On 12 May 2008, the devastating Wenchuan earthquake struck the Longmenshan fault zone, which comprised the eastern margin of the Tibetan Plateau, and this fault zone was predominantly a convergent boundary with a right-lateral strike-slip component. After such a large-magnitude earthquake, it was crucial to analyze the influences of the earthquake on the surrounding faults and the potential seismic activity. In this paper, a complex viscoelastic model of western Sichuan and eastern Tibet regions was constructed including the topography. Based on the findings of co-seismic static slip distribution, we calculated the stress change caused by the Wenchuan earthquake with the post-seismic relaxation into consideration. Our preliminary results indicated that: (1) The tectonic stressing rate was relatively high in Kunlun mountain pass-Jiangcuo, Ganzi-Yushu, Xianshuihe and Zemuhe faults; while in the east Kunlun and Longriba was medium; also the value was less in the Minjiang, Longmenshan, Anninghe and Huya faults. As to the Longmenshan fault, the value was 0.28×10−3 MPa/a to 0.35×10−3 MPa/a, which is coincident with the previous long recurrence interval of Wenchuan earthquake; (2) The Wenchuan earthquake not only caused the Coulomb stress decrease in the source region, but also the stress increase in the two terminals, especially the northeastern segment, which is comparatively consistent with the aftershock distribution. Meanwhile, the high concentration areas of the static slip distribution were corresponding to the Coulomb stress reductions; (3) The Coulomb stress change caused by Wenchuan earthquake showed significant increase on five major faults, which were northwestern segment of Xianshuihe fault, eastern Kunlun fault, Longriba fault, Minjiang fault and Huya fault respectively; also the Coulomb stress on the fault plane of the Yushu earthquake was faintly increased; (4) We defined the recurrence interval as the time needed to accumulate the magnitude of the stress drop, and the recurrence interval of Wenchuan earthquake was estimated about 1 714 a to 2 143 a correspondingly.