Consumption Of Whole Grains Research Articles

Unhealthy plant-based diet is associated with a higher cardiovascular disease risk in patients with prediabetes and diabetes: a large-scale population-based study

BackgroundThe role of plant-based dietary patterns in preventing cardiovascular disease (CVD) among individuals with prediabetes and diabetes remains unclear. We aimed to evaluate the associations of plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI) with cardiovascular disease (CVD) risk and explore potential contributing factors among people with prediabetes and diabetes.MethodsA total of 17,926 participants with prediabetes and 7798 with diabetes were enrolled from the UK Biobank between 2006 and 2010 and followed until the end of 2020. We calculated the PDI, hPDI, and uPDI based on 18 major food groups including plant-based foods and animal-based foods and applied Cox proportional hazard models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD risk related to PDI, hPDI, and uPDI. Decomposition analysis was performed to assess the role of dietary components, and mediation analysis was performed to assess the potential mediating role of serum biomarkers underlying these associations.ResultsA total of 2324 CVD events were documented among individuals with prediabetes, while 1461 events occurred among patients with diabetes. An inverse association was found between hPDI and CVD risk among individuals with prediabetes (HR T3 vs. T1 = 0.88, 95% CI = 0.79–0.98, Ptrend = 0.025) but not those with diabetes. A positive association was found between uPDI and CVD risk among individuals with prediabetes (HR T3 vs. T1 = 1.17, 95% CI = 1.05–1.30, Ptrend = 0.005) and those with diabetes (HR T3 vs. T1 = 1.14, 95% CI = 1.00–1.29, Ptrend = 0.043). High-sugar-sweetened beverages (SSB) intake accounted for 35% of the hPDI-CVD association and 15% of the uPDI-CVD association among individuals with prediabetes, whereas low intake of whole grain accounted for 36% of the association among patients with diabetes. Elevated cystatin C levels explained the largest proportion of the association between uPDI and CVD risk among individuals with prediabetes (15%, 95% CI = 7–30%) and diabetes (44%, 95% CI = 9–86%).ConclusionsAdherence to an unhealthy plant-based diet is associated with a higher CVD risk in people with prediabetes or diabetes, which may be partially attributed to low consumption of whole grains, high intake of SSB, and high blood cystatin C levels.

Assessment of manganese accumulation in dryland wheat grains via plastic film mulching: Implications for human health risk in multi-site studies

Crop manganese (Mn) accumulation and the associated human health risks stemming from excessive intake of high Mn crop foods have attracted attention. However, there is limited information available concerning the impact of plastic film mulching (PFM) on Mn concentration in cereal grains and the health risks associated with Mn intake by the human body. Field experiments were conducted from 2014 to 2016 at seven sites in the drylands of a typical wheat-growing region in China to assess the effect of PFM on grain Mn concentration, Mn accumulation and distribution in winter wheat plants, and the potential risk of Mn intake and optimal grain intake for human health. The multi-site study results revealed that grain Mn concentration and bioavailability were significantly higher under PFM compared to no mulching. Similarly, PFM was found to enhance aboveground Mn accumulation at the anthesis stage by 17.5 %, Mn harvest index by 3.9 %, grain Mn accumulation by 28.9 %, and available Mn concentration in the soil by 10.9 %. The increased uptake and accumulation of Mn in wheat plants, leading to elevated grain Mn concentration, were primarily attributed to the improved availability of Mn and moisture in the soil under PFM treatment. Furthermore, a health risk assessment indicated that long-term consumption of whole wheat grains from PFM treatment could potentially pose a non-carcinogenic risk of Mn for children and adolescents residing in rural areas. Therefore, this study established upper limits for daily consumption of whole wheat grains based on the specific needs of local residents. The findings of this research underscore the potential health risks associated with consuming grain crops grown in PFM crop production systems.

Initial implicit association between whole grains and taste does not predict consumption of whole grains in low-whole grain consumers: a pilot randomized controlled trial.

Health benefits of whole grain (WG) consumption are well documented. Current Dietary Guidelines for Americans recommend at least half of total grains consumed be WG; however, Americans consume less than one serving of WG per day. Inferior taste of whole grain products as compared with refined grain products has been reported as one of the main barriers to acceptability and consumption of whole grains. In this pilot study, we aimed to determine if mere exposure to WG foods in self-reported low WG consumers would improve their implicit associations between WG and pleasant taste. Healthy adults (n=45) were provided a variety of WG or refined grain (RG) products for home use for 6 weeks. Intake was measured by calculating disappearance and verified by a daily log. At the beginning and end of the intervention, we administered an Implicit Association Test (IAT), a computer test designed to measure indirectly the strength of association between pairs of concepts: (a) two contrasted target categories (WG and RG food images) and (b) two contrasted attribute categories (words relating to pleasant or unpleasant taste) via a classification task. Response time was used to calculate IAT D scores, indicating the strength of implicit associations between WG and RG and positive or negative taste. ANCOVA showed that average D scores at the end of the study shifted significantly toward a positive implicit association between WG and good taste (p<0.05) in participants whose baseline D scores indicated an initial preference for RG over WG. No significant differences were found between the WG and RG groups in overall consumption of provided grain products. These findings suggest that mere exposure to WG products over an extended period of time in a free-living situation can improve automatic attitudes toward WG, potentially leading to increased consumption of WG foods. Clinicaltrials.Gov, identifier NCT01403857.

Fatores de risco e sua influência na Síndrome Metabólica: Uma revisão narrativa da literatura

Objective: To analyze risk factors and their influence on Metabolic Syndrome. Literature Review: METABOLIC SYNDROME (MS) represents a set of risk factors of metabolic origin that promote the development of cardiovascular diseases and type 2 diabetes mellitus (DM). Regardless of the group or entity that defines MS, the risk factors, that is, the components adopted for its definition, are practically the same. The following components are included: obesity (especially abdominal obesity), high blood pressure levels, glucose metabolism disorders, and hypertriglyceridemia and/or low levels of HDL cholesterol. Final considerations: It is noteworthy that dietary factors can play a fundamental role both in the individual components and in the prevention and control of MS. Recent data associate the presence of MS with lower consumption of whole grains, fruits, and vegetables. There is a close relationship between these foods and dietary fiber, and it is likely that soluble fibers are more directly related to these effects

Wheat Germ Agglutinin (WGA): Its Nature, Biological Role, Significance in Human Nutrition, and Possibility to Be Used as Marker of Whole-Grain Status in Wheat-Based Foods.

The growing scientific evidence on the health benefits of whole-grain food consumption has promoted the manufacturing of a great number of products differing in quality and content of whole-grain components. This is particularly true for commercial wheat-based products where it is not always clear how much whole wheat is present considering that in many cases, they are manufactured from reconstituted mill streams and that there is not a standardised globally accepted definition and metrics to objectively evaluate whole-grain status. Attempts have been made to assess the level of "wholegraininess" in wheat products by measuring specific constituents that correlate with different wheat tissues, especially those that are expected to be found in a true whole-grain wheat product. Wheat germ agglutinin (WGA), a small lectin protein present exclusively in the wheat-germ tissues, has been indicated by several scientists as one of these constituents and after founding that its level changes depending on the amount of germ found in a wheat flour, it has been indicated as a biomarker of whole-grain status for wheat products. In this review, the biochemistry of WGA, its methods of detection, and current knowledge on its possibility to be practically utilized as a reliable marker are critically discussed.

Health promotion through the adoption of the mediterranean diet as a therapeutic proposal in the treatment and prevention of metabolic syndrome: a systematic review

Introduction: Excessive weight gain generates comorbidities, many of which are characterized as metabolic syndrome (MetS). It is important to highlight the association of MetS with cardiovascular diseases, increasing global mortality by approximately 1.5 times and cardiovascular mortality by approximately 2.5 times. In this sense, the Mediterranean diet presents itself as the main therapeutic proposal in the treatment of MetS, as it corresponds to caloric limitations without altering the patient's adequate nutritional status. Objective: It was to investigate the effects of health promotion through the adoption of the Mediterranean diet as a therapeutic proposal in the treatment and prevention of metabolic syndrome, evaluating the nutritional benefit on quality of life. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from April to June 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 157 articles were found. A total of 26 articles were evaluated in full and 21 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 29 studies with a high risk of bias and 28 studies that did not meet GRADE and AMSTAR-2. It was concluded that the studies showed the beneficial effects of the Mediterranean diet in reducing the prevalence of MetS. Furthermore, the dietary pattern described in the Mediterranean diet combined with physical activities can be used as a useful clinical tool in the treatment of metabolic syndrome. The suggested menu, with foods rich in fiber, is associated with reducing cardiovascular risk and, therefore, the Mediterranean diet is recognized as an agent for promoting health and preventing and treating obesity. In this sense, it appears that dietary factors can play a fundamental role both in the individual components and in the prevention and control of metabolic syndrome. Recent data associate the presence of MetS with lower consumption of whole grains, fruits, and vegetables. Therefore, there is a close relationship between these foods and dietary fiber, and, probably, soluble fiber is more directly related to these effects. A reduced prevalence of MetS was also observed in patients with systemic lupus erythematosus, a result of the good level of adherence to the Mediterranean diet. Furthermore, 25(OH)D status is associated with the composition, diversity, and functionality of the gut microbiota, and lifestyle intervention can modulate both the gut microbiota and 25(OH)D levels, potentially influencing metabolic pathways.

The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus

Metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), has become the leading cause of chronic liver disease worldwide. Optimal dietary intervention strategies for MAFLD are not standardized. This study aimed to achieve consensus on prevention of MAFLD through dietary modification. A multidisciplinary panel of 55 international experts, including specialists in hepatology, gastroenterology, dietetics, endocrinology and other medical specialties from six continents collaborated in a Delphi-based consensus development process. The consensus statements covered aspects ranging from epidemiology to mechanisms, management, and dietary recommendations for MAFLD. The recommended dietary strategies emphasize adherence to a balanced diet with controlled energy intake and personalized nutritional interventions, such as calorie restriction, high-protein, or low-carbohydrate diets. Specific dietary advice encouraged increasing the consumption of whole grains, plant-based proteins, fish, seafood, low-fat or fat-free dairy products, liquid plant oils, and deeply colored fruits and vegetables. Concurrently, it advised reducing the intake of red and processed meats, saturated and trans fats, ultra-processed foods, added sugars, and alcohol. Additionally, maintaining the Mediterranean or DASH diet, minimizing sedentary behavior, and engaging in regular physical activity are recommended. These consensus statements lay the foundation for customized dietary guidelines and proposing avenues for further research on nutrition and MAFLD.

Major types of diets in the management of metabolic syndrome and obesity: a systematic review

Introduction: Excessive weight gain generates comorbidities, many of which are characterized as metabolic syndrome (MS), in which the individual, to be diagnosed, must present three or more metabolic or anthropometric changes such as increased waist circumference, systemic arterial hypertension, hyperglycemia, hypertriglyceridemia, and reduced serum HDL levels. It is important to highlight the association of MS with cardiovascular diseases, increasing global mortality by approximately 1.5 times and cardiovascular mortality by approximately 2.5 times. In this sense, of the different types of diets such as the low-carb diet, very low-carb diet, and intermittent fasting diet, the traditional Brazilian diet, the DASH, and the Mediterranean diet stand out, as they present as the main therapeutic proposal in the treatment of MS. Objective: It was to carry out a systematic review to present the main types of diets in the management of metabolic syndrome, evaluating their effectiveness as a nutritional benefit in controlling health and quality of life. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from April to June 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE and AMSTAR-2 instrument and the risk of bias was analyzed appropriately. according to the Cochrane instrument. Results and Conclusion: 111 articles were found, and 30 were evaluated in full and included in this article, 21 of which were included in the systematic review. Considering the Cochrane tool for risk of bias, the global assessment resulted in 12 studies with a high risk of bias and 21 studies that did not reach GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=79.8%&gt;50%. It was concluded that the traditional Brazilian diet, DASH, and the Mediterranean diet have in common the characteristics of plant-based diet varieties that incorporate natural foods and reduce ultra-processed foods. These diets have shown good results for human health through the prevention and treatment of obesity in its different life cycles, and there is also evidence of a reduction in the risk of cardiovascular diseases and cancer in individuals with obesity. Furthermore, these diets promote a decrease in low-grade inflammation that affects individuals with obesity, having beneficial effects in reducing metabolic syndrome, even more so when added to physical activities. It has been shown that dietary factors can play a fundamental role both in the individual components and in the prevention and control of metabolic syndrome. Recent data associate the presence of metabolic syndrome with lower consumption of whole grains, fruits, and vegetables.

Association between Planetary Health Diet and Cardiovascular Disease: A Prospective Study from the UK Biobank.

The Planetary Health Diet index (PHDI) prioritizes the well-being of both individuals and the planet but has yielded mixed results on cardiovascular disease (CVD). Our aim was to assess the association between the PHDI and risk of CVD. A cohort of 118,469 individuals aged 40-69 years from the UK Biobank, who were free of CVD at 2009-2012 and followed-up to 2021. The PHDI was calculated using at least two 24-h dietary assessments and included 14 food groups, with a possible range from 0 to130 points. CVD incidence was defined as primary myocardial infarction or stroke and obtained from clinical records and death registries. During a 9.4-year follow-up, 5,257 incident cases of CVD were ascertained. When comparing the highest (89.9-128.5 points) versus the lowest quartile (21.1-71.1 points) of PHDI adherence, the multivariable-adjusted hazard ratio (95% confidence interval) was 0.86 (0.79, 0.94) for CVD, 0.88 (0.80, 0.97) for myocardial infarction, and 0.82 (0.70, 0.97) for stroke. The association was linear until a plateau effect was reached at 80 points of adherence to PHDI. Results remained robust when excluding participants with type 2 diabetes, including only those with three or more diet assessments, or excluding CVD cases in the first three years of follow-up. The food group components of the PHDI more strongly associated with reduced CVD risk were higher consumption of whole grains, whole fruits, fish and lower consumption of added sugars and fruit juices. In this large cohort of middle-aged and older British adults, adherence to the PHDI was associated with lower risk of CVD. These results provide empirical evidence that this dietary pattern, thought to be environmentally sustainable, benefits cardiovascular health.

Dietary interventions for Alzheimer's in Pakistan: The MIND diet perspective.

Dear Editor, Alzheimer’s disease (AD) stands as the prevalent type of dementia, making up 50–75% of total cases, and showing a higher incidence among elderly patients. (1). Pakistan is a lower-middle-income country with an estimated 150,000–200,000 patients affected by dementia (2). Nevertheless, the patient population faces inadequate healthcare resources, with only one neurosurgeon for every 1,000,000 patients (3). The Alzheimer's Association Facts and Figures Guidelines (2014) have highlighted diet as a modifiable risk factor in progression of AD (4). Thus, investigating lifestyle modifications in the early stages of AD to potentially alleviate the disease progression becomes imperative, considering the significant burden the disease imposes on the healthcare system. The MIND diet is a composite dietary approach, derived from both the Mediterranean and DASH diets. It underscores the consumption of leafy greens, berries, nuts, whole grains, fish, legumes, and poultry while advocating for the use of olive oil. Conversely, it discourages the intake of red meat, butter, cheese, pastries, and fried or fast-food items (5). Agarwal et al. investigated the impact of the MIND diet on AD pathology in 581 autopsied participants from the Rush Memory and Aging Project. Their research demonstrated a significant correlation between adherence to the MIND diet and a decline in overall disease pathology, particularly in the reduction of Beta-amyloid plaques (6). Furthermore, another study illustrated that increased compliance with the MIND diet was associated with a reduced risk of hippocampal sclerosis (HS), a neurodegenerative condition linked to AD, even after accounting for other factors, such as APOE-4 status and AD pathology (7). Moreover, Morris et al.'s longitudinal study on US participants found a 53% lower risk for AD among individuals who adhered closely to the MIND diet and a 35% lower risk for those with moderate adherence after a follow-up of approximately 4.5 years (8). These findings indicate a potential role for the MIND diet in reducing the risk of AD and slowing cognitive decline. A comprehensive literature search on PubMed and PakMediNet revealed a lack of research, evaluating the efficacy of the MIND diet in the management of AD in Pakistan. This underscores the inadequacy in the implementation of the MIND diet among the patients. Consequently, it is recommended that researchers submit research grant proposals about the efficacy of the MIND diet in AD to different funding organizations. ---Continue

Correlates of lifestyle patterns among children in Singapore aged 10 years: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study

ObjectiveTo characterise lifestyle patterns (comprising dietary and movement behaviour aspects) of children in Singapore and examine the correlates of these patterns.DesignAn observational study approach was used. Children recorded their diet and activities over two weekdays and two weekend days on a validated web-based assessment, My E-Diary for Activities and Lifestyle (MEDAL). Lifestyle patterns were derived using principal component analysis, and the correlations of these with multiple known determinants organised by distal, intermediate, and proximal levels of influence were studied.SettingChildren of the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort.ParticipantsTen-year-old children (n = 397).ResultsThree lifestyle patterns, “high snacks and processed food”, “balanced” and “mixed”, were identified. We focused on the more health-promoting “balanced” pattern, characterised by lower screen-viewing and higher consumption of fruits, vegetables, wholegrains, and dairy. Among the distal factors, girls were more adherent to the “balanced” pattern compared to boys, and children of parents with lower education levels were less adherent to this pattern. Among intermediate factors, children of mothers with higher diet quality were more adherent to the “balanced” pattern. Among the proximal factors, engagement in active transport, leisure sports, and educational activities outside of school were positively associated with the “balanced” pattern, whereas screen-viewing while travelling was negatively associated with this pattern. Having siblings, pet ownership, mother’s physical activity, parenting style, parental bonding, child’s outdoor time, and breakfast consumption were not associated with children’s lifestyle patterns.ConclusionsThese findings provide direction for future interventions by identifying vulnerable groups and contexts that should be prioritised.

Supermarket Opening in an Urban, Low-Income Community Was Not Found to Be Associated With Improvements in Dietary Outcomes for Most Residents in the First Year

BackgroundLimited access to healthy foods in low-income, racial and ethnic minority communities has been proposed as a critical factor contributing to health disparities. One policy option for improving access is to introduce supermarkets in low-income communities, but evidence increasingly points to null effects. ObjectiveThe aim of this study was to examine whether the introduction of a new supermarket in a public housing community, and proximity to it, were associated with improvements in residents’ dietary outcomes. It also explored whether these associations may be moderated by access and cost barriers to eating healthy at baseline. DesignA cohort of public housing residents were recruited from Jordan Downs, where the new supermarket was introduced, and from 2 comparison sites. Longitudinal data on outcomes and exposures were collected at baseline (2018-2019) and follow-up (2020-2021). Quasi-experimental variation in residents’ distance to the new supermarket was used to examine whether proximity to the supermarket was associated with dietary improvements. Participants/settingParticipants included 557 adult residents from 3 public housing sites in Watts, Los Angeles, CA. InterventionThe intervention is the opening of a new supermarket in the Jordan Downs community. The primary exposure measure is an indicator for whether residents lived in Jordan Downs vs in the comparison sites. The secondary exposure measure is residents’ driving distance to the new supermarket. Main outcome measuresSelf-reports of daily consumption of whole grains, dairy, fruits and vegetables, added sugar, red meat, processed meat, and overall healthiness of diet were obtained from surveys administered at baseline and follow-up. Statistical analyses performedDescriptive analyses examined households’ grocery shopping patterns after the new supermarket’s introduction. Analysis of covariance linear regressions models estimated the association between residents’ dietary outcomes at follow-up and the exposure measures, conditional on dietary outcomes at baseline and other covariates. ResultsProximity to the new supermarket was associated with a significantly higher probability of shopping there, particularly for households that reported an access or cost barrier at baseline. Overall, there were no statistically significant or practically meaningful differences observed in dietary outcomes between Jordan Downs residents and those in comparison sites, or between residents who lived at varying distances from the supermarket. Exploratory moderation analyses suggested some meaningful dietary benefits for those who had a frequent access barrier at baseline, but not for those without such a barrier, but there was mostly no evidence of moderation by price barrier at baseline. ConclusionsSupermarket opening in an urban, low-income, and racial and ethnic minority community was not found to be associated with improvements in dietary outcomes for most residents in the first year after its opening. Improving dietary outcomes in such communities may require a broader and nuanced approach that addresses varied barriers faced by residents.

Association between DASH diet and asthma symptoms among a large sample of adolescents: a cross-sectional study

BackgroundThe Dietary Approaches to Stop Hypertension (DASH) diet, which has a lot of emphasis on the consumption of fruits, vegetables, and whole grains, and on the other hand, the consumption of red meat and sodium is limited, due to its anti-inflammatory properties, which can be related to reducing the risk of asthma.ObjectivesThe aim of this study was to determine the relationship between the DASH diet and asthma symptoms among children and adolescents.MethodsThis cross-sectional study was conducted among7667 children (3414 boys and 4253 girls) aged 6–7 and 13–14 years living in central Iran. Dietary food consumption was assessed using a multiple-choice questionnaire. Logistic regression was used to obtain odds ratios for the association between the DASH-like diet with current asthma and asthma symptoms.ResultsOur findings revealed that higher adherence to a DASH-like diet resulted in lower odds of asthma confirmed by a doctor among the whole population (OR = 0.53; 95%CI: 0.36–0.76) and also in females (OR = 0.47; 95%CI: 0.29–0.78). Moreover, the higher adherence to the DASH-like diet was inversely associated with the chance of wheezing in the past 12 months in all subjects (OR = 0.67; 95%CI: 0.51–0.86) and in boys (OR = 0.57; 95%CI: 0.38–0.85).ConclusionThe findings of the present study showed that following the DASH diet can be associated with the improvement of asthma symptoms in children and adolescents. However, more research is needed to improve dietary recommendations for asthma prevention.

Association of Serum Trimethylamine-N-Oxide Concentration from Childhood to Early Adulthood with Age and Sex.

Primary prevention is the cornerstone of cardiometabolic health. In the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP), dietary counseling intervention was given to children from infancy to 20 years of age and a follow-up was completed at age 26 years. We investigated the associations of age, sex, gut microbiome, and dietary intervention with the gut metabolite and the cardiac biomarker trimethylamine-N-oxide (TMAO). Overall, 592 healthy participants (females 46%) from STRIP were investigated. Compared to the control group, the intervention group had received dietary counseling between ages 7 months and 20 years focused on low intakes of saturated fat and cholesterol and the promotion of fruit, vegetable, and whole-grain consumption. TMAO serum concentrations were measured by a liquid chromatography-tandem mass spectrometry method at ages 11, 13, 15, 17, 19, and 26 years. Microbiome composition was assessed using 16S rRNA gene sequencing at 26 years of age. TMAO concentrations increased from age 11 to 26 years in both sexes. At all measurement time points, males showed significantly higher serum TMAO concentrations compared to females, but concentrations were similar between the intervention and control groups. A direct association between TMAO concentrations and reported fiber intake was found in females. Gut microbiome analysis did not reveal associations with TMAO. TMAO concentration increased from childhood to early adulthood but was not affected by the given dietary intervention. In females, TMAO concentrations could be directly associated with higher fiber intake suggesting sex-specific differences in TMAO metabolism.

Bread and whole-grain consumption and weight change from middle- to late adulthood: The Hordaland Health Study (HUSK)

Bread and whole-grain consumption and weight change from middle- to late adulthood: The Hordaland Health Study (HUSK)

Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium longum

ABSTRACT Dietary fiber supplements are a strategy to close the ‘fiber gap’ and induce targeted modulations of the gut microbiota. However, higher doses of fiber supplements cause gastrointestinal (GI) symptoms that differ among individuals. What determines these inter-individual differences is insufficiently understood. Here we analyzed findings from a six-week randomized controlled trial that evaluated GI symptoms to corn bran arabinoxylan (AX; n = 15) relative to non-fermentable microcrystalline cellulose (MCC; n = 16) at efficacious supplement doses of 25 g/day (females) or 35 g/day (males) in adults with excess weight. Self-reported flatulence, bloating, and stomach aches were evaluated weekly. Bacterial taxa involved in AX fermentation were identified by bioorthogonal non-canonical amino acid tagging. Associations between GI symptoms, fecal microbiota features, and diet history were systematically investigated. AX supplementation increased symptoms during the first three weeks relative to MCC (p < 0.05, Mann-Whitney tests), but subjects ‘adapted’ with symptoms reverting to baseline levels toward the end of treatment. Symptom adaptations were individualized and correlated with the relative abundance of Bifidobacterium longum at baseline (rs = 0.74, p = 0.002), within the bacterial community that utilized AX (rs = 0.69, p = 0.006), and AX-induced shifts in acetate (rs = 0.54, p = 0.039). Lower baseline consumption of animal-based foods and higher whole grains associated with less severity and better adaptation. These findings suggest that humans do ‘adapt’ to tolerate efficacious fiber doses, and this process is linked to their microbiome and dietary factors known to interact with gut microbes, providing a basis for the development of strategies for improved tolerance of dietary fibers.

Association between whole-grain consumption, tryptophan metabolism and psychological distress: a secondary analysis of a randomised controlled trial.

This study aimed to investigate whether psychological distress, whole-grain consumption and tryptophan metabolism are associated with participants undergoing weight management intervention. Seventy-nine women and men (mean age 49·7 (sd 9·0) years; BMI 34·2(sd 2·5) kg/m2) participated in a 7-week weight-loss (WL) period and in a 24-week weight maintenance (WM) intervention period. Whole-grain consumption was measured using 4 d food diaries. Psychological distress was assessed with the General Health Questionnaire-12 (GHQ), and participants were divided into three GHQ groups based on the GHQ scores before WL. Tryptophan metabolites were determined from the participants' fasting plasma using liquid chromatography-MS. GHQ scores were not associated with the whole-grain consumption. A positive association was observed between the whole-grain consumption and indole propionic acid (IPA) during the WM (P = 0·033). Serotonin levels were higher after the WL in the lowest GHQ tertile (P = 0·033), while the level at the end of the WM was higher compared with other timepoints in the highest GHQ tertile (P = 0·015 and P = 0·001). This difference between groups was not statistically significant. Furthermore, levels of several tryptophan metabolites changed within the groups during the study. Tryptophan metabolism changed during the study in the whole study group, independently from the level of psychological distress. The association between whole-grain consumption and IPA is possibly explained by the effects of dietary fibre on gut microbiota. This broadens the understanding of the pathways behind the health benefits associated with the intake of whole grains.

Associations between whole grains intake and new-onset hypertension: a prospective cohort study.

Epidemiological evidences regarding the association between whole grain intake and the risk of new-onset hypertension are still controversial. We aimed to investigate the relationship between whole grain intake and new-onset hypertension and examine possible effect modifiers in the general population. A total of 10,973 participants without hypertension from the China Health and Nutrition Survey were enrolled, with follow-up beginning in 1997 and ending in 2015. Whole grain intake was assessed by 3 consecutive 24-h dietary recalls combined with a household food inventory. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression model after adjusting for potential risk factors. During a median follow-up of 7.0 years, 3,733 participants developed new-onset hypertension. The adjusted HRs (95% CIs) were as follows: for quartile 2 (HR: 0.52; 95% CI: 0.47-0.57), quartile 3 (HR: 0.46; 95% CI: 0.42-0.51), and quartile 4 (HR: 0.35; 95% CI: 0.31-0.38), compared with quartile 1. Different types of whole grain types, including wheat (adjusted HR, 0.35; 95% CI, 0.32-0.39), maize (adjusted HR, 0.50; 95% CI, 0.42-0.59), and millet (adjusted HR, 0.38; 95% CI, 0.30-0.48), showed significant associations with a reduced risk of hypertension. The association between whole grain intake and new-onset hypertension was stronger in individuals with older age (P for interaction < 0.001) and higher BMI (P for interaction < 0.001). Higher consumption of whole grains was significantly associated with a lower risk of new-onset hypertension. This study provides further evidence supporting the importance of increasing whole grain intake for hypertension prevention among Chinese adults.

Dietary patterns and metabolic syndrome in patients with premature heart disease: a cross-sectional study

PurposeDue to the increase in the prevalence of other risk factors of heart diseases, the age of heart disease has decreased and it has led to premature heart disease. One of the main risk factors of this disease is metabolic syndrome (MetS). One of the key ways to control MetS is dietary modification. The purpose of this study is to investigate the relationship between dietary patterns and MetS in patients with premature heart disease.Design/methodology/approachThis study was conducted on 409 people with premature heart disease. The diagnosis of MetS was made based on the ATP III criteria. Dietary intake for the past year was collected using the validated semi-quantitative food frequency questionnaire. Dietary patterns were determined by factor analysis with principal components approach.FindingsThree dietary patterns were identified, including the healthy, western and traditional patterns. The findings showed that people who followed the traditional pattern more than those who followed less had a lower risk of MetS. (OR:0.23; 95% CI: 0.11–0.52). But, no relation was observed between healthy (OR:1.45; 95% CI:0.64–3.25) and western (OR:1.04; 95% CI:0.51–2.13) patterns with MetS.Originality/valueThe findings of this study showed that following a traditional dietary pattern based on high consumption of whole grains, red meat, viscera, fish, eggs, high-fat dairy products, soft drinks, mayonnaise and solid oil was associated with a lower risk of MetS.

Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace.

Worksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. In this one-arm pre-post intervention study, we recruited 277 non-pregnant hospital employees aged 18-60 with prediabetes or pre-hypertension. The study was registered in clinicaltrials.gov (NCT03447340; 2018/02/27). All four cafeterias in the hospital premises received cafeteria intervention encouraging healthy foods and discouraging unhealthy foods for six months. We measured blood pressure, fasting glucose level, glycated hemoglobin, cholesterol in the laboratory, and diet intake (in servings per week) using 24-hour recall before and six months after the intervention. The before and after measures were compared using paired-t tests. After six months of cafeteria intervention, the median consumption of whole grains, mono/polyunsaturated fat, fruits, vegetable and nuts servings per week increased by 2.24(p<0.001), 2.88(p<0.001), 0.84(p<0.001) 2.25(p<0.001) and nuts 0.55 (p<0.001) servings per week respectively. The median consumption of refined grains decreased by 5.07 servings per week (p<0.001). Mean systolic and diastolic blood pressure decreased by 2 mmHg (SE = 0.6; p = 0.003) and 0.1 mmHg (SE = 0.6; p = 0.008), respectively. The low-density lipoprotein (LDL) was significantly reduced by 6 mg/dL (SE = 1.4; p<0.001). Overall, we found a decrease in consumption of refined grains and an increase in consumption of whole grains, unsaturated fats, fruits, and nuts observed a modest reduction in blood pressure and LDL cholesterol following a 6-month cafeteria-based worksite intervention incorporating access to healthy foods.