In the post-COVID-19 era, world’s demand in caregiving increases dramatically. In such a highly challenging work circumstance, caregivers are more likely to have emotional exhaustion than many other service providers. Past research mostly focused on off-the-job recovery strategies and neglected on-the-job recovery strategies. Drawing on conservation of resources theory, we hypothesize that caregivers’ compassion towards clients will cause them emotional exhaustion which in turn hurts their subjective personal accomplishment and well-being. Moreover, our research investigates on-the-job recovery by uncovering the moderating role of client interaction (client reciprocity) and co-worker interaction (experienced compassion from co-workers) to buffer from emotional exhaustion. Results from a two-wave field study in a large-scale hospital of China support most of our hypotheses. Theoretical and practical implications are discussed.