The Internet of Things (IoT) has emerged as a disruptive force, transforming industries, cities, and daily life in a time of unprecedented connection. This outcome has called for robust security, reliability, and efficient power management for the IoT network. The security of small mobile devices within the IoT network has become a pressing concern due to the multitude of wireless vulnerabilities that threaten data transmission, the harsh wireless environment for data transmission, and the need for low-power consumption devices. This study proposed the development of a new parallel-pipelined-memory (P2M) Blowfish field programmable gate array (FPGA)-based radio system as a prototype of a secured mobile device for IoT application. The FPGA platform verified the proposed system, indicating a minimum of 64 % power-throughput improvement. In this case, the hardware utilisation was reduced by 3.5 % compared to the recently published works. Meanwhile, the real-time transmission analysis of the suggested P2M Blowfish radio system in a non-line-of-sight (NLOS) indoor environment indicated that the transmitted data over 2.4 GHz ZigBee standard at 10 dBm radio frequency (RF) power level demonstrated the optimum signal quality with received signal strength and signal-to-noise ratio (SNR) of −34.58 dBm and 39.06 dB, respectively. This feature also included a 6.25 × 10−3 minimum bit error rate (BER) at 61 m as the maximum communication range. Thus, the P2M Blowfish FPGA-based radio system could improve the security, reliability, and power efficiency of IoT networks.