Refuge floors in high-rise buildings ensure a haven for occupants to stay in an emergencyprimarily during a fire breakout. Provisions for natural ventilation of the refuge floor are mandatory in all fire codes as they help release smoke and heat build-up. However, the effectiveness of such provisions has been questioned in many studies. This research employs large eddy simulations based three-dimensional computational fluid dynamics modelling on a real-world high-rise building to investigate the efficacy of natural ventilation in a refuge floor during a fire. Consequently, the performance was assessed by evaluating the temporal and spatial distributions of temperature, visibility, smoke and carbon monoxide concentration. Emphasis was placed on determining the adequacy of window placement and openings. Analysis was started with a code-compliant window configuration. Subsequently the window size and the layout were iteratively modified using simulation results. Seasonal wind variations were also considered. Results showed that a well-engineered natural ventilation strategy can considerably improve the refuge floor habitability. Simulations also revealed limitations of natural ventilation under certain wind conditions, necessitating a backup mechanical system. This also underlined that combining fire analysis with cutting-edge modelling allows tailored natural ventilation for refuge floors, maximising safe occupancy during fires.