Xinjiang Uygur Autonomous Region People Research Articles

Effect of admission mode of septic patients in intensive care unit on acute kidney injury and prognosis

To investigate the effect of intensive care unit (ICU) admission model on acute kidney injury (AKI) development and the prognosis in patients with sepsis. Patients with sepsis admitted to the ICU of Xinjiang Uygur Autonomous Region People's Hospital from January 2019 to July 2020 were retrospectively analyzed. According to the ICU admission model, the patients were divided into emergency group (first admission or emergency transfer from relevant surgical departments) and delayed group (transferred from the general ward due to disease evolution). Patients were divided into AKI group and non-AKI group according to whether AKI was accompanied. The gender, age, underlying diseases, surgical history, heart rate, laboratory test indicators, acute physiology and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), organ failure and acute complications were collected. The incidence of AKI, 28-day mortality and length of ICU stay were recorded. Univariate and multivariate Logistic regression was used to analyze the risk factors of AKI in patients with sepsis. A total of 185 patients with sepsis were enrolled, including 96 cases in the emergency group and 89 cases in the delayed group. 119 cases of AKI occurred while 66 cases without AKI development. The incidence of AKI within 7 days and the 28-day mortality of patients in the delayed group were significantly higher than those in the emergency group [AKI incidence rate: 77.53% (69/89) vs. 52.08% (50/96), 28-day mortality: 24.72% (22/89) vs. 10.42% (10/96), both P < 0.05], and the length of ICU stay was significantly longer than that of the emergency group (days: 18.70±7.29 vs. 14.56±4.75, P < 0.05). Univariate Logistic analysis showed that there were significant differences in age, diabetes, hypertension, organ failure, heart failure, APACHE II score, SOFA score, white blood cell count (WBC), absolute neutrophil value, platelet count (PLT), blood lactate, total bilirubin, and ICU transferred from general wards between AKI group and non-AKI group. Multivariate Logistic regression analysis showed that transfer from general ward to ICU due to disease evolution was an independent risk factor for AKI in ICU sepsis patients [odds ratio (OR) = 5.165, 95% confidence interval (95%CI) was 3.911-6.823, P < 0.001]. Septic patients transferred from general ward to ICU due to disease evolution are more likely to develop AKI, and also had a higher mortality and longer ICU stay. It may be an independent risk factor for AKI complicated by patients with sepsis in ICU.

Role of MDA in the pathogenesis of GERD esophagus mucosal inflammatory injury

Objective To investigate the expression of malondialdehyde (MDA) in esophageal mucosa of different types of gastroesophageal reflux disease (GERD) patients and its role in the esophageal inflammation. Methods According to the inclusion and exclusion criteria, 42 patients hospitalized in the the Xinjiang Uygur Autonomous Region People′s Hospital from December 2017 to October 2018 were selected as the research group. 8 healthy subjects completed physical examination were set up as healthy control group. GERD completed GERDQ score, 24 h pH monitoring, and taken 3 cm on the dentate line of the esophagus as a specimen. The study group was divided into non-erosive reflux disease (NERD) group (17 cases) and Erosive reflux disease [erosive esophagitis (RE)] group (25 cases). Then hematoxylin-eosin (HE) staining, immunohistochemistry, real-time polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA) methods were used to detect inflammation, oxidative stress (MDA), antioxidant enzyme [manganese superoxide dismutase (Mn SOD), glutathione (GSH), catalase (CAT)], and proinflammatory cytokines [monocyte chemotactic protein-1 (MCP-1), interlukin-8 (IL-8), tumor necrosis factor α (TNF- α)]. Results There was no significant difference in body mass index (BMI) between the three groups (P>0.05). 24 h pH monitoring of esophagus showed that the indexes of weak acid reflux (4 0.05). In RE group , the infiltration of immune cells (neutrophils, eosinophils), nipple lengthening, edema and other inflammatory changes were found in the esophageal mucosa, and the inflammation score reached the peak, which was significantly higher than that in NERD group, with statistical significant difference (P<0.001). The positive expression of MDA in the two groups (NERD, RE) was higher than that in the control group, and the MDA expression in the RE group was almost covered with the full layer esophagus.The serum MDA concentration in the NERD and RE groups was significantly higher than that in the control group (P<0.001). Compared with the NERD group, the serum MDA in the RE group reached the peak (P<0.01). The relative expression of mRNA (Mn SOD, GSH and CAT) in NERD group and RE group was significantly decreased, and there was a significant difference between the three groups (P<0.001). Compared with the NERD group, the mRNA expression level of Mn SOD and CAT in RE group was significantly decreased (P<0.01). The relative expression of mRNA (MCP-1, IL-8, TNF- α) increased significantly in the two groups (NERD, RE), and there was a statistically significant difference between the three groups (P<0.001). Compared with the NERD group, the expression of its inflammatory factors in the RE group significantly increased (P<0.01). Conclusions The expression level of MDA in different types of GERD is significantly higher, which may be closely related to esophageal inflammation induced by acid reflux. Key words: Malondialdehyde; Gastroesophageal reflux; Esophageal mucosa; Inflammation; Oxidative stress

DECREASED NOCTURNAL MEAN OXYGEN SATURATION WAS ASSOCIATED WITH HYPERHOMOCYSTEINEMIA

Objective: To observe the relationship between plasma Homocysteine (Hcy) level and nocturnal sleep parameters in patients with hypertension. Design and method: A total of 1,663 patients admitted to the department of hypertension of xinjiang uygur autonomous region people's hospital from 2005 to 2010 were selected as observation objects, observation objects was divided into three groups according to the tri-sectional quantiles of plasma Hcy level.(Group A:Hcy<=10.74umol/L, Group B:10.74umol/L<Hcy<=16.24umol/L, Group C:Hcy>16.24umol/L). All subjects underwent polysomnography (PSG) to analyze and compare the general characteristics and nighttime sleep parameters (AHI, AI, SaO2 min, SaO2 mean, N1, N2, N3, N4, REM, ODI3, ODI4, TS90%) of patients in different groups. Multivariate Logistic regression was used to analyze the relationship between nocturnal sleep parameters and plasma Hcy. Results: Plasma Hcy increased gradually in patients with non, mild, moderate and severe OSA(12.23umol/L,12.6umol/L,13.14umol/L,13.66umol/L, P = 0.023). The differences of AHI, SaO2 min (%), SaO2 mean (%), N3 (%), shallow sleep stage (%), deep sleep stage (%), OD3 (times /h), OD4 (times /h), and ts90% were statistically significant in the three groups. Multiple Logistic regression analysis showed that after adjusting for gender, age, smoking and drinking history, the risk of hyperhomocysteinemia increased gradually with the decrease of mean blood oxygen saturation(OR1 = 1.039, P1 = 0.813. OR2 = 1.418, P2 = 0.011) Conclusions: With the aggravation of OSA, the plasma Hcy level increases in the patients with hypertension. The lower the average blood oxygen saturation at night, the higher the risk of hyperhomocysteinemia..

“Our Common Home – Altai”: international ecological-economical and humanitarian integration in the Altai region

Cooperation of the border regions of the four countries, whose territories are located in the Altai mountain system, the so-called “The Great Altai”, contributed to the establishment of the International Coordination Council “Our Common Home – Altai” (ICC “Altai”) in 2003. The ICC “Altai” includes representatives of the legislative (representative) and executive powers of the Altai region and the Republic of Altai (Russian Federation), East Kazakhstan Region (The Republic of Kazakhstan), Xinjiang Uygur Autonomous Region (People’s Republic of China), and Khovd, Bayan-Ulgii aimags (Mongolia). The main objectives of the ICC “Altai” are the development and strengthening of trust, mutual understanding and good neighborliness among representatives of states, cultures and nationalities in the strategically significant Eurasian region of the Great Altai, as well as ensuring sustainable social and economic development of the border areas. In the conditions of geopolitical splits and geoeconomic rivalries that have become more complicated and openly manifested in international relations, the processes of consolidation of border regions and actions to create cross-border economic actors are updated in a new way. The need for joint measures and steps to stimulate the competitiveness of local economies in the territories of the Great Altai makes it necessary to develop common governance and coordination structures.

Analysis of risk factors between young and middle-aged patients and old-aged patients with hypertensive cerebral hemorrhage in the Kazakhs of xinjiang

Objective To analyze the risk factors between young and middle-aged patients and old-aged patients with hypertensive cerebral hemorrhage in the Kazakhs of Xinjiang. Methods A retrospective analysis of the 127 cases with hypertensive cerebral hemorrhage in the Xinjiang Uygur Autonomous Region people's Hospital. In addition, 171 patients with non cerebral hemorrhage were selected as the control group. All the patients were divided into young and middle-aged group and old-aged group. The risk factors of two groups of hypertensive intracerebral hemorrhage were compared, and two groups of risk factors were analyzed by Logistic regression analysis. Results There were significant differences in diabetes, coronary heart disease, alcohol drinking, disease awareness, treatment compliance, systolic pressure, diastolic pressure, low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum homocysteine (Hcy) and carotid atherosclerosis between the two groups (P<0.05). Logistic regression analysis showed that the independent risk factors of young and middle-aged patients with hypertensive cerebral hemorrhage in the Kazakhs of Xinjiang included alcohol drinking, treatment compliance, systolic pressure, diastolic pressure and Hcy (P<0.05), but systolic pressure, Hcy and carotid atherosclerosis were the independent risk factors of old-aged patients (P<0.05). Conclusions There were differences in the risk factors between young and middle-aged patients and old-aged patients with hypertensive cerebral hemorrhage in the Kazakhs of xinjiang, but systolic pressure and Hcy were both the independent risk factors of the two groups. Key words: Intracranial hemorrhage, hypertensive; Risk factors; Factor analysis, statistical

Clinical and laboratory characteristics of 11 cases of chronic B lymphocyte proliferation disease without lymphoid proliferation

Objective To explore the clinical and laboratory characteristics of chronic B lymphocyte proliferation disease (B-CLPD) without typical lymphoid proliferation. Methods The clinical records of patients with B-CLPD only characterized by pancytopenia form January 2007 to March 2016 in hematology department of Xinjiang Uygur Autonomous Region People's Hospital were collected, and the cell morphology, bone marrow pathology, cytogenetics and molecular characteristics were retrospectively analyzed. Results The median age of 11 patients was 68 years old. The lymphocyte ratio of peripheral blood smears in all patients increased in different level (0.36-0.68), but absolute lymphocyte count was normal or decreased (0.59×109-1.99×109). Lymphocyte-like plasma cell or small numbers of plasma cell can be seen in the bone marrow smears of 4 cases and lymphocytes with irregular burr-like protrusions were observed in 2 cases while there were no characteristic morphological changes in remained 5 cases. Immunophenotypical analysis showed that all patients expressed CD19, CD20, CD22, SmIg, not expressed CD5, CD10 which with scores of 0-2 according to chronic lymphocytic leukemia (CLL) points system; CD103, CD11C, CD25 and FMC7 were highly expressed in 2 cases while there were no characteristic expression in remaining cases. There were no abnormal karyotypes observed from the conventional cytogenetic and fluorescence in situ hybridization (FISH) analysis (both of IgH/CCND1, bcl-2/IgH were negative) in all patients. 8 patients were found IgH gene rearrangement, MYD88L256P and BRAF V600E was positive in 5 cases and 2 cases respectively. 5 cases were diagnosed as Waldenstrom macroglobulinemia, 3 cases were B-CLPD, 2 cases were hairy cell leukemia, 1 case was nodal marginal zone B-cell lymphoma after comprehensive analysis of their clinical and laboratory data. Conclusion Even if there are no increased peripheral blood lymphocytes in pancytopenia patients, it is necessary to perform bone marrow smears, immunophenotyping, IgH gene rearrangement, cytogenetics and other molecular laboratory tests to exclude B-CLPD, and reduce misdiagnosis. Key words: Chronic B lymphocyte proliferation disease; Diagnosis; Cell morphology; Immunologic techniques; Cytogenetics; Molecular biology

Efficacy of 3D print guide technique in one stage posterior approach for the treatment of cervical and thoracic tuberculosis with kyphosis

Objective: To investigate the application of 3D printing technology in the treatment of patients with cervical kyphosis and paraplegia in different segments of the cervical spine after one-stage debridement, bone graft fusion and pedicle screw fixation. Methods: From January 2008 to January 2017, a total of 31 patients with thoracolumbar tuberculosis were treated in the Department of Orthopaedics, the Xinjiang Uygur Autonomous Region people's Hospital.Lesions of the thoracic spine (T1-T4) in 8 cases, (C5-C7) in 10 cases, cervical and thoracic segment in 13 cases, involving a total of 2 cases of vertebral body in 7 cases, 3 cases of vertebral body in 14 cases, 4 cases of vertebral body. 3D printing group (group A) 12 cases, non 3D printing group (group B) of 19 cases.All cases were treated with a posterior approach to the treatment of the cervical spinal cord around the spinal cord.After taking regular anti tuberculosis drugs in 6-12 months, follow-up observation of correction of kyphosis and paraplegia recovery, blood sedimentation rate (ESR), C-reactive protein (CRP) changes. Results: All cases were followed up for at least 6 months. Twelve patients were treated with 3D printing technique before operation, and the operation was performed according to the preoperative plan.The diameter and length of pedicle screws, the direction of insertion, and the distance between the insertion point and the posterior midline of the pedicle screw were similar to those in the 3D.Three days after the operation, the effect of fracture reduction was satisfactory, and the position of pedicle screws was good.After 6 months of follow-up, the X-ray showed that the pedicle screws were in good position, and there was no loosening and fracture.All the patients were healed, and there was no segmental instability.3D printing group during surgery bleeding, operation time, postoperative drainage volume, compared with the non 3D print group of surgical results, 3D printing group significantly reduce the surgical trauma[(131±18) min vs (162±23), P<0.01; (528±34) ml vs (615±41) ml, P<0.01; (257±46) vs (327±56), P<0.01; (not grouping, before after operation), (64±42) mm/1 h vs (6±7) mm/1 h, P<0.01; CRP (not packet): (72±41) μg/L, (13±6) mm/1 h, P<0.01]. There was significant difference between two groups.The JOA scores of patients in the 3D group were better than those in the non 3D group after the operation in 1, 2 week and in 1, 3, and month.There was no significant difference between the two groups after the operation.Two groups of patients before and after correction of Cobb angle were satisfied, and no significant difference between the two groups.Cobb lost an average of 1 degrees angle correction.The spinal tuberculosis in this group were cured without serious complications. Conclusions: According to the cervical and thoracic tuberculous kyphosis and paraplegia severity, choose a posterior surgery can achieve effective cure, feasible thorough debridement with fixed spinal stability before and after the party obtained bone fusion and deformity correction in 3D technology to increase the accuracy and safety of operation, and can be provide more detailed preoperative, intuitive, three-dimensional, realistic personalized operation scheme.It can reduce the operation trauma, and achieve rapid recovery after operation.

Teaching experience of cardiac surgery rotation for standardized training residents not majoring in cardiac surgery

Cardiac surgery is the latest and fastest growing subject in surgery, which is characterized by complex diseases and strong specialization. The standardized training of non cardiac surgery is short of time for the residents in cardiac surgery, and the teaching has certain complexity and particularity. The department of cardiac surgery of the Xinjiang Uygur Autonomous Region people's Hospital has analyzed the subject characteristics of the major, and explored the reform of cardiac surgery teaching. We adopted a variety of teaching forms to enhance clinical thinking ability and clinical practice ability as the focus of training, and strengthen clinical operation skills according to individual differences among residents. We improved the enthusiasm and initiative of the non-cardiac surgery residents to learn, training residents standardized, standardized diagnosis and treatment behavior, improve the quality of training. Key words: Cardiac surgery; Standardized training of resident; Teaching

Application value of the preoperative multi-slice spiral computed tomography for the repair of huge abdominal incisional hernia

Objective To explore the application value of the preoperative multi-slice spiral computed tomography (MSCT) for the repair of huge abdominal incisional hernia. Methods The retrospective cross-sectional study was conducted. The clinical data of 61 patients with huge abdominal incisional hernia who were admitted to the Xinjiang Uygur Autonomous Region People′s Hospital from January 2012 to February 2016 were collected. All patients underwent preoperative MSCT and three-dimensional reconstruction to measure the percentage of volumes of the hernia sac and abdominal cavity and then selected the individualized surgical methods according to the percentage, and length of small intestine resected was calculated in patients undergoing initiative volume reduction combined with onlay repair. Observation indicators: (1) pre- and post-operative situations: percentage of volumes of the hernia sac and abdominal cavity, duration of preoperative hospital stay, surgical procedure, length of small intestine resected in patients undergoing initiative volume reduction combined with onlay repair, operation time and volume of intraoperative blood loss; (2) postoperative recovery situation: intra-abdominal pressure at postoperative 48 hours, recovery time of postoperative gastrointestinal function, removal time of postoperative abdominal drainage-tube, postoperative complications and duration of postoperative hospital stay; (3) follow-up. Follow-up using outpatient examination and telephone interview was performed to detect the postoperative hernia recurrence and long-term complications up to March 2017. Measurement data with normal distribution were represented as ±s and measurement data with skewed distribution were described as M (range). Results (1) Pre- and post-operative situations: percentage of volumes of the hernia sac and abdominal cavity in 61 patients was 19%±4%, and duration of preoperative hospital stay was (7±5)days. All the 61 patients underwent successful operation, including 48 receiving onlay repair and 13 receiving initiative volume reduction combined with onlay repair, without conversion to other surgery. Length of small intestine resected in 13 patients undergoing initiative volume reduction combined with onlay repair was (48±8)cm. Operation time and volume of intraoperative blood loss in 61 patients were (2.6±0.8)hours and (82±50)mL. (2) Postoperative recovery situation: intra-abdominal pressure at postoperative 48 hours, recovery time of postoperative gastrointestinal function and removal time of postoperative abdominal drainage-tube in 61 patients were (9.6±2.9)mmHg (1 mmHg=0.133kPa), (2.1±0.9)days and (3.5±1.1)days, respectively. Twelve patients had postoperative complications, and grade Ⅰ intra-abdominal hypertension, grade Ⅱ intra-abdominal hypertension, incisional effusion, incisional infection, incisional sinus, mesh infection and urinary retention were respectively detected in 4, 2, 4, 2, 1, 1, 1 in patients undergoing the onlay repair and 2, 1, 1, 0, 0, 0, 0 in patients undergoing initiative volume reduction combined with onlay repair. Some patients had 2 or more of complications. There was no occurrence of abdominal compartment syndrome and perioperative death. Patients with complications were cured or improved by symptomatic treatment. Duration of postoperative hospital stay in 61 patients was (8±4)days. (3) Follow-up: all the patients were followed up for 6-36 months, with a median time of 19 months. During follow-up, 2 patients with recurrence of huge abdominal incisional hernia received tentative follow-up, and were suggested to treat risk factors of recurrence firstly and then undergo reoperations. Other patients didn′t have long-term complications. Conclusion MSCT can provide the accurate data of percentage of volumes of the hernia sac and abdominal cavity before repair of huge abdominal incisional hernia, it also has the important clinical value of choosing the individualized surgical method, preserving the maximum out of normal organs in initiative volume reduction combined with onlay repair and increasing surgical outcomes. Key words: Abdominal incisional hernia, huge; Hernia repair; Multiplanar reconstruction; Tomography

Experience of management of 21 cases enteric fistula after surgery

Objective To review the causes of 21 cases of exteric fistula after surgery, treatment and prognosis, and to explore the clinical treatment of exteric fistula after surgery. Methods To collection the Xinjiang Uygur Autonomous Region People′s Hospital of Gastrointestinal Surgery from Aug 2013 to Aug. 2016 admitted during the period of parenteral fistula patients after abdominal surgery, 21 patients with intestinal fistula outside, 12 cases were male, 9 were female cases. According to the case records of descriptive statistics, the treatment methods was summarized and analyzed retrospectively. Results Au patients with intestinal fistula outside, 12 cases were male, female 9 cases. Conservative treatment of 11 cases, healing in 2 cases, 5 cases, 4 cases died and the sigmoid colon perforation repair 1 case, postoperative ileus postoperative renal function failure in 1 case, gastric cancer by intraperitoneal hemorrhage after early postoperative restrictive ploration in 2 cases; Early surgical treatment of 10 cases, of which the deterministic operation in 1 case, late deterministic surgery in 9, were cured. Conclusions The early diagnosis of parenteral fistula and rapid processing, taken on the basis of the condition of the patients with timely complete drainage, infection control, reasonable nutrition support and correct homeostasis imbalance as the main content of a comprehensive individualized treatment, most patients can improve the self-healing, cannot heal patients to choose the appropriate surgical timing and proper operation method, can improve the cure rate and reduce the case fatality rate. Key words: Enteric fistula; Therapeutic uses; Surgical procedures, operative; Prognosis

Analysis of the efficacy of laparoscopic Toupet fundoplication treatment of hiatal hernia combined with gastroesophageal reflux disease

Objective To explore the efficacy of laparoscopic Toupet fundoplication treatment of hiatal hernia combined with gastroesophageal reflux disease. Methods Forty one patients' medical record information of hiatal hernia combined with gastroesophageal reflux disease that underwent laparoscopic Toupet fundoplication were collected in Xinjiang Uygur Autonomous Region People's Hospital from October 2012 to October 2015. Thirty six cases were adopted pure hiatal hernia suture, 2 cases were used biological patch repair, 1 case used Johnson PHY patch repair, 1 case used Bade patch repair, and 1 case used Tyco hiatal hernia dedicated anti-blocking patch repair. These patients were carried out 24 hours esophageal pH monitoring, esophageal manometry, gastroesophageal reflux disease questionnaire (GERDQ) score and postoperative complications before surgery and 6 months postoperative. The clinical efficacy of laparoscopic Floppy Nissen fundoplication treatment of hiatal hernia combined with gastroesophageal reflux disease was retrospectively analyzed. Results There was no perioperative deaths and serious complications during perioperation. The reflux symptoms were significantly improved postoperative. There was significantly lower in reflux time , the number of reflux (29.83±19.71), acid reflux time percentage , and DeMeester score (7.28±7.38) than the preoperative . GERD Q scale score (7.18±1.33) was significantly lower than preoperative (10.91±2.02) with statistically significant difference (P<0.05). lower esophagealsphincter (LES) pressure was significantly increased than preoperative . Residual pressure was significantly increased than preoperative . Relaxation rate was significantly reduced than preoperative . However, swallowing invalid was increased than preoperative , with statistically significant difference (P<0.05). The median follow-up was 10 months, and there was no recurrence during follow-up. Conclusions Laparoscopic Toupet fundoplication can effectively inhibit reflux symptoms, and increase LES pressure, which is worthy of promotion. However, there is slightly higher incidence of postoperative dysphagia. Key words: Laparoscopy; Fundoplication; Hernia, hiatal/CO/SU; Gastroesophageal reflux/CO/SU

Wnt1 and SFRP1 as potential prognostic factors and therapeutic targets in cutaneous squamous cell carcinoma.

The Wnt signaling pathway plays a key role in insurgence and progression of many different forms of cancer. Some crucial components of the Wnt pathway have been proposed to be novel targets for cancer therapy. To date, the Wnt signaling pathway has not been studied in cutaneous squamous cell carcinoma (CSCC). This study was designed to investigate the expression of Wnt1 and SFRP1 from the Wnt pathway in CSCC. Tissue samples were obtained from 35 patients with CSCC and 30 controls admitted to the Xinjiang Uygur Autonomous Region People's Hospital at Urumchi City, China. Gene and protein expressions of Wnt1 and SFRP1 were quantified by immunohistochemistry and western blotting. Wnt1 expression was significantly higher (P < 0.05) in CSCC samples than in normal skin cells of the control subjects; in contrast, SFRP1 expression was significantly lower in CSCC tissues than that in tissues of control subjects (P < 0.05). Moreover, Wnt1 expression (P < 0.05) was found to be correlated with histopathological differentiation in CSCC, and negatively correlated with SFRP1 expression in CSCC (rs = -0.473, P = 0.015). Therefore, we concluded that Wnt1 and SFRP1 play important roles in the development of CSCC and could be potent markers for diagnosis, prevention, and therapy of CSCC.

The significance of PET-CT on staging in multiple myeloma

Objective To investigate the staging significance of PET-CT in multiple myeloma, and to observe the relationship between baseline PET-CT and clinical parameters in multiple myeloma. Methods 78 cases newly diagnosed MM patients were selected from the Department of Hematology, the Xinjiang Uygur Autonomous Region people's Hospital from March 2007 to February 2014, with average age 61.24 years old. The levels of hemoglobin, albumin, beta 2 microglobulin and lactate dehydrogenase were detected before the treatment. PET-CT was performed to measure SUVmax in the spine, pelvis and rib with an average of the SUVmax in each case, and the number of FDG-avid focal lesions in every patient was counted. The difference of the SUVmax or FLS in different stages and the relationship between SUVmax or FLS and clinical parameters in MM were observed. Results All the patients were divided into 3 stages depending on ISS staging. The average SUV values in 10 cases of stage Ⅰ, 45 cases of stage Ⅱ and 23 cases of stage Ⅲ were 1.84±0.28, 3.74±0.42 and 6.02±0.93, respectively, and SUV values was significantly different among different groups (P<0.05). SUV values were positively correlated with levels of beta 2 microglobulin (r=0.862, P<0.001) and lactate dehydrogenase (r=0.592, P<0.001), and negatively correlated with albumin (r=-0.762, P<0.001) and hemoglobin levels (r=-0.685, P<0.001). The number of lesions had a correlation with low hemoglobin, high lactate dehydrogenase and high beta 2 microglobulin (P<0.05). Conclusion PET-CT can reflect tumor burden to some extent, and has the guiding significance for MM stage, which contributes to developing individualized treatment programs. Key words: Multiple myeloma; Positron emission tomography-computed tomography; Stage