The Yellow River, China’s second-largest river, is renowned for its high sediment content. In response to the potential impacts of climate change on Yellow River water resources and water environmental management, an advanced monitoring and forecasting system for water and sediment throughout the entire Yellow River basin—from its source to the sea—is urgently needed. In this paper, based on the current status of water and sediment monitoring technologies, we proposed an integrated remote sensing monitoring network that combines satellite remote sensing, drone remote sensing, and ground-based wireless automatic monitoring networks, aiming to achieve the digital monitoring of water and sediment across the entire Yellow River basin, from its upper reaches to its estuary in the Bohai Sea. By utilizing ground-based in situ hyperspectral stations for sediment source areas in the upper reaches, such as the Qingshui River basin in Ningxia, and satellite remote sensing for midstream processes in the Xiaolangdi reservoir before the flood season in 2023, as well as downstream monitoring at the Yellow River estuary, this paper demonstrates the novelty and efficiency of the space–air–ground integrated remote sensing monitoring technology.