Drug delivery systems (DDS) are developed for the controlled delivery of therapeutic agents. After administration, the DDS releases the active agents, and subsequently, the bioactive molecules are transported across various biological barriers to reach the site of action. Scientists have made a major contribution in understanding the role of various physiological obstacles for the efficient delivery of drugs in the circulatory system and the diffusion of drugs across cells and tissues. This review discusses and compares the drug delivery methods, drug delivery techniques, telemetry drug delivery, mechanical structure of the drug delivery system, and multiple syringes for DDS and also nano-technology drug delivery. The review leads to the conclusion that the wireless drug delivery method overcomes almost all of the drawbacks of the other methods and thus deserves the most attention in future biomedical research.