Background: Social support and quality of life (QoL) are crucial for the well-being of individuals. Myanmar women migrant workers in Thailand represent a vulnerable population, yet there are limited studies on social support and QoL among these migrants. Methods: This cross-sectional study investigated associations between social support and QoL among Myanmar women migrant workers in central and northern Thailandthrough multistage sampling using a structured questionnaire. Social support was measured using the Medical Outcome Study Social Support Survey, and QoL was assessed using the WHOQOL-BREF. Multiple linear regression was analysed to find the association between social support and QoL, adjusting for sociodemographic variables. Results: Among 575 participants, they had an average overall social support score of 61.73 ± 16.47, with low support = 24.35%, moderate support = 46.43%, and high support = 29.22%. The average overall QoL score was 90.54 ± 13.23. Higher social support was positively associated with QoL (B = 4.781 for moderate support and B = 9.721 for high support, p < 0.01). Higher education and easier access to emergency finances were also positively associated with QoL. Conclusion: Tailored social support interventions are recommended to enhance QoL among Myanmar women migrant workers in Thailand. Community nurses play a critical role in these interventions by providing education, facilitating access to resources, and fostering supportive networks.