Full duplex-in band (FDIB) is a well-established solution for increasing the data rate and spreading the link range for future communication systems. FDIB systems need no additional bandwidth requirement. However, they are confronted with a major interference challenge on the same site, called co-site interference (CSI). Long-established co-site interference cancellation (CSIC) methods achieve a cancellation depth upto 35 dB, conversely it has space containments, manufacturing imperfections, induces noise penalties and limits isolation bandwidth. To overcome these problems, RF photonic CSIC methods have been developed, which have produced 30 dB wide-band interference suppression. They also increase bandwidth, have a flexible structure, minimize losses and prevent periodic power fading. But these systems have a problem of inherent DC drift, low maintenance of coherence, and low isolation at low transmission power. Thus, there is a high need for photonic CSIC designs of FDIB systems that operate over wider bandwidths and at higher transmission powers. Here, a newfangled CSIC system based on a non-linear photonic loop and frequency down-conversion is proposed. It shows excellent CSIC suppression of greater than 61 dB, for a single frequency signal of interest (SOI) with maximum RF power of 13 dBm. Without frequency down-conversion, the system maintains an average cancellation depth of 62.541 dB for single frequency SOI. After frequency down conversion, the system maintains an average cancellation depth of 61.208 dB for narrow band SOI. The system attains 18% error vector magnitude at −20 dB RF output power, which confirms the comprehensive quality of the system.