The article examines the foreign policy of the United States of America in the Greater Middle East region, which acquired strategic importance after the end of World War II and the beginning of the Cold War with the Soviet Union. The subject of the study is the American-Iranian relations of 1953-1974, within the framework of which the Iranian Shah Mohammad Reza Pahlavi consistently built cooperation with D. Eisenhower, J. Kennedy, L. Johnson and R. Nikson. Despite the fact that their approaches to the implementation of American foreign policy in the Greater Middle East underwent significant changes, the desire to maintain influence in the country, consolidate control over cheap Iranian energy resources and prevent the return of Soviet influence on Iran remained the main directions of American activity. The methodological basis of the research is based on the principles of historicism, objectivity and consistency. The following methods were used in the work: historical-comparative, historical-typological and historical-systemic methods. The reviewed diplomatic documents of the United States of America "Foreign Relations of the United States" allow us to establish that the influence of the oil factor on American-Iranian relations in 1953-1974 remained high, despite changes in the approaches of the presidents to the implementation of foreign policy in the region. The return of Iranian oil to the global market allowed Shah Mohammad Reza Pahlavi to initiate the start of the "white revolution", supported by the United States, among others. Huge oil revenues allowed Iran in a short time not only to realize its claims in the region, but also to become an important ally of the United States, responsible for regional security during the presidency of R. Nixon. The work illustrates the changing role of the United States of America and Iran in the Greater Middle East, due, among other things, to the influence of the oil factor.