Ensuring blast protection for existing buildings, especially addressing the vulnerability of conventional windows, is a significant challenge. Such unprotected windows can shatter even with moderate blast loads, posing a substantial risk of injury to occupants. This article discusses experimental research on enhancing the blast protection of single casement windows with insulating glass units and frames made of unplasticized polyvinyl chloride (uPVC). A retrofit concept using anti-shatter films, metallic sash reinforcements, adhesive bonding of the glazing to the sash frame, and a burglary resistance fitting-system was developed and tested in an explosion-driven shock-tube. Moreover, novel patches made of glass fiber-reinforced polymer applied to the corners of the window frames have been tested and proven effective in providing additional strength to the window. The study concludes that the tested combination of retrofit measures can significantly reduce hazards from window fragments without compromising functionality or aesthetics.