This study investigated employees’ innovative performance in a highly competitive and rapidly changing workplace. Specifically, employees’ innovative performance is correlated to the Big Five personality and innovative culture through the mediation effect of psychological safety in the Chinese manufacturing industry. Time-lagged data were collected from 285 employees and analysed on both SmartPLS and SPSS software. Resultantly, the innovative culture and the Big Five personality of extraversion, agreeableness, neuroticism, conscientiousness, and openness individually impacted employees’ innovative performance. Furthermore, psychological safety significantly mediated the relationships between agreeableness and innovative performance, between neuroticism and innovative performance, and between openness and innovative performance. Organisations should consider employees’ personalities when fostering workplace creativity and adjusting training and development. Recognising employees’ personality types may also assist employees in unique performance, fulfilling career goals, and uncovering growth potential.