ABSTRACTThe Crop Water Stress Index (CWSI) is a widely used method for quantifying crop water status and predicting yield. However, its evaluation across different irrigation methods and its stage‐specific response to crop yield is rarely evaluated. In this study, controlled field experiments were conducted on winter wheat using drip irrigation (DI) and flood irrigation (FI) during the 2021–2022 and 2022–2023 seasons in western Uttar Pradesh, India. The irrigation treatments included 50% MAD (maximum allowable depletion) (DI), 55% MAD (DI), 60% MAD (DI), 50% MAD (FI), local farmer's field replication (FI), rain‐fed, and well‐watered treatment (DI). The derived mean CWSI values for the irrigation treatments ranged from 0.03 to 0.66 in season 1 and 0.06 to 0.57 in season 2 across treatments. The seasonal mean CWSI for 50% MAD (DI) was 0.12 (season 1) and 0.11 (season 2), while 50% MAD (FI) yielded higher mean CWSI values of 0.29 (season 1) and 0.22 (season 2). The 50% MAD (DI) treatment produced the highest grain yield and water use efficiency in both seasons. A comprehensive analysis of stage‐specific CWSI values and grain yields revealed that grain yield was more sensitive to post‐heading CWSI as compared to pre‐heading CWSI values. Among the growth stages, CWSI values during the flowering stage were the most critical for predicting wheat yield. The study recommends that the CWSI values in the flowering and post‐heading stages are more relevant in predicting wheat yield accurately as compared to the pre‐heading and seasonal mean CWSI.