Event Abstract Back to Event An ERP study about altered visual attentional system in bipolar disorder Toshihiko Maekawa1*, T. Tsunoda1, N. Oribe1, N. Fukushima1, T. Onitsuka1, S. Tobimatsu1 and S. Kanba1 1 Departments of Neuropsychiatry and Clinical Neurophysiology,Kyushu University, Japan BACKGROUND: Bipolar disorder (BP) is one of mental disease which hard to make diagnosis. Cognitive dysfunction of BP may result from abnormal attentional processing in the brain. Attentional processing consists of two stages: One is involuntary attention (automatic) processing and the other is voluntary attention processing. The former is assessed by mismatch negativity (MMN) while the latter is evaluated by P300. These ERP components may be useful to discriminate a patient with BP from healthy person. The aim of this study was to clarify abnormality of visual attention system in BP by measuring P300 and visual MMN (vMMN). METHODS Eleven patients with BP were seated in front of a 20-inch monitor in the dark room comfortably. They were instructed to attend to a story through earphones binaurally and to also pay attention to a visual target which was presented on a monitor. Black-white circular windmill patterns consisting of a standard, a deviant, and a target stimulus whose ratios were 8:1:1 were presented on the monitor randomly. The difference in the three stimuli was the number of vanes. EEG was recorded by 128-ch high dense array equipment throughout the experiment continuously. VMMN was obtained by subtracting ERPs to deviant stimulus from that to standard stimulus. P300 was recorded by the response of target stimulus. RESULTS Data of nine patients with BP were analyzed. There was not statistical difference in behavior performance (accuracy of questionnaire about the context of heard story and accuracy and response time of target detection) between BP and normal control (NC) group. Responses of all of the participants were obtained P300 and vMMN. P300 in BP was delayed than that of NC. Mean amplitude of vMMN in BP was significantly smaller than that of NC, and latency of vMMN of the patients was prolonged from that of NC. CONCLUSIONS Our results suggest that there exists abnormal visual attentional processing in BP. P300 and vMMN are more sensitive to detect it than behavior performance index. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Workshop 1: Visual Mismatch Negativity (vMMN) Citation: Maekawa T, Tsunoda T, Oribe N, Fukushima N, Onitsuka T, Tobimatsu S and Kanba S (2009). An ERP study about altered visual attentional system in bipolar disorder. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.030 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Mar 2009; Published Online: 20 Mar 2009. * Correspondence: Toshihiko Maekawa, Departments of Neuropsychiatry and Clinical Neurophysiology,Kyushu University, Fukuoka, Japan, hiko.maekawa@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Toshihiko Maekawa T. Tsunoda N. Oribe N. Fukushima T. Onitsuka S. Tobimatsu S. Kanba Google Toshihiko Maekawa T. Tsunoda N. Oribe N. Fukushima T. Onitsuka S. Tobimatsu S. Kanba Google Scholar Toshihiko Maekawa T. Tsunoda N. Oribe N. Fukushima T. Onitsuka S. Tobimatsu S. Kanba PubMed Toshihiko Maekawa T. Tsunoda N. Oribe N. Fukushima T. Onitsuka S. Tobimatsu S. Kanba Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.