The wheel slide protection control system for rail vehicles plays a crucial role in ensuring a consistent braking performance in all operating environments, making it a vital factor in the safety and efficiency of rail transportation. In this paper, a hybrid approach to wheel slide protection control is presented, which combines the rule-based control strategy and the model-based control methods using adhesion force estimation. Model-based control usually relies on mathematical models to characterize the vehicle dynamics, requiring online estimators to be designed or extra sensors to be added for practical application. Rule-based control operates on predefined rules and thresholds and the available data from vehicles in service. A comparative test was conducted between the traditional rule-based control strategy and the proposed combined control strategy using a semi-physical simulation test bench. The performance differences of the control strategies were analyzed from two perspectives: adhesion utilization and air consumption. It was observed that among the traditional 2-phase, 3-phase, 4-phase and the optimized 4-phase combined control method, the combined control strategy has the best adhesion utilization and the traditional 4-phase control strategy has the least air consumption.