The fatigue damage and power generation of wind farms (WFs) is related to their service lifetime and economic benefits. In this paper, an asynchronous distributed optimal wake control (OWC) scheme is proposed to suppress fatigue load and increase power extraction in doubly-fed induction generator (DFIG)-based wind farm (WF). To improve control flexibility, the generator torque and pitch angle of a wind turbine (WT) is simultaneously controlled. Then, considering the influence of wake effect, the wind speed sensitivity is used to combine with the states of WTs for formulating the model predictive control (MPC)-based optimal control objectives. To deal with the higher computational complexity of the aerodynamic interactions efficiently, an asynchronous distributed alternating direction method of multipliers (AD-ADMM) is designed for the control system. A layout of a 3 × 5 wake WF is considered in the case studies to validate the outstanding performance of the proposed scheme.