The Gulf Stream, a major ocean current in the North Atlantic ocean is a key component in the global redistribution of heat and is important for marine ecosystems. Based on 27 years (1993–2019) of wind reanalysis and satellite altimetry measurements, we present observational evidence that the path of this freely meandering jet after its separation from the continental slope at Cape Hatteras, aligns with the region of maximum cyclonic vorticity of the wind stress field known as the positive vorticity pool. This synchronicity between the wind stress curl maximum region and the Gulf Stream path is observed at multiple time-scales ranging from months to decades, spanning a distance of 1500 km between 70 and 55W. The wind stress curl in the positive vorticity pool is estimated to drive persistent upward vertical velocities ranging from 5 to 17 cm day−1 over its ~ 400,000 km2 area; this upwelling may supply a steady source of deep nutrients to the Slope Sea region, and can explain as much as a quarter of estimated primary productivity there.