Wider Impact Research Articles

BLESSED MARCELINA DAROWSKA – A NOTABLE EXAMPLE OF POLISH MYSTICISM OF THE 19TH CENTURY

Blessed Marcelina Darowska (1827–1911), founder of the Congregation of the Sisters of the Immaculate Conception, stands out from the numerous Polish mystics of the 19th century primarily because of her rich experience of mystical life and the original theory of mysticism (mystology) contained in her writings. She left a two-volume ascetic-mystical treatise, spiritual notes (“Diary”), many letters to spiritual directors and some sisters, as well as texts of retreats that she preached to students and various people. She created her own mystical language.As an outstanding representative of 19th-century Polish mysticism, she stands out from other trends in mystical life, including: healthy patriotism, Marian piety with particular emphasis on the title of Mary Queen of Poland, apostolate in the education of girls and women, and the development of various forms of folk piety that strengthen National identity.It had a wide impact on Polish, Belarusian and Ukrainian society, mainly through educational institutions for girls. She also maintained active contacts, including: with Saint archbishop Józef Bilczewski, Saint archbishop Szczęsny Feliński and other outstanding personalities of the spiritual and social life of those times.

Poverty Analysis of Children's Education Level in Paokmotong Village, Masbagik Sub-District

This study aims to determine the Poverty Analysis of Children's Education Level in Paokmotong Village. This research uses a descriptive type of qualitative approach. The data collection techniques used by researchers are observation, interviews and documentation with 80 respondents to poor people in Paokmotong village. While the data analysis technique used is descriptive analysis technique through qualitative research, which uses data and information obtained directly from information then analyzed using the existing theoretical basis and obtained systematically based on facts in the field. The poverty experienced by the poor in Paokmotng Village has a wide impact on the level of education in the community. This can be seen in various aspects, namely employment or income, human resources, natural resources and government policies. From these various aspects, the impact of poverty is relative because each family has and feels a different impact from other families in the level of education, namely a low level of education

Modeling and understanding the impact of COVID-19 containment policies on mobile service consumption in French cities

Amid recent studies that have been exploring the wide impact that COVID-19 containment policies have had across sectors and industries, we investigate how mobility restrictions enacted in French cities during the later stages of the pandemic have affected the usage of smartphones and mobile applications. Leveraging a large-scale dataset of over 14 billion records, we unveil and quantify the substantial incidence of the different measures enforced in urban France to combat the COVID-19 epidemic on mobile service consumption. We present a simple but effective spatial linear model that can relate changes occurring at fine-grained spatial zoning in both global and per-service traffic to a limited set of socioeconomic indicators. Our model unveils some of the mechanisms that drove the significant evolution of mobile data traffic demands during the pandemic. It allows observing how the demand for mobile services has been affected by COVID-19 in very different ways across urban areas characterized by diverse population density, income levels and leisure area presence. It also discloses that usages of individual smartphone applications have been impacted in highly heterogeneous ways by the pandemic, even more so when considering the composite impacts of different transitions between periods characterized by diverse restrictions. Our results can aid governments in understanding how their measures were received across the space and different portions of population, and network operators to comprehend changes in usage due to extraordinary events, which can be used to optimize service provisioning.

Has the application of sanctions against financial institutions involved in money laundering had a deterrent effect?

Money laundering is one of the crimes that has a wide impact, both economically and socially. With the increasing complexity of global financial networks, financial institutions must be more responsible in preventing money laundering practices. The existence of strong and transparent financial institutions is essential to maintain the integrity of the financial system. Using normative juridical research methods, this study analyzes the regulations that govern sanctions and law enforcement practices. The purpose of this study is to evaluate whether the sanctions applied have provided a deterrent effect to financial institutions that violate the law. The results of the study show that although there are several institutions affected by sanctions, in general, the implementation of sanctions has not been effective in providing a significant deterrent effect. These obstacles arise due to the lack of strict supervision, weak international cooperation, and inconsistencies in law enforcement. In addition, the proactive attitude of financial institutions in fulfilling reporting obligations also needs to be improved. Therefore, reforms in the sanctions system and improved law enforcement mechanisms are needed to create a stronger deterrent effect against financial institutions involved in money laundering

Dynamical transition in controllable quantum neural networks with large depth

Understanding the training dynamics of quantum neural networks is a fundamental task in quantum information science with wide impact in physics, chemistry and machine learning. In this work, we show that the late-time training dynamics of quantum neural networks with a quadratic loss function can be described by the generalized Lotka-Volterra equations, leading to a transcritical bifurcation transition in the dynamics. When the targeted value of loss function crosses the minimum achievable value from above to below, the dynamics evolve from a frozen-kernel dynamics to a frozen-error dynamics, showing a duality between the quantum neural tangent kernel and the total error. In both regions, the convergence towards the fixed point is exponential, while at the critical point becomes polynomial. We provide a non-perturbative analytical theory to explain the transition via a restricted Haar ensemble at late time, when the output state approaches the steady state. Via mapping the Hessian to an effective Hamiltonian, we also identify a linearly vanishing gap at the transition point. Compared with the linear loss function, we show that a quadratic loss function within the frozen-error dynamics enables a speedup in the training convergence. The theory findings are verified experimentally on IBM quantum devices.

Collaboration or competition? The value of sector-wide collaboration in educational technology research

Collaboration or competition? This question is at the centre of this editorial, which explores the importance of sector-wide approaches to research into educational technology. This has become particularly relevant in recent years in response to a range of significant challenges or disruptions the tertiary education sector has had to face, for example, responding to the COVID-19 pandemic or the emergence of new generative AI tools. To address these challenges, we have taken a collaborative approach to writing this editorial, with contributing authors from across the world responding to four key questions. The responses to those questions were then arranged into four key themes: collaboration in response to disruption, individual benefits from collaboration, communal benefits from collaboration, and ensuring collaborative wisdom. The editorial concludes with a section that situates the preceding discussion in a broader context and challenges us to consider our wider impact on the world as a sector and, in particular, as related to educational technology. We conclude that collaboration is a must and has the potential to empower us to push the boundaries of what is possible.

Gene and transcript expression patterns, coupled with isoform switching and long non-coding RNA dynamics in adipose tissue, underlie the longevity of Ames dwarf mice.

Our study investigates gene expression in adipose tissue of Ames dwarf (df/df) mice, whose deficiency in growth hormone is linked to health and extended lifespan. Recognizing adipose tissue influence on metabolism, aging, and related diseases, we aim to understand its contribution to the health and longevity of df/df mice. We have identified gene and transcript expression patterns associated with critical biological functions, including metabolism, stress response, and resistance to cancer. Intriguingly, we identified genes that,despite maintaining unchanged expression levels, switch between different isoforms, impacting essential cellular functions such as tumor suppression, oncogenic activity, ATP transport, and lipid biosynthesis and storage. The isoform switching is associated with changes in protein domains, retention of introns, initiation of nonsense-mediated decay, and emergence of intrinsically disordered regions. Moreover, we detected various alternative splicing events that may drive these structural alterations. We also found changes in the expression of long non-coding RNAs (lncRNAs) that may be involved in the aging process and disease resistance by regulating crucial genes in survival and metabolism. Through weighted gene co-expression network analysis, we have linked four lncRNAs with 29 genes, which contribute to protein complexes such as the Mili-Tdrd1-Tdrd12 complex. Beyond safeguarding DNA integrity, this complex also has a wider impact on gene regulation, chromatin structure, and metabolic control. Our detailed investigation provides insight into the molecular foundations of the remarkable health and longevity of df/df mice, emphasizing the significance of adipose tissue in aging and identifying new avenues for health-promoting therapeutic strategies.

Implementasi Program Waqaf Tunai dalam Pengentasan Kemiskinan di Indonesia

Cash waqf is a philanthropic concept that aims to collect funds from the community through donations which are then invested in building social, educational, health and economic infrastructure. This research aims to analyze the implementation of the cash waqf program in overcoming poverty in Indonesia. The research method used is literature study and analysis of secondary data related to the implementation of the cash waqf program in Indonesia, as well as its impact on improving community welfare. The research results show that the implementation of the cash waqf program has made a positive contribution in reducing poverty levels in Indonesia. These programs include the establishment of education centers, development of health infrastructure, business capital assistance for underprivileged communities, and local economic empowerment programs. However, there are still challenges in optimizing and managing waqf funds as well as developing sustainable programs to increase their wider impact. In conclusion, the implementation of the cash waqf program has great potential in overcoming poverty in Indonesia, but good coordination is needed between the government, sharia financial institutions and the community to ensure the sustainability and effectiveness of the program. This research provides useful insights for stakeholders in developing strategies and policies that support the growth of cash waqf as an effective instrument in alleviating poverty.

How Pharmaceutical Residues Occur, Behave, and Affect the Soil Environment.

Many pharmaceuticals (PhMs), compounds for the treatment or prevention of diseases in humans and animals, have been identified as pollutants of emerging concern (PECs) due to their wide environmental distribution and potential adverse impact on nontarget organisms and populations. They are often found at significant levels in soils due to the continuous release of effluent and sludge from wastewater treatment plants (WWTPs), the release of which occurs much faster than the removal of PhMs. Although they are generally present at low environmental concentrations, conventional wastewater treatment cannot successfully remove PhMs from influent streams or biosolids. In addition, the soil application of animal manure can result in the pollution of soil, surface water, and groundwater with PhMs through surface runoff and leaching. In arid and semiarid regions, irrigation with reclaimed wastewater and the soil application of biosolids are usual agricultural practices, resulting in the distribution of a wide number of PhMs in agricultural soils. The ability to accurately study the fate of PhMs in soils is critical for careful risk evaluation associated with wastewater reuse or biosolid return to the environment. The behavior and fate of PhMs in soils are determined by a number of processes, including adsorption/desorption (accumulation) to soil colloids, biotic (biodegradation) and abiotic (chemical and photochemical degradation) degradation, and transfer (movement) through the soil profile. The sorption/desorption of PhMs in soils is the main determinant of the amount of organic chemicals taken up by plant roots. The magnitude of this process depends on several factors, such as crop type, the physicochemical properties of the compound, environmental properties, and soil-plant characteristics. PhMs are assumed to be readily bioavailable in soil solutions for uptake by plants, and such solutions act as carriers to transport PhMs into plants. Determining microbial responses under exposure conditions can assist in elucidating the impact of PhMs on soil microbial activity and community size. For all of the above reasons, soil remediation is critical when soil pollutants threaten the environment.

Introduction to the Special Issue Commemorating the 170th Anniversary of the 1853–1854 Preston Lock-Out

This introduction to the special issue commemorating the 170th anniversary of the Preston strike and lock-out of 1853–1854 explains the significance of one of the most famous industrial disputes of the nineteenth century, updates its historiography since the publication of H.I. Dutton and J.E. King’s 1981 study, ‘Ten Per Cent and No Surrender’: The Preston Strike, 1853–1854 , provides context and a chronology, and summarises the eight articles of new research presented here. The articles examine women’s impact on the dispute and its impact on them, the role of Irish workers, the question of intimidation and conflict between workers, cultural and literary expressions of the dispute, its significance and legacy, and one creative interpretation of it, using animation. The editors argue that the Preston strike and lock-out had a wide impact, was widely reported, and had a strong cultural resonance, making it a microcosmic episode of mid-Victorian Britain. This article was published open access under a CC BY-NC-ND licence: https://creativecommons.org/licenses/by-nc-nd/4.0/

A Chemoselective Enrichment Strategy for In-Depth Coverage of the Methyllysine Proteome.

Proteomics is a powerful method to comprehensively understand cellular posttranslational modifications (PTMs). Owing to low abundance, tryptic peptides with PTMs are usually enriched for enhanced coverage by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Affinity chromatography for phosphoproteomes by metal-oxide and pan-specific antibodies for lysine acetylome allow identification of tens of thousands of modification sites. Lysine methylation is a significant PTM; however, only hundreds of methylation sites were identified by available approaches. Herein we report an aryl diazonium based chemoselective strategy that enables enrichment of monomethyllysine (Kme1) peptides through covalent bonds with extraordinary sensitivity. We identified more than 10000 Kme1 peptides from diverse cell lines and mouse tissues, which implied a wide lysine methylation impact on cellular processes. Furthermore, we found a significant amount of methyl marks that were not S-adenosyl methionine (SAM)-dependent by isotope labeling experiments.

A Chemoselective Enrichment Strategy for In‐Depth Coverage of the Methyllysine Proteome

AbstractProteomics is a powerful method to comprehensively understand cellular posttranslational modifications (PTMs). Owing to low abundance, tryptic peptides with PTMs are usually enriched for enhanced coverage by liquid chromatography‐mass spectrometry/mass spectrometry (LC–MS/MS). Affinity chromatography for phosphoproteomes by metal‐oxide and pan‐specific antibodies for lysine acetylome allow identification of tens of thousands of modification sites. Lysine methylation is a significant PTM; however, only hundreds of methylation sites were identified by available approaches. Herein we report an aryl diazonium based chemoselective strategy that enables enrichment of monomethyllysine (Kme1) peptides through covalent bonds with extraordinary sensitivity. We identified more than 10000 Kme1 peptides from diverse cell lines and mouse tissues, which implied a wide lysine methylation impact on cellular processes. Furthermore, we found a significant amount of methyl marks that were not S‐adenosyl methionine (SAM)‐dependent by isotope labeling experiments.

Dengue Seroprevalence in Different Geographic Zones of India: A Systematic Review and Meta-Analysis of Cross-Sectional Studies

Dengue is a highly prevalent mosquito-borne disease that is endemic in over 100 countries. It has a wider impact in terms of severity of illness and mortality risk in the absence of an effective vaccine as yet. The purpose of this study was to use meta-analysis to find out how common the dengue virus (DENV) is in India based on public data and to figure out how much of a problem. We searched, read, and reviewed about DENV in India that were available online. Forty-four cross-sectional studies were selected from the 178 records. There were reports of dengue cases in 14 out of the 28 states. Out of the patients presenting with symptoms of Dengue 27% of people were confirmed to have DENV infection with 82.29% (95% CI. 81-84%), having dengue IgM, 41.67% (95% CI: 40.16-43.43), having dengue IgG, and 23.97% (95% C.I. 14-43%), having both IgG and IgM from positive sample n=27156. Hospital-based cross-sectional studies on suspected Dengue-like illness (DLI) found that 99.48% of people had confirmed dengue out of the patients with features of DLI, and community-based studies found that 0.52% of DLI cases had dengue. The seroprevalence rates for East, South, North, and Western regions were 35.38% (95% C.I.14-31%), 11.57% (95% C.I. 2-69%), 38.10% (95% C.I. 9-61%), and 14.87% (95% C.I. 6-38%) correspondingly. DENV is interestingly spreading across the whole country, and the disease’s frequency varies a lot from place to place and from 2010-2023. However this review does not find appropriate published literature from 50% of the Indian states. The identification of IgG-class antibodies to dengue virus is indicative of prior exposure to this pathogen. Almost all immunocompetent individuals should have developed IgG antibodies against the dengue virus within three weeks of exposure. The presence of dengue virus IgM-class antibodies is indicative of an acute phase of infection. National Vector borne Disease Control Programme (NVBDCP) has some surveillance information, appropriate designed research into prevalence and risk factors for DENV infection would be required to provide adequate information for public health intervention.

Adenomyosis-A Call for Awareness, Early Detection, and Effective Treatment Strategies: A Narrative Review.

To provide a brief summary of the high incidence, symptomatology, different types, and diagnosis of adenomyosis and to explore various aspects of the disease, with the primary aim of raising awareness among gynecologists for appropriate and early detection. Adenomyosis, a benign gynecological condition characterized by the infiltration of endometrial tissue into the myometrium, poses significant challenges to women's reproductive health. A narrative review was conducted by searching PubMed, Scopus, and Cochrane databases and offering a non-systematic summary and critical analysis of current knowledge on the impact of adenomyosis on women's health. Articles published in the English language up to May 2023, including original scientific papers, clinical trials, meta-analyses, and reviews focusing on various aspects of adenomyosis, were included in the synthesis of this review. Approximately 20% of women are affected by adenomyosis, which manifests with various subtypes, distinct epidemiological profiles, symptomatology, and treatment responses. Despite its clinical significance, adenomyosis remains understudied, resulting in a significant disparity in research and the literature compared to other gynecological conditions. The severity of adenomyosis is compounded when coexisting with endometriosis, particularly deep-infiltrating endometriosis (DIE), leading to exacerbated fertility issues and severe symptomatology. The wide range of symptoms, including adverse pregnancy outcomes such as pre-eclampsia, highlights its wider impact and emphasizes the need for increased awareness of the condition. Adenomyosis is frequently associated with treatment failure in endometriosis, contributing to dienogest resistance, elevated discontinuation rates, and persistent pain post-endometriosis surgery. Additionally, the lack of specific treatments tailored to adenomyosis poses a considerable challenge in clinical management.

Novel approaches to psoriatic onychopathy diagnostics and treatment

Psoriasis is one of the most important problems in the clinical practice of a dermatovenereologist. In addition to damage of the skin and joints, the nail involvement is often seen in psoriatic patients. Despite its wide prevalence and significant impact on the quality of life, psoriatic onychopathy is discussed relatively rare. A change in the nails may indicate early alterations in the small joints of the palms, еthat foster to suspect psoriatic arthritis at an earlier time. Besides, the severity of nails lesions determined on the base of the NAPSI index correlates directly with the severity of pain in enthesitis. Nails damage in psoriasis does not entail persistent functional disorders, but significantly affects the patient’s quality of life due to a visible cosmetic defect. In addition, psoriatic onychopathy is difficult to treat. The use of topical agents is impractical, and systemic therapy gives a weak clinical response over a longer period. Even in the absence of a pathological process on the skin, nail psoriasis may persist much longer, which causes significant discomfort to patients. The study of pathomorphological aspects and mechanisms of nail psoriasis development will allow to disover a new methods for the effective treatment of psoriatic onychopathy.

Analysis of Topological Properties and Robustness of Urban Public Transport Networks

With the acceleration of urbanization, public transport networks are an important part of urban transport systems, and their robustness is critical for city operation. The objective of this study is to analyze the topological properties and robustness of an urban public transport network (UPTN) with a view to enhancing the sustainability of urbanization. In order to present the topological structure of the UPTN, the L-Space complex network modeling method is used to construct a model. Topological characteristics of the network are calculated. Based on single evaluation indices of station significance, a comprehensive evaluation index is proposed as the basis for selecting critical stations. The UPTN cascading failure model is established. Using the proportion of the maximum connected subgraph as the evaluation index, the robustness of the UPTN is analyzed using different station significance indices and deliberate attack strategies. The public transport network of Xuzhou city is selected for instance analysis. The results show that the UPTN in Xuzhou city has small-world effects and scale-free characteristics. Although the network has poor connectivity, it is a convenient means to travel for residents with many independent communities. The network’s dynamic robustness is demonstrably inferior to its static robustness due to the prevalence of cascading failure phenomena. Specifically, the failure of important stations has a wider impact on the network performance. Improving their load capacity and distributing the routes via them will help bolster the network resistance against contingencies. This study provides a scientific basis and strategic recommendations for urban planners and public transport managers to achieve a more sustainable public transport system.

CORRELATION BETWEEN DEPRESSION LEVEL AND LIFE QUALITY OF HIV PATIENTS AT POLY VCT REGIONAL GENERAL HOSPITAL PROF.DR. SOEKANDAR, MOJOKERTO

Life quality of HIV (Human Immunodeficiency Virus) patients is important to note because this infectious disease is chronic and progressive so that it has a wide impact on all aspects of life both physical, psychological, social, and spiritual. Psychosocial problems especially depression is more severe faced by patients so that it can reduce the life quality. The purpose of this study is to explain the relationship between depression and life quality in HIV patients. The design of this study used correlation analytic with non-probability sampling of consecutive types, conducted on June 23 until June 30, 2020, with 52 respondents. The research instrument used the WHO Life quality-BREF questionnaire to evaluate life quality and Beck Depression Inventory II to evaluate depression levels. The results of the study were tested with Spearman Rho and showed the level of depression in the non-depression category of (17.3%) 9 respondents in the mild category (13.5%) 7 respondents in the moderate category (32.7%) 17 respondents and in the severe category (36.5 %) 19 respondents and good life quality (42.3%) 22 respondents and poor category (57.7%) 30 respondents. From the results of the study obtained p value = (0,000) <α (0.05), which showed that there was correlation between depression level and life quality of HIV patients at Poly VCT Regional General Hospital Prof. Dr. Soekandar, Mojokerto. Depression contributed to a decrease in life quality of HIV patients, psychological burdens on sufferers such as sufferers felt pessimistic about the future, seeing themselves as worthless could have a dominant effect on decreasing life quality of HIV patients.

Record‐breaking heatwave in North China during the midsummer of 2023

AbstractIn midsummer 2023, a record‐breaking extreme heatwave hit North China, causing significant impacts on people's daily lives and production. This study comprehensively analysed the unique features of this extreme event based on five indices describing the intensity, frequency and impact range. The results show that four of these indices broke the historical record in 2023, and the spatial extent (Tmax >40°C) is the second highest in history. The number of hot days with Tmax >40°C (Tmax >35°C) even reached 23 times (4.2 times) the normal. The combined results of these five indices undoubtedly indicate that this heatwave event is featured by high intensity, long duration, numerous extremely hot days and wide impact range. Furthermore, physical mechanism study revealed that the abnormally warm high‐pressure system persisted in dominating North China, resulting in descending airflow and temperature increases. The enhanced and unprecedented westward extending Western North Pacific Subtropical High, the enhanced and eastward extending Iran Subtropical High and the abnormal high‐pressure over southwestern China form an east–west connected anomalous high‐pressure zone, blocking the water vapour transport from lower latitude oceans to North China. Noticeably, North China has experienced a reduction in precipitation since about 2 months preceding this extreme heatwave, leading to severe soil moisture deficiency and reduced evaporation. Consequently, it increased surface sensible heat flux that led to a rise in temperature. This local land‐atmosphere positive feedback mechanism plays a crucial role in the intensification and maintenance of this extreme heatwave event.

Globalization, Mass Media, and the Social Changes of India

Globalization is now a universal term that is conventionally accepted throughout the globe. It tries to suggest a common global civilization and a unified world. Globalization spread its wings and touched almost every corner of the globe. However, in India, it has also shown its existence in various fields. The touch of globalization has a wide impact on Indian society and the mass media enhances the pace of the impact. Globalization brings a wide range of foreign cultures and mass media continuously propagates those cultures among the Indian society. After the amalgamation of the foreign cultures with the Indian one, social change are taking place and developing a hybrid culture. The article entitled ‘Globalization, Mass Media and the Social Changes of India’ makes a thorough analysis and shows how globalization with the help of mass media developed a hybrid culture and how hybrid cultures dominate the Indian social system.

Basic Concepts of Disaster Management and Hazard Risk Vulnerability Profile of Gurgaon Based on District Disaster Management Plan 2020

To understand the process of disaster risk reduction and disaster management it is very important to know the usage meaning and difference between the basic concepts of disaster management. While hazard refers to probable event that can occur, disaster is actual occurrence of the event. Any event becomes a disaster after occurrence when it has very wide impact in terms of loss of life, injury to people, damage and destruction of physical structures and environment. Similarly, vulnerability is situation it can be physical, social or economic but risk is calculation of probable impact of disaster. Capacity improvement can lower the vulnerability, lower the risk and lower the total impact of disaster. Capacity improvement by building strong structures and creating awareness among communities will help in building a resilient society to cope with disasters. In this paper we tried to understand the meaning of these basic concept with illustrations from District Disaster Management Plan 2020 of Gurgaon District of Haryana