Two decades of advances in genomics, information technology, and precision medicine hold the promise for better care and improved survival for patients with chronic disorders. Patients expect that the health-care system, especially in countries with a market economy, will continue to offer solutions and cures to many illnesses. Yet, concerns over morbidity and mortality from unsafe health-care practices continue to linger and erode patient confidence. The Institute of Medicine of the U.S. National Academies sounded the alarm on patient safety in a report published 17 years ago and called for an examination of health care practices (Institute of Medicine, 2000). Since then several epidemiological studies have been conducted to determine the extent and causes of, and interventions for, adverse medical events and patient safety (Jha et al., 2013; Kemp, Santana, Southern, McCormack, & Quan, 2016; O'Hagan, MacKinnon, Persaud, & Etchegary, 2009). A survey from Australia, Canada, Germany, the Netherlands, New Zealand, the United Kingdom, and the United States estimated 12 to 20 percent adverse events, with disability more common than mortality, and a higher disability-adjusted life year (DALY) in developing countries (O'Hagan et al., 2009). The authors estimate that seven types of adverse events considered in this study constitute the 20th leading cause of morbidity and mortality for the world's population. In the United States, medical errors and adverse effects (Grober & Bohenen, 2005; Makary & Daniel, 2016) continue to be at the center of controversy and are the subject of continued news media headlines. One in seven U.S. Medicare1 patients experiences a medical error (Agency for Healthcare Research and Quality, 2014). Prescription drugs are reported for nearly 100,000 hospitalizations each year. Many in-patient health institutions (hospitals) are increasingly employing physician hospitalists to care for the admissions. Transitions in care, from one physician to another, or to a hospitalist, can lead to preventable harm related to medications (Graham, Scudder, & Stokowski, 2015; Velo & Minuz, 2009). Many countries and international organizations such as the World Health Organization and the World Medical Association (53rd World Medical Association General Assembly, 2002) have published guidelines to improve patient safety. Most countries with a market economy have established registries for reporting medication adverse events. New tools such as health forecasting (Soyiri & Reidpath, 2013) can assist with better epidemiological data collection and research. Medical errors should be recognized as a standalone diagnostic code in the International Statistical Classification of Diseases and Related Health Problems (ICD) to facilitate the collection of global information on morbidity and mortality and DALY estimates. The global health-care enterprise is diverse, and one of the 20 largest industries financed by governments and private entities. It is estimated that by 2022, health expenditures for the developing (about 33 percent of the share) and market economy countries (about 67 percent) will exceed 12 trillion USD. The world population is growing and aging. The number of health-care professionals is not in step with future population needs. Health-care facilities are expected to help improve health outcomes. Preventable errors are costly, especially in human suffering, and should be addressed expediently. Many health-care providers have already adopted patient safety safeguards and standards. Many safety practices are simple and should be adopted as soon as possible. Increasing the number of providers, reducing working hours and fatigue, improving communications, providing systems for blame-free reporting, and engaging patients in understanding the health safety culture should be priorities.