risk for falls, sleep disorders, insomnia, and neurodegenerative lethal diseases, thus characterizing air particulate pollutants' chemical composition, emission sources, and cumulative exposure concentrations are strongly recommended.

FATTY ACID PROFILE OF FAST FOODS, TRADITIONAL SNACKS AND SWEETMEATS OF BANGLADESH

A total of 184 samples from 18 varieties of commercial fast foods, traditional snacks and sweetmeats of Dhaka city were examined for fatty acid composition, percentage of monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), and saturated fatty acid (SFA). Fatty acid methyl esters prepared from lipid extracts were analyzed by gas-liquid chromatography using capillary columns. The percentage of total fatty acid of these foods was determined. In general, traditional snacks showed high proportion of SFA (ranged 24.4-65.5%) and fast foods showed high proportion of PUFA (ranged 11.9-52.8%). The MUFA content, on the other hand, in all foods ranged 29.8-42.3% with a predominant contribution by oleic acid (18:1). The findings of the study showed that these Bangladeshi commercial fast foods and traditional snacks were high in SFA especially in chicken patties (50.2%), beef pizza (48.1%), beef patties (46.6%), and all sweetmeats (ranged 52.8-65.5%) except kalojam (35.6%). The source of SFA in the fat fraction was basically animal fats and palm oil. The experimental results showed that the Bangladeshi young urbanites who are accustomed to fast foods culture seem to be in the risk of high energy intake with an excessive share of SFA.

TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM2.5 and Ultrafine Particles and Historically Showing Alzheimer and Parkinson's Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations.

Environmental exposures to fine particulate matter (PM2.5) and ultrafine particle matter (UFPM) are associated with overlapping Alzheimer’s, Parkinson’s and TAR DNA-binding protein 43 (TDP-43) hallmark protein pathologies in young Metropolitan Mexico City (MMC) urbanites. We measured CSF concentrations of TDP-43 in 194 urban residents, including 92 MMC children aged 10.2 ± 4.7 y exposed to PM2.5 levels above the USEPA annual standard and to high UFPM and 26 low pollution controls (11.5 ± 4.4 y); 43 MMC adults (42.3 ± 15.9 y) and 14 low pollution adult controls (33.1 ± 12.0 y); and 19 amyotrophic lateral sclerosis (ALS) patients (52.4 ± 14.1 y). TDP-43 neuropathology and cisternal CSF data from 20 subjects—15 MMC (41.1 ± 18.9 y) and 5 low pollution controls (46 ± 16.01 y)—were included. CSF TDP-43 exponentially increased with age (p < 0.0001) and it was higher for MMC residents. TDP-43 cisternal CSF levels of 572 ± 208 pg/mL in 6/15 MMC autopsy cases forecasted TDP-43 in the olfactory bulb, medulla and pons, reticular formation and motor nuclei neurons. A 16 y old with TDP-43 cisternal levels of 1030 pg/mL exhibited TDP-43 pathology and all 15 MMC autopsy cases exhibited AD and PD hallmarks. Overlapping TDP-43, AD and PD pathologies start in childhood in urbanites with high exposures to PM2.5 and UFPM. Early, sustained exposures to PM air pollution represent a high risk for developing brains and MMC UFPM emissions sources ought to be clearly identified, regulated, monitored and controlled. Prevention of deadly neurologic diseases associated with air pollution ought to be a public health priority and preventive medicine is key.

#peacemaker: Cultivating Pluralist Dispositions among Bandung’s Peace Communities Online and Offline

Abstract In Indonesia, the national motto of ‘unity in diversity’ is challenged, not least by a hardening of religious identities, coupled with rising levels of religious intolerance. In addition to established proponents of religious pluralism, groups of activists strive to sow the seeds of peace among the tech-savvy generation of young urbanites. By adopting the concept of ‘technology of the community’, I analyze the online and offline practices of peace activists in Bandung in 2018 to educate young #peacemakers and create spaces of empathy and solidarity. To address the emotional deprivation as well as aspirations of young people, peace groups rely on various offline and online technologies that straddle notions of comfort and discomfort, of tolerance and engagement. In creating and maintaining spaces of affective interpersonal exchange, these groups become exponents of local arrangements that are conducive to the cultivation of pluralist dispositions beyond national ideology.

“The Stinkier the Better!”—A Case Study on the Reinvention of River Snail Noodles and the Transformation of Taste in China

ABSTRACT This article uses luosifen – river snail rice noodles that originated in Liuzhou, China – as a lens to explore the relationship between food production and the breakthrough processes that prompt young urbanites in contemporary China to acquire new and exotic tastes. Although snail noodles, famous for their stinky smell, have recently gained recognition as a national intangible cultural heritage, the consumption of snail noodles in China today is actually a reinvented tradition developed from those of the Zhuang and Han ethnic groups. The current popularity of snail noodles results from neoliberal consumerism, advancements in food packaging and technology, and new ways for consumers to engage each other in social relationships created by social media, all in the context of rapid social change and urbanization. The Liuzhou local government’s strategy of transforming snail noodles from modern street food into exotic culinary heritage has opened up new forms of cultural and social capital.

Japanese rural resettlers: communities with newcomers as heterotopic spaces

The increasing number of young urbanites settling into the countryside of Japan compels urgent research on communities with newcomers and newly emerging lifestyles. This article explores the daily practices of newcomers to rural areas to understand the complexity of the transformation of rurality in contemporary post-growth Japan. This study was conducted in 2011–2015 and draws upon ethnographic data from rural communities. The article details three distinctive lifestyles practiced by rural newcomers: self-sufficiency in food, agro-entrepreneurship, and an “average” way of life. This article analyzes contemporary rural Japan through the lens of heterotopia as a specific characteristic of modern space where seemingly incompatible sites are set side by side. Highlighting the complexity of contemporary rural spaces allows for challenging the norms of conventional perceptions of rurality.

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders.

Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale–Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.

Environmental Fe, Ti, Al, Cu, Hg, Bi, and Si Nanoparticles in the Atrioventricular Conduction Axis and the Associated Ultrastructural Damage in Young Urbanites: Cardiac Arrhythmias Caused by Anthropogenic, Industrial, E-Waste, and Indoor Nanoparticles.

Air pollution exposure is a risk factor for arrhythmia. The atrioventricular (AV) conduction axis is key for the passage of electrical signals to ventricles. We investigated whether environmental nanoparticles (NPs) reach the AV axis and whether they are associated with ultrastructural cell damage. Here, we demonstrate the detection of the shape, size, and composition of NPs by transmission electron microscopy (TEM) and energy-dispersive X-ray spectrometry (EDX) in 10 subjects from Metropolitan Mexico City (MMC) with a mean age of 25.3 ± 5.9 and a 71-year-old subject without cardiac pathology. We found that in every case, Fe, Ti, Al, Hg, Cu, Bi, and/or Si spherical or acicular NPs with a mean size of 36 ± 17 nm were present in the AV axis in situ, freely and as conglomerates, within the mitochondria, sarcomeres, lysosomes, lipofuscin, and/or intercalated disks and gap junctions of Purkinje and transitional cells, telocytes, macrophages, endothelium, and adjacent atrial and ventricular fibers. Erythrocytes were found to transfer NPs to the endothelium. Purkinje fibers with increased lysosomal activity and totally disordered myofilaments and fragmented Z-disks exhibited NP conglomerates in association with gap junctions and intercalated disks. AV conduction axis pathology caused by environmental NPs is a plausible and modifiable risk factor for understanding common arrhythmias and reentrant tachycardia. Anthropogenic, industrial, e-waste, and indoor NPs reach pacemaker regions, thereby increasing potential mechanisms that disrupt the electrical impulse pathways of the heart. The cardiotoxic, oxidative, and abnormal electric performance effects of NPs in pacemaker locations warrant extensive research. Cardiac arrhythmias associated with nanoparticle effects could be preventable.

Climate change concern and the desire to travel: How do I justify my flights?

There is an urgent need to reduce emissions from the aviation sector. Although awareness of climate change is growing, few are willing to alter their flight behaviour. Through a qualitative analysis of interview materials collected from Reykjavik Capital Region residents, this study explores how globally affluent, highly mobile young urbanites justify their international travel by plane, despite their climate change awareness, and if they are willing to change their behaviour. Six themes of justifications to continue air travel were identified; shifting responsibility, compensatory behaviours, lack of knowledge or awareness, lack of other options, benefits outweighing impacts, and carbon offsetting. Their use differed depending on respondents’ level of climate change awareness and willingness to reduce air travel, but willingness to reduce travel did not differ between awareness level scores. None were willing to quit flying regardless of their level of awareness. Compared with previous literature, we found a greater emphasis placed on the benefits of air travel. We suggest policy uptake for both individual and collective realms, such as kerosene tax and mandatory carbon offsetting, as shifting responsibility can delay action regardless of the way in which it is shifted, and reductions in these realms can only happen in concert. Other sources of well-being should be emphasized and the social norm around frequent travel actively challenged. Knowledge on the specific climate impacts of flights should be better communicated to the public and put into perspective with the global fair share of emissions and steep mitigation curves to keep warming below 1.5°.

Yawn: Boredom and Powerlessness in the Late Ottoman Empire

Abstract Over the last decade or so, boredom has attracted tremendous media and scholarly attention. Historians, however, remained largely uninterested, which is all the more surprising considering the wide consensus among scholars about the historicity of modern boredom, and its distinctiveness from earlier forms of tedium. This article joins a handful of works that discussed boredom in concrete historical contexts, focusing on the late Ottoman Empire. The article places boredom in two different discourses, developed by different generations of writers. The first was promoted by the Hamidian regime (1876–1908) and some of the most prominent writers of the time. In this discourse, the boredom of subalterns, including soldiers, women, and youngsters was considered a social problem. Hegemonic writers blamed boredom on the bored, warned that it could breed “harmful” ideas and behaviors, and spurred their addressees to become productive subjects promoting their own personal, and imperial, progress. But for young and educated urbanites, probably the foremost target group of this discourse, the motivational talk was itself dull. Pinned down by their elders, by their social superiors, by an oppressive political system that offered little true prospect of “advancement,” all these youngsters could do was to disengage and wait. Their own discourse therefore associated boredom not with indolence but with estrangement, melancholy, and frustration. So while hegemonic writers interpreted these emotions in terms of lethargy and decadence, they in fact held potential political energy, which later fed the uprising against the Hamidian order in the summer 1908.

The bicycle as a symbol of lifestyle, status and distinction. A cultural studies analysis of urban cycling (sub)cultures in Berlin

ABSTRACT The bicycle has been gaining attention in planning, politics, academia and across the media and has become increasingly present in urban landscapes and popular cultures: young urbanites ride minimalistic, stylish and individualised bicycles and wear messenger bags for their commute to work or to university. Additionally, bicycles can be seen in lifestyle blogs, advertising, shop windows or living rooms as decoration and eye-catchers. Taking this observation as a starting point, I focus my research on how bicycles, especially fixed-gear bikes and recent cycling trends are being used to express lifestyle, status, and social distinction in an urban middleclass context. In order to investigate further, I conducted a cultural studies analysis based on participant observations and media analysis exploring cultural meanings and practices in urban cycling cultures in Berlin, Germany. My research leads me to the result that the bicycle is increasingly turning into a key object of popular urban culture, combining tendencies of commercialisation, specialisation and standardisation, with a strong focus on aesthetics, design, lifestyle and consumerism. In the context of urban cultures, the bicycle is therefore experiencing a symbolic revaluation, making it desirable to more and more urbanites, but also more exclusive.

Interface culture and gendered privacy risks in the context of Chinese locative social media use

ABSTRACT Across the world, young people are increasingly using locative social media applications to socialize with strangers for dating opportunities. This phenomenon is also found in Chinese society, where such applications are very popular with young Chinese urbanites. This article presents a case study of how young Chinese urbanites navigate social interactions with strangers on WeChat People Nearby, based on the findings of interviews with 19 Chinese university students aged between 18 and 23. By drawing on the notion of interface, we uncover how gender dynamics are established in young Chinese urbanites’ People Nearby use and how the gender dynamics are engineered by the privacy paradox of interfaced social interactions between strangers in the locality. The outcomes of the present research help us to understand the gender-related opportunity-risk axis established in young Chinese urbanites’ everyday use of locative social media applications.

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

To determine whether gait and balance dysfunction are present in young urbanites exposed to fine particular matter PM2.5 ≥ annual USEPA standard, we tested gait and balance with Tinetti and Berg tests in 575 clinically healthy subjects, age 21.0 ± 5.7 y who were residents in Metropolitan Mexico City, Villahermosa and Reynosa. The Montreal Cognitive Assessment was also applied to an independent cohort n:76, age 23.3 ± 9.1 y. In the 575 cohort, 75.4% and 34.4% had abnormal total Tinetti and Berg scores and high risk of falls in 17.2% and 5.7% respectively. BMI impacted negatively Tinetti and Berg performance. Gait dysfunction worsen with age and males performed worse than females. Gait and balance dysfunction were associated with mild cognitive impairment MCI (19.73%) and dementia (55.26%) in 57/76 and 19 cognitively intact subjects had gait and balance dysfunction. Seventy-five percent of urbanites exposed to PM2.5 had gait and balance dysfunction. For MMC residents-with historical documented Alzheimer disease (AD) and CSF abnormalities, these findings suggest Alzheimer Continuum is in progress. Early development of a Motoric Cognitive Risk Syndrome ought to be considered in city dwellers with normal cognition and gait dysfunction. The AD research frame in PM2.5 exposed young urbanites should include gait and balance measurements. Multicity teens and young adult cohorts are warranted for quantitative gait and balance measurements and neuropsychological and brain imaging studies in high vs low PM2.5 exposures. Early identification of gait and balance impairment in young air pollution-exposed urbanites would facilitate multidisciplinary prevention efforts for modifying the course of AD.

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal

Fine particulate air pollution (PM2.5) exposures are linked with Alzheimer's and Parkinson's diseases (AD,PD). AD and PD neuropathological hallmarks are documented in children and young adults exposed lifelong to Metropolitan Mexico City air pollution; together with high frontal metal concentrations (especially iron)–rich nanoparticles (NP), matching air pollution combustion- and friction-derived particles. Here, we identify aberrant hyperphosphorylated tau, ɑ synuclein and TDP-43 in the brainstem of 186 Mexico City 27.29 ± 11.8y old residents. Critically, substantia nigrae (SN) pathology seen in mitochondria, endoplasmic reticulum and neuromelanin (NM) is co-associated with the abundant presence of exogenous, Fe-, Al- and Ti-rich NPs.The SN exhibits early and progressive neurovascular unit damage and mitochondria and NM are associated with metal-rich NPs including exogenous engineered Ti-rich nanorods, also identified in neuroenteric neurons. Such reactive, cytotoxic and magnetic NPs may act as catalysts for reactive oxygen species formation, altered cell signaling, and protein misfolding, aggregation and fibril formation. Hence, pervasive, airborne and environmental, metal-rich and magnetic nanoparticles may be a common denominator for quadruple misfolded protein neurodegenerative pathologies affecting urbanites from earliest childhood. The substantia nigrae is a very early target and the gastrointestinal tract (and the neuroenteric system) key brainstem portals. The ultimate neural damage and neuropathology (Alzheimer's, Parkinson's and TDP-43 pathology included) could depend on NP characteristics and the differential access and targets achieved via their portals of entry. Thus where you live, what air pollutants you are exposed to, what you are inhaling and swallowing from the air you breathe,what you eat, how you travel, and your occupational longlife history are key. Control of NP sources becomes critical.

Autonomous vehicles lite self-driving technologies should start small, go slow

Many young urbanites don't want to own a car, and unlike earlier generations, they don't have to rely on mass transit. Instead they treat mobility as a service: When they need to travel significant distances, say, more than 5 miles (8 kilometers), they use their phones to summon an Uber (or a car from a similar ride-sharing company). If they have less than a mile or so to go, they either walk or use various “micromobility” services, such as the increasingly ubiquitous Lime and Bird scooters or, in some cities, bike sharing. The problem is that today's mobility-as-a-service ecosystem often doesn't do a good job covering intermediate distances, say a few miles. Hiring an Uber or Lyft for such short trips proves frustratingly expensive, and riding a scooter or bike more than a mile or so can be taxing to many people. So getting yourself to a destination that is from 1 to 5 miles away can be a challenge. Yet such trips account for about half of the total passenger miles traveled. Many of these intermediate-distance trips take place in environments with limited traffic, such as university campuses and industrial parks, where it is now both economically reasonable and technologically possible to deploy small, low-speed autonomous vehicles powered by electricity. We've been involved with a startup that intends to make this form of transportation popular. The company, PerceptIn, has autonomous vehicles operating at tourist sites in Nara and Fukuoka, Japan; at an industrial park in Shenzhen, China; and is just now arranging for its vehicles to shuttle people around Fishers, Ind., the location of the company's headquarters.

The Social Deviance of the Vietnamese Young toward Values and Lifestyles, Gender, Communication, and Family Customs

This study report is an analysis result of a quantitative survey on attitudes of Vietnamese youth both male (M) and female (F) who are civil servants, workers, young urbanites, rural youth, Pupil, Student, the young violated the laws about living styles, gender, communication, and family. The findings show that young people have opposite tendencies. Some of them advocate things have been traditionally named, while others are looking for and living in new ways which are being labelled as a kind of social deviance.

Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution

Exposure to air pollutants is associated with an increased risk of developing Alzheimer's disease (AD). AD pathological hallmarks and cognitive deficits are documented in children and young adults in polluted cities (e.g. Metropolitan Mexico City, MMC). Iron-rich combustion- and friction-derived nanoparticles (CFDNPs) that are abundantly present in airborne particulate matter pollution have been detected in abundance in the brains of young urbanites. Epigenetic gene regulation has emerged as a candidate mechanism linking exposure to air pollution and brain diseases. A global decrease of the repressive histone post-translational modifications (HPTMs) H3K9me2 and H3K9me3 (H3K9me2/me3) has been described both in AD patients and animal models. Here, we evaluated nuclear levels of H3K9me2/me3 and the DNA double-strand-break marker γ-H2AX by immunostaining in post-mortem prefrontal white matter samples from 23 young adults (age 29 ± 6 years) who resided in MMC (n = 13) versus low-pollution areas (n = 10). Lower H3K9me2/me3 and higher γ-H2A.X staining were present in MMC urbanites, who also displayed the presence of hyperphosphorylated tau and amyloid-β (Aβ) plaques. Transmission electron microscopy revealed abundant CFDNPs in neuronal, glial and endothelial nuclei in MMC residents' frontal samples. In addition, mice exposed to particulate air pollution (for 7 months) in urban Santiago (Chile) displayed similar brain impacts; reduced H3K9me2/me3 and increased γ-H2A.X staining, together with increased levels of AD-related tau phosphorylation. Together, these findings suggest that particulate air pollution, including metal-rich CFDNPs, impairs brain chromatin silencing and reduces DNA integrity, increasing the risk of developing AD in young individuals exposed to high levels of particulate air pollution.