X-ray Image Data Research Articles

How Wetting and Drainage Cycles and Wetting Angle Affect Capillary Air Trapping and Hydraulic Conductivity: A Pore Network Modeling of Experiments on Sand

Entrapped air in porous media can significantly affect water flow but simulations of air entrapment are still challenging. We developed a pore-network model using quasi-static algorithms to simulate air entrapment during spontaneous wetting and subsequent drainage processes. The model, implemented in OpenPNM, was tailored to replicate an experiment conducted on a medium-sized unconsolidated sand sample. We started building the model with three types of relatively small networks formed by 54,000 pore bodies which we used to calibrate basic network topological parameters by fitting the model to the water retention curve and the saturated hydraulic conductivity of the sand sample. Using these parameters, along with X-ray image data (µCT), a larger network formed by over 250,000 pore bodies was introduced in the form of stacked sub-networks where topological parameters were scaled along the z-axis. We investigated the impact of two different contact angles on air entrapment. For a contact angle of 0, the model showed good agreement with the experimental data, accurately predicting the amount of entrapped air and the saturated hydraulic conductivity. On the contrary, for a contact angle of π/4, the model provided reasonable accuracy for saturated hydraulic conductivity but overestimated the amount of entrapped air. Overall, this approach demonstrated that a reasonable match between simulated and experimental data can be achieved with minimal computational costs.

"Enhancing Lung Cancer Detection: A Comparative Analysis of CNN and RNN Models on X-Ray Image Data"

"Enhancing Lung Cancer Detection: A Comparative Analysis of CNN and RNN Models on X-Ray Image Data"

Assessing Compatibility of Advanced IC Packages to X-ray Based Physical Inspection

Abstract This article describes a proposed novel metric to furnish chip designers with a prognostic tool for x-ray imaging in the pre-silicon stage. This metric is fashioned to provide designers with a concrete measure of how visible the fine-pitched features of their designs are under x-ray inspection. It utilizes a combination of x-ray image data collection, analysis, and simulations to evaluate different design elements.

Implementasi Algoritma K-Means dan Knearest Neighbors (KNN) Untuk Identifikasi Penyakit Tuberkulosis Pada Paru-Paru

In Indonesia, tuberculosis is ranked third in terms of prevalence among countries with the highest tuberculosis burden. Radiological examination, such as X-rays or X-rays, is a method generally used to detect tuberculosis. Chest X-ray examination is one method used to detect tuberculosis. To achieve these goals, the research will combine two powerful data processing techniques. First, the K-Means algorithm will be used to group x-ray image data based on similar characteristics, making it easier to identify typical patterns from images infected with tuberculosis. The research results show the highest accuracy of 93% using data division with a ratio of 80 : 20 with parameter K = 1. These results show that the combined model of the two algorithms can be applied to identify tuberculosis in the lungs.

Development of an artificial intelligence-based multimodal model for assisting in the diagnosis of necrotizing enterocolitis in newborns: a retrospective study.

The purpose of this study is to develop a multimodal model based on artificial intelligence to assist clinical doctors in the early diagnosis of necrotizing enterocolitis in newborns. This study is a retrospective study that collected the initial laboratory test results and abdominal x-ray image data of newborns (non-NEC, NEC) admitted to our hospital from January 2022 to January 2024.A multimodal model was developed to differentiate multimodal data, trained on the training dataset, and evaluated on the validation dataset. The interpretability was enhanced by incorporating the Gradient-weighted Class Activation Mapping (GradCAM) analysis to analyze the attention mechanism of the multimodal model, and finally compared and evaluated with clinical doctors on external datasets. The dataset constructed in this study included 11,016 laboratory examination data from 408 children and 408 image data. When applied to the validation dataset, the area under the curve was 0.91, and the accuracy was 0.94. The GradCAM analysis shows that the model's attention is focused on the fixed dilatation of the intestinal folds, intestinal wall edema, interintestinal gas, and portal venous gas. External validation demonstrated that the multimodal model had comparable accuracy to pediatric doctors with ten years of clinical experience in identification. The multimodal model we developed can assist doctors in early and accurate diagnosis of NEC, providing a new approach for assisting diagnosis in underdeveloped medical areas.

An optimal deep learning model for the scoring of radiographic damage in patients with ankylosing spondylitis.

Detecting vertebral structural damage in patients with ankylosing spondylitis (AS) is crucial for understanding disease progression and in research settings. This study aimed to use deep learning to score the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) using lateral X-ray images of the cervical and lumbar spine in patients with AS in Asian populations. A deep learning model was developed to automate the scoring of mSASSS based on X-ray images. We enrolled patients with AS at a tertiary medical center in Taiwan from August 1, 2001 to December 30, 2020. A localization module was used to locate the vertebral bodies in the images of the cervical and lumbar spine. Images were then extracted from these localized points and fed into a classification module to determine whether common lesions of AS were present. The scores of each localized point were calculated based on the presence of these lesions and summed to obtain the total mSASSS score. The performance of the model was evaluated on both validation set and testing set. This study reviewed X-ray image data from 554 patients diagnosed with AS, which were then annotated by 3 medical experts for structural changes. The accuracy for judging various structural changes in the validation set ranged from 0.886 to 0.985, whereas the accuracy for scoring the single vertebral corner in the test set was 0.865. This study demonstrated a well-trained deep learning model of mSASSS scoring for detecting the vertebral structural damage in patients with AS at an accuracy rate of 86.5%. This artificial intelligence model would provide real-time mSASSS assessment for physicians to help better assist in radiographic status evaluation with minimal human errors. Furthermore, it can assist in a research setting by offering a consistent and objective method of scoring, which could enhance the reproducibility and reliability of clinical studies.

Pneumonia and tuberculosis detection with chest x-ray images and medical records using deep learning techniques

Pneumonia and tuberculosis are the major public health problems worldwide. These diseases affect the lungs, and if they are not diagnosed properly in time, they can become a fatal health problem. Chest x-ray images are widely used to detect and diagnose Pneumonia and Tuberculosis disease. Detection of Pneumonia and Tuberculosis from chest x-ray images is difficult and requires experience due to the similar pathological features of the diseases. Sometimes a misdiagnosis of the disease occurs due to this similarity. Several researchers used deep learning and machine learning techniques to solve this misdiagnosis problem. However, these studies used the chest x-ray images only to develop Pneumonia and Tuberculosis disease detection models. But using the chest x-ray images alone cannot necessarily lead to accurate disease detection and classification. In the traditional or manual approach, medical records are required to support and correctly interpret the chest x-ray images in the appropriate clinical context. This study develops a multi-input Pneumonia and Tuberculosis detection model using chest x-ray images and medical records to follow the clinical procedure. The study applied a Convolutional Neural Network for the chest x-ray image data and a Multilayer perceptron for the medical record data to develop the models. We implemented feature-level concatenation to join the output feature vectors from the Convolutional Neural Network and a Multilayer perceptron for the development of the disease detection model. For the purpose of comparison, we also developed image-only and medical record-only models. Consequently, the image-only model gives an accuracy of 92.68%, the medical record-only model results in 98.72% accuracy, and the combined model accuracy is improved to 99.61%. In general, the study shows that the fusion of the chest x-ray and the medical records leads to better accuracy and is more similar to the clinical approach.

Classification of Pneumonia and Covid-19 using Convolutional Neural Network

Purpose: The early and exact classification and identification is necessary for proper treatment which needs excessive time and effort of professionals. This examination is meant to foster a task to recognize Pneumonia and Coronavirus utilizing the idea of the Convolutional Neural Network (CNN) for picture grouping and is centered on building the profound learning model that aids in the characterization utilizing chest X-beam pictures in one of the quick and financially savvy ways. Design/Methodology/Approach: This study uses a wide dataset comprising of chest X-beam pictures accumulated from the Mendeley dataset. Include extraction strategies like picture pre-handling and data augmentation are applied to improve the arrangement execution. The framework utilizes the ResNet-18, which is a sort of CNN model for order. The examination includes assessing the exactness, accuracy, review, F1 score, and area under the receiver working trademark bend (AUC-ROC) for every classification model. Findings/Result: The dataset is separated into preparing and testing subsets to ensure unbiased performance evaluation. For the development and deployment of an accurate and reliable system, factors like data quality, model interpretability, and ethical considerations are considered. We successfully used the pre-trained ResNet-18 CNN model with chest X-ray image data that helped to build a robust classification system with a learning rate of 0.0001 and epoch size 10 having approx. 98.12% train accuracy and 97.70% test accuracy. Since the start of the project, we researched several methodologies to build the system. The other models (e.g., ResNet-50) were too big algorithms for our problem which created a problem of overfitting. Hence performance was not very accurate. So, we planned to go with the ResNet-18 model. As per our plan, we developed a system that operates as expected. Originality/Value: It helps medical professionals in diagnosing and managing these diseases. Paper Type: Research paper

GLCM-Based FBLS: A Novel Broad Learning System for Knee Osteopenia and Osteoprosis Screening in Athletes

Due to the physical strain experienced during intense workouts, athletes are at a heightened risk of developing osteopenia and osteoporosis. These conditions not only impact their overall health but also their athletic performance. The current clinical screening methods for osteoporosis are limited by their high radiation dose, complex post-processing requirements, and the significant time and resources needed for implementation. This makes it challenging to incorporate them into athletes’ daily training routines. Consequently, our objective was to develop an innovative automated screening approach for detecting osteopenia and osteoporosis using X-ray image data. Although several automated screening methods based on deep learning have achieved notable results, they often suffer from overfitting and inadequate datasets. To address these limitations, we proposed a novel model called the GLCM-based fuzzy broad learning system (GLCM-based FBLS). Initially, texture features of X-ray images were extracted using the gray-level co-occurrence matrix (GLCM). Subsequently, these features were combined with the fuzzy broad learning system to extract crucial information and enhance the accuracy of predicting osteoporotic conditions. Finally, we applied the proposed method to the field of osteopenia and osteoporosis screening. By comparing this model with three advanced deep learning models, we have verified the effectiveness of GLCM-based FBLS in the automatic screening of osteoporosis for athletes.

CHEST X-RAY IMAGE SEGMENTATION USING MODIFIED DEEPLABV3+ METHOD

COVID-19 is a disease that affects the human respiratory system. The latest developments in September 2022 the number of confirmed cases of COVID-19 worldwide reached 608,328,548 with 6,501,469 patients who died. While in Indonesia confirmed COVID-19 reached 6,408,806 with 157,892 patients who died. Reserve Transcription Polymerase Chain Reaction (RT-PCR) is the most widely used tool. However, the latest RT-PCR test report shows that the RT-PCR test is inadequate. As an alternative, radiographic images such as chest x-rays and CT scans can help detect this. Radiographic images, especially x-rays, need processing to be able to make a diagnosis. Computer Aided Diagnosis (CAD) is a computer assisted diagnosis system that can be used as supporting information in making a diagnosis. To make it easier to make a diagnosis, we need a deep learning model that can help with this. DeepLabV3+ is a method that can carry out the segmentation process. DeepLabV3+ which is an extension of DeepLabV3 with the aim of improving the segmentation results. DeepLabV3+ uses a modified Xception as the backbone. In this study, 1,500 chest x-ray image data were used which were then divided into 80% for training data and 20% for testing data. There are 4 test scenarios in this study, namely with a learning rate of 0.01 without CLAHE, a learning rate of 0,01 and using CLAHE, a learning rate of 0,0001 without CLAHE, and a learning rate of 0,0001 using CLAHE. Of the 4 scenarios the learning rate scenario is 0,01 and using CLAHE gets the highest evaluation results using the Dice Similarity Coefficient (DSC) of 96.91%.

A Robust Hybrid Deep Convolutional Neural Network for COVID-19 Disease Identification from Chest X-ray Images

The prompt and accurate identification of the causes of pneumonia is necessary to implement rapid treatment and preventative approaches, reduce the burden of infections, and develop more successful intervention strategies. There has been an increase in the number of new pneumonia cases and diseases known as acute respiratory distress syndrome (ARDS) as a direct consequence of the spread of COVID-19. Chest radiography has evolved to the point that it is now an indispensable diagnostic tool for COVID-19 infection pneumonia in hospitals. To fully exploit the technique, it is crucial to design a computer-aided diagnostic (CAD) system to assist doctors and other medical professionals in establishing an accurate and rapid diagnosis of pneumonia. This article presents a robust hybrid deep convolutional neural network (DCNN) for rapidly identifying three categories (normal, COVID-19 and pneumonia (viral or bacterial)) using X-ray image data sourced from the COVID-QU-Ex dataset. The proposed approach on the test set achieved a rate of 99.25% accuracy, 99.10% Kappa-score, 99.43% AUC, 99.24% F1-score, 99.25% recall, and 99.23% precision, respectively. The outcomes of the experiments demonstrate that the presented hybrid DCNN mechanism for identifying three categories utilising X-ray images is robust and effective.

Pneumonia Detection using Convolutional Neural Network (CNN)

Pneumonia Is A Dangerous And Sometimes Fatal Disease That Primarily Affects Older People. Early Diagnosis Of Pneumonia Is Key To Saving Many Lives. This Study Attempted To Identify And Classify Patients With Pneumonia Based On Chest X-Rays. The Diagnostics Above Were Performed Using A Convolutional Neural Network, Which Was Built From The Ground Up And Produced Incredibly Accurate Results. When X-Raying A Patient, A Deep Learning Model Automates The Procedure And Ensures Fast, Competent And Efficient Results. This study Prioritizes A Convolutional Neural Network Model Trained On X-Ray Image Data To Distinguish And Diagnose Pneumonia. Convolutional Neural Network Models Were Used To Determine If A Person Had Pneumonia By Isolating Features From Specific X-Ray Chest Images, Compared To Previous Methods That Relied On Transfer Learning Techniques Or Traditional Manual Methods To Isolate Features Differently. They Overcome Liability And Reliability Issues When Creating Images.

Detection of Lung Cancer diseases Based on CT SCAN Images using Deep Learning

Abstract: Increased health risks originate from changes in the natural surroundings, climate, and way of life. India is the leading nation in respiratory illness mortality. They were always the second-leading mortality cause globally in 2017 behind heart disease, claiming the lives of 1 million (958,000) Indians. Severe effects of lung cancer, especially death, can be avoided by timely detection and treatment. The better diagnostic technique at the present is a chest X-ray, which is necessary for clinical therapy. By using Deep Learning to detect lung diseases from chest X-rays, a person with lung disease may be able to save their own life. Lung tumor is yet another name for lung cancer. It is a malignant tumor illness that causes uncontrolled cellular proliferation in the lung tissue. The much more common sources of lung cancer by just using tobacco products and smoking. One of the most common causes of death in the entire world is lung cancer. The ResNet-50 (Residual Network) pre-trained Deep Learning model used for image classification of the Convolutional Neural Network is a very successful method. Neural network (also known as Convolution or CNN). ResNet-50, which now has 50 layers, has been trained using just a million images from the ImageNet database in 1000 various categories. The ability to forecast outcomes quickly and accurately tends to make this possible. This paper presents a practical strategy for just using deep learning to recognize lung problems. Its primary objective is to develop a method that will assist radiologists to identify lung problems. This will be especially beneficial in remote locations in which radiologists are in short supply. To evaluate the efficacy and correctness of various models for trying to identify lung cancer from chest x-ray image data, the RESNET 50 model is used.

Multi-label classification of chest X-ray images with pre-trained vision Transformer model

目的 基于计算机的胸腔X线影像疾病检测和分类目前存在误诊率高，准确率低的问题。本文在视觉Transformer（vision Transformer，ViT）预训练模型的基础上，通过迁移学习方法，实现胸腔X线影像辅助诊断，提高诊断准确率和效率。方法 选用带有卷积神经网络（convolutional neural network，CNN）的ViT模型，其在超大规模自然图像数据集中进行了预训练；通过微调模型结构，使用预训练的ViT模型参数初始化主干网络，并迁移至胸腔X线影像数据集中再次训练，实现疾病多标签分类。结果 在IU X-Ray数据集中对ViT迁移学习前、后模型平均AUC（area under ROC curve）得分进行对比分析实验。结果表明，预训练ViT模型平均AUC得分为0.774，与不使用迁移学习相比提升了0.208。并针对模型结构和数据预处理进行了消融实验，对ViT中的注意力机制进行可视化，进一步验证了模型有效性。最后使用Chest X-Ray14和CheXpert数据集训练微调后的ViT模型，平均AUC得分为0.839和0.806，与对比方法相比分别有0.014～0.031的提升。结论 与其他方法相比，ViT模型胸腔X线影像的多标签分类精确度更高，且迁移学习可以在降低训练成本的同时提升ViT模型的分类性能和泛化性。消融实验与模型可视化表明，包含CNN结构的ViT模型能重点关注有意义的区域，高效获取胸腔X线影像的视觉特征。;Objective The chest X-ray-relevant screening and diagnostic method is essential for radiology nowadays. Most of chest X-ray images interpretation is still restricted by clinical experience and challenged for misdiagnose and missed diagnoses. To detect and identify one or more potential diseases in images automatically，it is beneficial for improving diagnostic efficiency and accuracy using computer-based technique. Compared to natural images，multiple lesions are challenged to be detected and distinguished accurately in a single image because abnormal areas have a small proportion and complex representations in chest X-ray images. Current convolutional neural network（CNN）based deep learning models have been widely used in the context of medical imaging. The structure of the CNN convolution kernel has sensitive to local detail information，and it is possible to extract richer image features. However，the convolution kernel cannot be used to get global information，and the features-extracted are restricted of redundant information like its relevance of background， muscles，and bones. The model’s performance in multi-label classification tasks are affected to a certain extent. At present，the vision Transformer（ViT）model has achieved its priorities in computer vision-related tasks. The ViT can be used to capture information simultaneously and effectively for multiple regions of the entire image. However，it is required to use large-scale dataset training to achieve good performance. Due to some factors like patient privacy and manual annotate costs，the size of the chest X-ray image data set has been limited. To reduce the model's dependence on data scale and improve the performance of multi-label classification，we develop the CNN-based ViT pre-training model in terms of the transfer learning method for diagnosis-assisted of chest X-ray image and multi-label classification. Method The CNN-based ViT model is pre-trained on a huge scale ground truth dataset，and it is used to obtain the initial parameters of the model. The model structure is fine-tuned according to the features of chest X-ray dataset. A 1×1 convolution layer is used to convert the chest X-ray images channels between 1 to 3. The number of output nodes of the linear layer in the classifier is balanced from 1 000 to the number of chest X-ray classification labels，and the Sigmoid is used as an activation function. The parameters of the backbone network are initialized in terms of the pre-trained ViT model parameters，and it is trained in the chest X-ray dataset after that to complete multi-label classification. The experiment is configured of Python3. 7 and PyTorch1. 8 to construct the model and RTX3090 GPU for training. Stochastic gradient descent（SGD）optimizer，binary cross-entropy（BCE）loss function，an initial learning rate of 1E-3，the cosine annealing learning rate decay are used. For training，each image is scaled to a size of 512×512 pixels，and a 224×224 pixels area and it is then cropped in random as the model input，and data augmentation is performed randomly by some of the flipping，perspective transformation， shearing，translation，zooming，and changing brightness. For testing，the chest X-ray image is scaled to 256×256 pixels and center crop a 224×224 area to input the trained model. Result The experiment is performed on the IU X-Ray，which is a small-scale chest X-ray dataset. This model is evaluated in quantitative using the average of area under ROC curve （AUC）scores across all classification labels. The results show that the average AUC score of the pre-trained ViT model is 0. 774. The accuracy and training efficiency of the non-pre-trained ViT model is dropped significantly. The average AUC score is reached to 0. 566 only，which is 0. 208 lower. In addition，the attention mechanism heat map is generated based on the ViT model，which can strengthen the interpretability of the model. A series of ablation experiments are carried out for data augmentation，model structure，and batch size design. The fine-tuned ViT model is trained on the Chest-Ray14 and CheXpert dataset as well. The average AUC score is reached to 0. 839 and 0. 806，which is optimized by 0. 014 and 0. 031. Conclusion A pre-trained ViT model is used for the multi-label classification of chest X-ray images via transfer learning. The experimental results illustrate that the ViT has its stronger multi-label classification performance in chest Xray images，and its attention mechanism is beneficial for lesions precision-focused like the interior of the chest cavity and the heart. Transfer learning is potential to improve the classification performance and model generalization of the ViT in small-scale datasets，and the training cost is reduced greatly. Ablation experiments demonstrate that the incorporated model of CNN and Transformer has its priority beyond single-structure model. Data enhancement and the batch size cutting can improve the performance of the model，but smaller scale of batch is still interlinked to longer training span. To improve the model's ability，we predict that future research direction can be focused on the extraction for complex disease and highlevel semantic information，such as their small lesions，disease location，and severity.

Lightweight deep learning methods for panoramic dental X-ray image segmentation

Dental X-ray image segmentation is helpful for assisting clinicians to examine tooth conditions and identify dental diseases. Fast and lightweight segmentation algorithms without using cloud computing may be required to be implemented in X-ray imaging systems. This paper aims to investigate lightweight deep learning methods for dental X-ray image segmentation for the purpose of deployment on edge devices, such as dental X-ray imaging systems. A novel lightweight neural network scheme using knowledge distillation is proposed in this paper. The proposed lightweight method and a number of existing lightweight deep learning methods were trained on a panoramic dental X-ray image data set. These lightweight methods were evaluated and compared by using several accuracy metrics. The proposed lightweight method only requires 0.33 million parameters (sim 7.5 megabytes) for the trained model, while it achieved the best performance in terms of IoU (0.804) and Dice (0.89) comparing to other lightweight methods. This work shows that the proposed method for dental X-ray image segmentation requires small memory storage, while it achieved comparative performance. The method could be deployed on edge devices and could potentially assist clinicians to alleviate their daily workflow and improve the quality of their analysis.

Double-Lumen Endotracheal Tube-Predicting Insertion Depth and Tube Size Based on Patient's Chest X-ray Image Data and 4 Other Body Parameters.

In thoracic surgery, the double lumen endotracheal tube (DLT) is used for differential ventilation of the lung. DLT allows lung collapse on the surgical side that requires access to the thoracic and mediastinal areas. DLT placement for a given patient depends on two settings: a tube of the correct size (or 'size') and to the correct insertion depth (or 'depth'). Incorrect DLT placements cause oxygen desaturation or carbon dioxide retention in the patient, with possible surgical failure. No guideline on these settings is currently available for anesthesiologists, except for the aid by bronchoscopy. In this study, we aimed to predict DLT 'depths' and 'sizes' applied earlier on a group of patients (n = 231) using a computer modeling approach. First, for these patients we retrospectively determined the correlation coefficient (r) of each of the 17 body parameters against 'depth' and 'size'. Those parameters having r > 0.5 and that could be easily obtained or measured were selected. They were, for both DLT settings: (a) sex, (b) height, (c) tracheal diameter (measured from X-ray), and (d) weight. For 'size', a fifth parameter, (e) chest circumference was added. Based on these four or five parameters, we modeled the clinical DLT settings using a Support Vector Machine (SVM). After excluding statistical outliers (±2 SD), 83.5% of the subjects were left for 'depth' in the modeling, and similarly 85.3% for 'size'. SVM predicted 'depths' matched with their clinical values at a r of 0.91, and for 'sizes', at an r of 0.82. The less satisfactory result on 'size' prediction was likely due to the small target choices (n = 4) and the uneven data distribution. Furthermore, SVM outperformed other common models, such as linear regression. In conclusion, this first model for predicting the two DLT key settings gave satisfactory results. Findings would help anesthesiologists in applying DLT procedures more confidently in an evidence-based way.

Nomogram model based on radiomics signatures and age to assist in the diagnosis of knee osteoarthritis

BackgroundKnee osteoarthritis (KOA) is a common disease in the elderly. An effective method for accurate diagnosis could affect the management and prognosis of patients. ObjectivesTo develop a nomogram model based on X-ray imaging data and age, and to evaluate its effectiveness in the diagnosis of KOA. MethodsA total of 4403 knee X-rays from 1174 patients (July 2017 to November 2018) were retrospectively analyzed. Radiomics features were extracted and selected from the X-ray image data to quantify the phenotypic characteristics of the lesion region. Feature selection was performed in three steps to enable the derivation of robust and effective radiomics signatures. Then, logistic regression (LR), support vector machine (SVM) AdaBoost, gradient boosting decision tree (GBDT), and multi-layer perceptron (MLP) was adopted to verify the performance of radiomics signatures. In addition, a nomogram model combining age with radiomics signatures was constructed. At last, receiver operating characteristic (ROC) curve, calibration and decision curves were used to evaluate the discriminative performance. ResultsThe LR model has the best classification performance among the four radiomics models in testing cohort (LR AUC vs. SVM AUC: 0.843 vs. 0.818, DeLong test P = 0.0024; LR AUC vs. GBDT AUC: 0.843 vs. 0.821, P = 0.0028; LR AUC vs. MLP AUC: 0.843 vs. 0.822, P = 0.0019). The nomogram model achieved better predictive efficacy than the radiomics model in testing cohort compared to radiomics models although the statistical difference was not significant (Nomogram AUC vs. Radiomics AUC: 0.847 vs. 0.843, P = 0.06). The decision curve analysis revealed that the constructed nomogram had clinical usefulness. ConclusionThe nomogram model combining radiomics signatures with age has good performance for the accurate diagnosis of KOA and may help to improve clinical decision-making.

A robust COVID-19 mortality prediction calculator based on Lymphocyte count, Urea, C-Reactive Protein, Age and Sex (LUCAS) with chest X-rays

There have been numerous risk tools developed to enable triaging of SARS-CoV-2 positive patients with diverse levels of complexity. Here we presented a simplified risk-tool based on minimal parameters and chest X-ray (CXR) image data that predicts the survival of adult SARS-CoV-2 positive patients at hospital admission. We analysed the NCCID database of patient blood variables and CXR images from 19 hospitals across the UK using multivariable logistic regression. The initial dataset was non-randomly split between development and internal validation dataset with 1434 and 310 SARS-CoV-2 positive patients, respectively. External validation of the final model was conducted on 741 Accident and Emergency (A&E) admissions with suspected SARS-CoV-2 infection from a separate NHS Trust. The LUCAS mortality score included five strongest predictors (Lymphocyte count, Urea, C-reactive protein, Age, Sex), which are available at any point of care with rapid turnaround of results. Our simple multivariable logistic model showed high discrimination for fatal outcome with the area under the receiving operating characteristics curve (AUC-ROC) in development cohort 0.765 (95% confidence interval (CI): 0.738–0.790), in internal validation cohort 0.744 (CI: 0.673–0.808), and in external validation cohort 0.752 (CI: 0.713–0.787). The discriminatory power of LUCAS increased slightly when including the CXR image data. LUCAS can be used to obtain valid predictions of mortality in patients within 60 days of SARS-CoV-2 RT-PCR results into low, moderate, high, or very high risk of fatality.

The KNee OsteoArthritis Prediction (KNOAP2020) challenge: An image analysis challenge to predict incident symptomatic radiographic knee osteoarthritis from MRI and X-ray images

The KNee OsteoArthritis Prediction (KNOAP2020) challenge was organized to objectively compare methods for the prediction of incident symptomatic radiographic knee osteoarthritis within 78 months on a test set with blinded ground truth. The challenge participants were free to use any available data sources to train their models. A test set of 423 knees from the Prevention of Knee Osteoarthritis in Overweight Females (PROOF) study consisting of magnetic resonance imaging (MRI) and X-ray image data along with clinical risk factors at baseline was made available to all challenge participants. The ground truth outcomes, i.e., which knees developed incident symptomatic radiographic knee osteoarthritis (according to the combined ACR criteria) within 78 months, were not provided to the participants. To assess the performance of the submitted models, we used the area under the receiver operating characteristic curve (ROCAUC) and balanced accuracy (BACC). Seven teams submitted 23 entries in total. A majority of the algorithms were trained on data from the Osteoarthritis Initiative. The model with the highest ROCAUC (0.64 (95% confidence interval (CI): 0.57-0.70)) used deep learning to extract information from X-ray images combined with clinical variables. The model with the highest BACC (0.59 (95% CI: 0.52-0.65)) ensembled three different models that used automatically extracted X-ray and MRI features along with clinical variables. The KNOAP2020 challenge established a benchmark for predicting incident symptomatic radiographic knee osteoarthritis. Accurate prediction of incident symptomatic radiographic knee osteoarthritis is a complex and still unsolved problem requiring additional investigation.

IEViT: An enhanced vision transformer architecture for chest X-ray image classification

Background and Objective: Chest X-ray imaging is a relatively cheap and accessible diagnostic tool that can assist in the diagnosis of various conditions, including pneumonia, tuberculosis, COVID-19, and others. However, the requirement for expert radiologists to view and interpret chest X-ray images can be a bottleneck, especially in remote and deprived areas. Recent advances in machine learning have made possible the automated diagnosis of chest X-ray scans. In this work, we examine the use of a novel Transformer-based deep learning model for the task of chest X-ray image classification.Methods: We first examine the performance of the Vision Transformer (ViT) state-of-the-art image classification machine learning model for the task of chest X-ray image classification, and then propose and evaluate the Input Enhanced Vision Transformer (IEViT), a novel enhanced Vision Transformer model that can achieve improved performance on chest X-ray images associated with various pathologies.Results: Experiments on four chest X-ray image data sets containing various pathologies (tuberculosis, pneumonia, COVID-19) demonstrated that the proposed IEViT model outperformed ViT for all the data sets and variants examined, achieving an F1-score between 96.39% and 100%, and an improvement over ViT of up to +5.82% in terms of F1-score across the four examined data sets. IEViT’s maximum sensitivity (recall) ranged between 93.50% and 100% across the four data sets, with an improvement over ViT of up to +3%, whereas IEViT’s maximum precision ranged between 97.96% and 100% across the four data sets, with an improvement over ViT of up to +6.41%.Conclusions: Results showed that the proposed IEViT model outperformed all ViT’s variants for all the examined chest X-ray image data sets, demonstrating its superiority and generalisation ability. Given the relatively low cost and the widespread accessibility of chest X-ray imaging, the use of the proposed IEViT model can potentially offer a powerful, but relatively cheap and accessible method for assisting diagnosis using chest X-ray images.