The nutrition security of women is critically important for society’s well-being. Therefore, this study was conducted to determine the determinants of the nutrition security status of rural women in Northwest Ethiopia. Data collected from rural women in 197 randomly selected households were analyzed using a binary logit regression model. The results show that 72.6% of the women are nutritionally insecure. The determinants that significantly affect nutrition security status are family size (a negative effect), women’s daily feed frequency, milk consumption, feeding habits of fruits and vegetables, feeding habits of animal products, and women empowerment (all positive effects). The weight, height, and BMI of nutritionally insecure women were significantly lower than those of nutritionally secure women. These findings reveal the need for government and other stakeholders’ interventions to increase access to nutritious food products and to provide training on feeding culture and dietary diversity to women. The findings of this study can help the Government of Ethiopia to focus on the significant determinants to achieve its National Development Priorities focusing on the Sustainable Development Goals (SDGs) of the UN, particularly Goals 2, 3, and 5.