Working Memory Load Condition Research Articles

Age differences in the recruitment of syntactic analysis and semantic plausibility during sentence comprehension

Syntactic analysis and semantic plausibility provide important cues to build the meaningful representation of sentences. The purpose of this research is to explore the age-related differences in the use of syntactic analysis and semantic plausibility during sentence comprehension under different working memory load conditions. A sentence judgment task was implemented among a group of older and younger adults. Semantic plausibility (plausible, implausible) and syntactic consistency (consistent, inconsistent) were manipulated in the experimental stimuli, and working memory load (high, low) was varied by manipulating the presentation of the stimuli. The study revealed a stronger effect of semantic plausibility in older adults than in younger adults when working memory load was low. But no significant age difference in the effect of syntactic consistency was discovered. When working memory load was high, there was a stronger effect of semantic plausibility and a weaker effect of syntactic consistency in older adults than in younger adults, which suggests that older adults relied more on semantic plausibility and less on syntactic analysis than younger adults. The findings indicate that there is an age-related increase in the use of semantic plausibility, and a reduction in the use of syntactic analysis as working memory load increases.

The impact of different distractions on outdoor visual search and object memory

We investigated whether and how different types of search distractions affect visual search behavior and target memory while participants searched in a real-world environment. They searched either undistracted (control condition), listened to a podcast (auditory distraction), counted down aloud at intervals of three while searching (executive working memory load), or were forced to stop the search on half of the trials (time pressure). In line with findings from laboratory settings, participants searched longer but made fewer errors when the target was absent than when it was present, regardless of distraction condition. Furthermore, compared to the auditory distraction condition, the executive working memory load led to higher error rates (but not longer search times). In a surprise memory test after the end of the search tasks, recognition was better for previously present targets than for absent targets. Again, this was regardless of the previous distraction condition, although significantly fewer targets were remembered by the participants in the executive working memory load condition than by those in the control condition. The findings suggest that executive working memory load, but likely not auditory distraction and time pressure affected visual search performance and target memory in a real-world environment.

The Role of Explicit Memory Across Second Language Syntactic Development: A Structural Priming Study

AbstractWe tested whether second language (L2) learners rely more on explicit memory during structural priming at lower than at higher proficiency levels (Hartsuiker & Bernolet, 2017). We compared within‐L2 priming with lexical overlap in 100 low and 100 high proficiency French L2 speakers under low versus high working memory load conditions induced with a letter series recall task presented between primes and targets. The high load condition would prevent explicit recall of primes during target production. Both groups primed more under low than high load. The effect of load was similar across groups, but exploratory analyses with proficiency as a continuous variable suggested that, with increasing proficiency, participants primed less under high load. We discuss how these findings support the idea that learners exploit explicit memory more during priming in early versus later stages of acquisition. Overall, this study showed that explicit memory influences syntactic processing across the L2 learning trajectory.

An experimental and simulation study of the impact of emotional information on analogical reasoning

We investigated whether and how emotional information would affect analogical reasoning. We hypothesized that task-irrelevant emotional information would impair performance whereas task-relevant emotional information would enhance it. In Study 1, 233 undergraduates completed a novel version of the People Pieces Task (Emotional Faces People Task), an analogical reasoning task in which the task characters displayed emotional or neutral facial expressions (within-participants). The emotional faces were relevant or irrelevant to the task (between-participants). We simulated the behavioral results using the Learning and Inference with Schemas and Analogies (LISA) model of relational reasoning. LISA is a neurally plausible, symbolic-connectionist computational model of analogical reasoning. In comparison to neutral trials, participants were slower but more accurate on emotion-relevant trials, and were faster but less accurate on emotion-irrelevant trials. Simulations using the LISA model demonstrated that it is possible to account for the effects of emotional information on reasoning in terms of how emotional stimuli attract attention during a reasoning task. In Study 2, 255 undergraduates completed the Emotional Faces People Task at either a high- or low-working memory load. The high working memory load condition of Study 2 replicated the findings of Study 1, showing that participants were more accurate on emotion-relevant trials than on emotion-irrelevant trials; in Study 2, this increased accuracy could not be accounted for by a speed-accuracy tradeoff. The working memory manipulation influenced the manner in which the congruence (with the correct answer) of emotion-irrelevant emotion influenced performance. Simulations using the LISA model showed that manipulating the salience of emotion, the error penalty, as well as vigilance (which determines the likelihood that LISA will notice it has attended to an irrelevant relation), could reasonably reproduce the behavioral results of both low and high working memory load conditions of Study 2.

Working memory load modulates the processing of audiovisual distractors: A behavioral and event-related potentials study.

The interplay between different modalities can help to perceive stimuli more effectively. However, very few studies have focused on how multisensory distractors affect task performance. By adopting behavioral and event-related potentials (ERPs) techniques, the present study examined whether multisensory audiovisual distractors could attract attention more effectively than unisensory distractors. Moreover, we explored whether such a process was modulated by working memory load. Across three experiments, n-back tasks (1-back and 2-back) were adopted with peripheral auditory, visual, or audiovisual distractors. Visual and auditory distractors were white discs and pure tones (Experiments 1 and 2), pictures and sounds of animals (Experiment 3), respectively. Behavioral results in Experiment 1 showed a significant interference effect under high working memory load but not under low load condition. The responses to central letters with audiovisual distractors were significantly slower than those to letters without distractors, while no significant difference was found between unisensory distractor and without distractor conditions. Similarly, ERP results in Experiments 2 and 3 showed that there existed an integration only under high load condition. That is, an early integration for simple audiovisual distractors (240-340 ms) and a late integration for complex audiovisual distractors (440-600 ms). These findings suggest that multisensory distractors can be integrated and effectively attract attention away from the main task, i.e., interference effect. Moreover, this effect is pronounced only under high working memory load condition.

Visual processing of food stimuli: The impact of working memory load and color.

Our environment is surrounded by appetizing food stimuli that contribute to an increase in health problems such as obesity and overweight. Understanding the cognitive factors underlying the processing of food stimuli can play an important role in health interventions. Recent studies showed that high-calorie food stimuli impair working memory (WM) task performance, and some individuals, such as restrained eaters, are more susceptible to this WM performance decrement. The present study investigated the effect of low and high WM load on the processing of food stimuli in restrained and unrestrained eaters. Using an n-back task, identical food (low and high calorie) and non-food (object) stimuli were presented in colored (Experiment 1A) or in grayscale (Experiment 1B) versions. Performance was assessed by reaction time (RT), d-prime, and response bias C variables. Results revealed differences in the different WM load conditions. While no effects were observed in the low load, higher WM load impaired task performance. Processing the food stimuli, compared to objects, led to longer RTs and decreased task performance, indicated by d prime and response bias, only when the stimuli were presented in color but not in grayscale. Though no difference was observed in restrained and unrestrained eaters, the role of WM load on the visual processing of the food stimuli remains to be further examined.

Neural resources shift under Methylphenidate: A computational approach to examine anxiety-cognition interplay

The reciprocal interplay between anxiety and cognition is well documented. Anxiety negatively impacts cognition, while cognitive engagement can down-regulate anxiety. The brain mechanisms and dynamics underlying such interplay are not fully understood. To study this question, we experimentally and orthogonally manipulated anxiety (using a threat of shock paradigm) and cognition (using methylphenidate; MPH). The effects of these manipulations on the brain and behavior were evaluated in 50 healthy participants (25 MPH, 25 placebo), using an n-back working memory fMRI task (with low and high load conditions). Behaviorally, improved response accuracy was observed as a main effect of the drug across all conditions. We employed two approaches to understand the neural mechanisms underlying MPH-based cognitive enhancement in safe and threat conditions. First, we performed a hypothesis-driven computational analysis using a mathematical framework to examine how MPH putatively affects cognitive enhancement in the face of induced anxiety across two levels of cognitive load. Second, we performed an exploratory data analysis using Topological Data Analysis (TDA)-based Mapper to examine changes in spatiotemporal brain activity across the entire cortex. Both approaches provided converging evidence that MPH facilitated greater differential engagement of neural resources (brain activity) across low and high working memory load conditions. Furthermore, load-based differential management of neural resources reflects enhanced efficiency that is most powerful during higher load and induced anxiety conditions. Overall, our results provide novel insights regarding brain mechanisms that facilitate cognitive enhancement under MPH and, in future research, may be used to help mitigate anxiety-related cognitive underperformance.

Working Memory Load Impact on Effective Connectivity: a Dynamic Causal Modeling Study

This study aims to examine the roles of the brain regions in working memory (WM) processing and the modulatory effects of WM load. Electroencephalogram (EEG) signals were recorded when participants perform a letter-version n-back task with three different levels of WM load. The directional causal connections between brain regions were estimated using Dynamic Causal Modeling (DCM). The directions and strengths of the connections were compared for different WM load conditions. The results showed a right-lateralized, backward-only connection pattern for the high WM load condition. The results also showed changes in the roles of the brain regions when the WM load increases. These findings of the modulatory effects of WM load may be utilized in measuring cognitive states, and designing adaptive automation in augmented cognition programs.

Adolescent-specific memory effects: evidence from working memory, immediate and long-term recognition memory performance in 8-30 yr olds.

Working memory and recognition memory develop across adolescence, but the relationship between them is not fully understood. We investigated associations between n-back task performance and subsequent recognition memory in a community sample (8-30 yr, n = 150) using tasks from the Adolescent Brain Cognitive Development Study (ABCD Study) to cross-sectionally assess memory in an age range that will be sampled longitudinally. We added a 24-h delay condition to assess long-term recognition. Overall working memory, immediate and long-term recognition performance peaked in adolescence. Age effects in recognition memory varied by items (old targets, old distractors, and new items) and delay (0 and 24 h). For immediate recognition, accuracy was higher for targets and new items than for distractors, with accuracy for targets peaking in adulthood and accuracy for new items peaking during adolescence. For long-term recognition, adolescents' accuracy was higher for targets than distractors, while adults showed similarly high accuracy for targets and distractors and children showed low accuracy for both. This pattern appeared to be specific to recognition of items from the high working memory load condition. The results suggest that working memory may facilitate long-term recognition of task-relevant over irrelevant items and may benefit the detection of new information during adolescence.

Music, Math, and Working Memory: Magnetoencephalography Mapping of Brain Activation in Musicians.

Musical transposing is highly demanding of working memory, as it involves mentally converting notes from one musical key (i.e., pitch scale) to another key for singing or instrumental performance. Because musical transposing involves mental adjustment of notes up or down by a specific amount, it may share cognitive elements with arithmetical operations of addition and subtraction. We compared brain activity during high and low working memory load conditions of musical transposing versus math calculations in classically trained musicians. Magnetoencephalography (MEG) was sensitive to differences of task and working memory load. Frontal-occipital connections were highly active during transposing, but not during math calculations. Right motor and premotor regions were highly active in the more difficult condition of the transposing task. Multiple frontal lobe regions were highly active across tasks, including the left medial frontal area during both transposing and calculation tasks but the right medial frontal area only during calculations. In the more difficult calculation condition, right temporal regions were highly active. In coherence analyses and neural synchrony analyses, several similarities were seen across calculation tasks; however, latency analyses were sensitive to differences in task complexity across the calculation tasks due to the high temporal resolution of MEG. MEG can be used to examine musical cognition and the neural consequences of music training. Further systematic study of brain activity during high versus low memory load conditions of music and other cognitive tasks is needed to illuminate the neural bases of enhanced working memory ability in musicians as compared to non-musicians.

The effect of working memory load on feedback processing: Evidence from an event-related potentials (ERP) study

<p id=C2>Feedback processing plays an important role in behavior modification and knowledge acquisition. Previous research has explored the neurophysiological basis and psychological functions of feedback processing and proposed corresponding theoretical models, but little is known about how working memory (WM) load affects feedback processing. Studies have reported electrophysiological indicators, such as the reward positivity (RewP) and the related theta and delta oscillations, the P3 and the late positive potential (LPP), during brain processing feedback. This study will further examine how WM load modulates these electrophysiological components and their corresponding cognitive functions. <break/>In the present study, we used a dual-task paradigm to investigate feedback processing under different WM load conditions. This study included 25 healthy college students and used a 3 (WM load: baseline vs. low WM load vs. high WM load) by 2 (feedback valence: positive vs. negative) within-participant factorial design. During the experiment, participants were asked to perform a simple gambling task and a spatial memory task simultaneously, and the magnitude of the WM load included three conditions: baseline, low WM load and high WM load. The RewP generated in the early stage of feedback processing and the LPP generated in the late stage of feedback processing, as well as the delta and theta oscillations related to feedback evaluation, were analyzed. <break/>The behavioral results showed that the accuracy of the low WM load condition was significantly higher than that of the high WM load condition. The electrophysiological results showed that the amplitudes of the RewP were sensitive to feedback valence, with positive feedback evoking larger RewP than negative feedback, but the RewP was not affected by the WM load. There was no difference in the P3 amplitude under the different WM load conditions. For the LPP, there was a significant interaction between the WM load and feedback valence. Further analysis revealed that, in the high WM load condition, the LPP amplitude was larger for positive feedback than for negative feedback. The theta power differences between negative feedback and positive feedback were larger in the low WM load condition than in the high WM load condition. For delta oscillation, the power was increased after positive feedback compared to after negative feedback, but there was no difference at different WM load levels. <break/>The RewP results indicate that the participants process feedback valence information well under all three WM load conditions in the experiment. The LPP results suggest that the participants assigned additional emotional motivation to the feedback outcome as a result of their cognitive efforts under high WM load conditions. The ERP results for the time domain dimension showed that the effect of the WM load on feedback processing was most noticeable in the later stages of feedback processing. Moreover, these observations support the argument that the RewP and theta power reflect distinct cognitive phenomena; namely, the RewP reflects the processing of feedback valence in the anterior cingulate cortex (ACC), whereas theta oscillations reflect the role of the ACC in cognitive control. The WM load selectively modulates the cognitive control process in the ACC.

Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls

Alterations in frontal and parietal neural activations during working memory task performance have been suggested as a candidate endophenotype of obsessive-compulsive disorder (OCD) in studies involving first-degree relatives. However, the direct link between genetic risk for OCD and neuro-functional alterations during working memory performance has not been investigated to date. Thus, the aim of the current functional magnetic resonance imaging (fMRI) study was to test the direct association between polygenic risk for OCD and neural activity during the performance of a numeric n-back task with four working memory load conditions in 128 participants, including patients with OCD, unaffected first-degree relatives of OCD patients, and healthy controls. Behavioral results show a significant performance deficit at high working memory load in both patients with OCD and first-degree relatives (p < 0.05). A whole-brain analysis of the fMRI data indicated decreased neural activity in bilateral inferior parietal lobule and dorsolateral prefrontal cortex in both patients and relatives. Most importantly, OCD polygenic risk scores predicted neural activity in orbitofrontal cortex. Results indicate that genetic risk for OCD can partly explain alterations in brain response during working memory performance, supporting the notion of a neuro-functional endophenotype for OCD.

Bored, distracted, and forgetful: The impact of mind wandering and boredom on memory encoding.

Mind wandering, defined as focusing attention towards task-unrelated thoughts, is a common mental state known to impair memory encoding. This phenomenon is closely linked to boredom. Very few studies, however, have tested the potential impact of boredom on memory encoding. Thus, the present study aimed at manipulating mind wandering and boredom during an incidental memory encoding task, to test their differential impact on memory encoding. Thirty-two participants performed a variant of the n-back task in which they had to indicate if the current on-screen object was the same as the previous one (1-back; low working memory load) or the one presented three trials before (3-back; high working memory load). Moreover, thought probes assessing either mind wandering or boredom were randomly presented. Afterwards, a surprise recognition task was delivered. Results showed that mind wandering and boredom were highly correlated, and both decreased in the high working memory load condition, while memory performance increased. Although both boredom and mind wandering predicted memory performance taken separately, we found that mind wandering was the only reliable predictor of memory performance when controlling for boredom and working memory load. Model comparisons also revealed that a model with boredom only was outperformed by a model with mind wandering only and a model with both mind wandering and boredom, suggesting that the predictive contribution of boredom in the complete model is minimal. The present results confirm the high correlation between mind wandering and boredom and suggest that the hindering effect of boredom on memory is subordinate to the effect of mind wandering.

Effect of Working Memory Load and Typicality on Semantic Processing in Aphasia.

This study evaluated the effects of a linguistic characteristic, typicality, and a processing variable, working memory on the abilities of people with aphasia (PWA) and neurologically intact adults to process semantic representations. This was accomplished using a newly developed assessment task, the Category Typicality Test, which was created for the Temple Assessment of Language and Short-Term Memory in Aphasia. A post hoc quasi-experimental design was used. Participants included 27 PWA and 14 neurologically intact adults who completed the picture and word versions of the Category Typicality Test, which required them to determine if two items are in the same category. Memory load was altered by increasing the number of items to be compared, and the typicality of items was altered to increase linguistic complexity. A four-way mixed analysis of covariance was conducted. There was a significant interaction between working memory load and category typicality with performance accuracy decreasing as working memory load increased and category typicality decreased. There was also a significant interaction for typicality and stimuli with better performance in the picture condition and a significant interaction for working memory and group with lower performance accuracy for PWA. Post hoc pairwise comparisons revealed differences between memory load, typicality, stimuli conditions, and group. PWA also showed greater magnitude of change than neurologically intact adults when comparing high and low working memory load conditions, but not typicality conditions. Increasing working memory load had the most substantial impact on the accuracy of category judgments in PWA, but the interaction between increased working memory load and decreased category typicality of items to be compared resulted in reduced accuracy in both groups. These findings suggest that manipulation of processing and linguistic variables in assessment will provide insight into the nature of linguistic breakdown in aphasia. Supplemental Material https://doi.org/10.23641/asha.14781996.

Working memory load modulates oscillatory activity and the distribution of fast frequencies across frontal theta phase during working memory maintenance

Working memory (WM) is a keystone of our cognitive abilities. Increasing load has been shown to dampen its performance and affect oscillatory neural activity in different frequency bands. Nevertheless, mixed results regarding fast frequencies activity and a lack of research on WM load modulations of cross-frequency phase-amplitude coupling mechanisms preclude a better understanding of the impact of increased WM load levels on brain activity as well as inter-regional communication and coordination supporting WM processes. Hence, we analyzed the EEG activity of 25 participants while performing a delayed-matching-to-sample (DMS) WM task with three WM load levels. Current density power and distribution at the source level for theta, beta, and gamma frequencies during the task's delay period were compared for each pair of WM load conditions. Results showed maximal increases of theta activity in frontal areas and of fast frequencies' activity in posterior regions with WM load, showing the involvement of frontal theta activity in WM maintenance and the control of attentional resources and visual processing by beta and gamma activity. To study whether WM load modulates communication between cortical areas, posterior beta and gamma amplitudes distribution across frontal theta phase was also analysed for those areas showing the largest significant WM load modulations. Higher beta activity amplitude at bilateral cuneus and right middle occipital gyrus, and higher gamma activity amplitude at bilateral posterior cingulate were observed during frontal theta phase peak in low than high memory load conditions. Moreover, greater fast beta amplitude at the right postcentral gyrus was observed during theta phase trough at right middle frontal gyrus in high than low memory load conditions. These results show that WM load modulates whether interregional communication occurs during theoretically optimal or non-optimal time windows, depending on the demands of frontal control of posterior areas required to perform the task successfully.

Disgust face captures more attention in individuals with high social anxiety when cognitive resources are abundant: Evidence from N2pc

There is a debate about the relative contributions of top-down and bottom-up attention to the threat-related attentional bias. In this study we investigated the attentional bias in individuals with social anxiety under conditions of no, low and high visual working memory (WM) load. Event-related potential (ERP) and response time (RT) data were recorded while participants performed the dot-probe task and a concurrent change-detection task. The ERP results revealed that the maximum N2pc effect emerged in no visual WM load condition in individuals with social anxiety. The difference of N2pc effect between high socially anxious (HSA) and low socially anxious (LSA) groups was observed in no visual WM load condition, whereas this difference was eliminated under low and high load conditions. However, no significant main effects or interactions were observed in the behavioral index (reflected by Trial Level-Bias Score variability). Overall, the findings indicate the critical role of top-down attention on social anxiety-related attentional bias, which have important implication for attentional bias modification.

Predicting Stimulus Modality and Working Memory Load During Visual- and Audiovisual-Acquired Equivalence Learning.

Scholars have extensively studied the electroencephalography (EEG) correlates of associative working memory (WM) load. However, the effect of stimulus modality on EEG patterns within this process is less understood. To fill this research gap, the present study re-analyzed EEG datasets recorded during visual and audiovisual equivalence learning tasks from earlier studies. The number of associations required to be maintained (WM load) in WM was increased using the staircase method during the acquisition phase of the tasks. The support vector machine algorithm was employed to predict WM load and stimulus modality using the power, phase connectivity, and cross-frequency coupling (CFC) values obtained during time segments with different WM loads in the visual and audiovisual tasks. A high accuracy (>90%) in predicting stimulus modality based on power spectral density and from the theta–beta CFC was observed. However, accuracy in predicting WM load was higher (≥75% accuracy) than that in predicting stimulus modality (which was at chance level) using theta and alpha phase connectivity. Under low WM load conditions, this connectivity was highest between the frontal and parieto-occipital channels. The results validated our findings from earlier studies that dissociated stimulus modality based on power-spectra and CFC during equivalence learning. Furthermore, the results emphasized the importance of alpha and theta frontoparietal connectivity in WM load.

High working memory load impairs selective attention: EEG signatures.

According to the load theory of attention, increased working memory load impairs selective attention, resulting in greater distractor interference during inhibitory control processing. However, the EEG signatures correlated with this modulation effect of working memory on inhibitory control remain unclear. In present study, 25 healthy human participants performed a flanker task in a low and high working memory load conditions, while behavioral and electroencephalography (EEG) data were recorded. The results showed a larger reaction time interference effect while increasing working memory load, and this was accompanied by a larger N2 amplitude and a smaller P3 amplitude for incongruent trials. Time-frequency analysis revealed that, increased working memory load had no significant modulation effect on flanker related theta-ERS magnitude. Incongruent trials evoked smaller alpha-ERD magnitude than congruent trials in both low and high working memory load conditions. Increased working memory load was associated with larger flanker related alpha-ERD magnitude. Taken together, these results suggested that increased working memory load can impair top-down cognitive control processes, impairing inhibitory control processes during performance of the flanker task.

Working Memory Load Selectively Influences Response Inhibition in a Stop Signal Task.

Inhibitory control is a key executive function and has been studied extensively using the stop signal task. By applying a simple race model that posits an independent race between a GO process responsible for initiation of responses and a STOP process responsible for inhibition of responses, one can estimate how long it takes an individual to inhibit an ongoing response, the stop signal reaction time. Here, we examined how stop signal reaction time can be affected by working memory. Participants engaged in a dual task; they completed a stop signal task under low and high working memory load conditions. Working memory capacity was also measured. We found that the STOP process was lengthened in the high, compared to the low, working memory load condition, as evidenced by differences in stop signal reaction time. The GO process was unaffected and working memory capacity could not account for differences across the load conditions. These results indicate that inhibitory control can be influenced by placing demands on working memory.

Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study

Anhedonia, a core symptom of Major Depressive Disorder (MDD), manifests as a lack or loss of motivation as reflected by decreased reward responsiveness, at both behavioral and neural (i.e., striatum) levels. Exposure to stressful life events is another important risk factor for MDD. However, the mechanisms linking reward-deficit and stress to MDD remain poorly understood. Here, we explore whether the effects of stress exposure on reward processing might differentiate between Healthy Vulnerable adults (HVul, i.e., positive familial MDD) from Healthy Controls (HCon). Furthermore, the well-described reduction in cognitive resources in MDD might facilitate the stress-induced decrease in reward responsiveness in HVul individuals. Accordingly, this study includes a manipulation of cognitive resources to address the latter possibility. 16 HVul (12 females) and 16 gender- and age-matched HCon completed an fMRI study, during which they performed a working memory reward task. Three factors were manipulated: reward (reward, no-reward), cognitive resources (working memory at low and high load), and stress level (no-shock, unpredictable threat-of-shock). Only the reward anticipation phase was analyzed. Imaging analyses focused on striatal function. Compared to HCon, HVul showed lower activation in the caudate nucleus across all conditions. The HVul group also exhibited lower stress-related activation in the nucleus accumbens, but only in the low working memory (WM) load condition. Moreover, while stress potentiated putamen reactivity to reward cues in HVul when the task was more demanding (high WM load), stress blunted putamen reactivity in both groups when no reward was at stake. Findings suggest that HVul might be at increased risk of developing anhedonic symptoms due to weaker encoding of reward value, higher difficulty to engage in goal-oriented behaviors and increased sensitivity to negative feedback, particularly in stressful contexts. These findings open new avenues for a better understanding of the mechanisms underlying how the complex interaction between the systems of stress and reward responsiveness contribute to the vulnerability to MDD, and how cognitive resources might modulate this interaction.