Western Nations Research Articles

Content Validity of Teacher's Evaluation of Neurodevelopmental Delays (TEDD) Tool for Indian Preschoolers.

Early detection of developmental delays in children can significantly help them realise their full potential. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), is the system in use at the moment to detect neurodevelopmental delays among children in the United States and other Western nations. However, due to cultural differences, there is a pertinent need for a content-validated module in the context of low- and middle-income countries, including India. The aim of this study was to develop and validate Teacher's Evaluation of Neurodevelopmental Delays (TEDD) tool based on the criterions and definitions of neurodevelopmental disorders as mentioned in DSM-V and then synced with developmental milestones mentioned in International Classification of Diseases, 10th revision (ICD-10) and Early Childhood Care and Education (ECCE)/ New York City Early Education Centre (NYCE) framework, and items were worded in behavioural terms. We did a thorough review of the literature for the development of TEDD tool and used modified Delphi technique to content validate it. Data from nine experts, such as doctors, clinical psychologists, special educators, speech and language and applied behaviour analysis therapist were used for the analysis. Analysis resulted into 28 items being retained which can be applied in the Indian context. This study has shown good content validity of the TEDD tool. Future studies are being planned to rule the feasibility and reliability of this tool.

Suicidal risk among Chinese parents of autistic children and its association with perceived discrimination, affiliate stigma and social alienation

BackgroundCaring for autistic children becomes challenging and may lead to negative psychological outcomes, even increasing the suicide risk (SR). Researchers have studied the SR among parents of autistic children in Western nations, but little is known about it in China and how it relates to perceived discrimination (PD), affiliate stigma (AS), and social alienation (SA). The current study aimed to reveal the SR prevalence rate among Chinese parents of autistic children, and clarify whether AS and SA may play mediating roles in the association between SR and PD.MethodsA total of 645 Chinese parents of autistic children were recruited to complete a series of scales to evaluate SR, SA, AS, and PD using the Suicidal Behaviors Questionnaire-Revised (SBQ-R), Perceived Discrimination Scale for Parents of Children with Autism Spectrum Disorders (PDS-FP), Affiliate Stigma Scale (ASS), and General Social Alienation Scale (GSAS), respectively. Then, the SR prevalence rate among Chinese parents of autistic children was evaluated; and the multiple mediation analysis and structural equation modeling with the bootstrap method were conducted to test the mediating effects of AS and SA in the association between SR and PD.Results34.6% Chinese parents of autistic children had high SR. In particular, the incidence rate of suicide ideation, suicide plans, suicide attempts, and suicide likelihood during the previous year were 49.8%, 11.9%, 2.5%, and 13.8%, respectively. Additionally, PD was positively associated with SR (r = .40, p < .01); and AS and SA showed significant mediating effects on the association between PD and SR (p < .01).ConclusionsThe current study evaluated the SR prevalence rate among Chinese parents of autistic children, and clarified the mediating effects of AS and SA in the association between SR and PD. Findings might bring new insights and guidance for intervention of suicidality among Chinese parents of autistic children.

Investigating whether offshore immigration detention and processing are associated with an increased likelihood of psychological disorders.

Immigration policies designed to deter people from seeking asylum are gaining traction in many Western nations, with the UK recently attempting to establish an offshore immigration processing centre in Rwanda. This letter outlines emerging evidence from Australia on the negative long-term psychological effects of offshore processing on people seeking asylum.

EPID-16. GENOMIC ANCESTRY-RELATED RISK RATIOS FOR GLIOBLASTOMA INCIDENCE AMONG GLOBAL POPULATIONS AND RACIAL/ETHNIC GROUPS WITHIN THE UNITED STATES

Abstract Glioblastoma (GBM) incidence varies globally, elevated rates in Europe and lower rates in Asia, Latin America, and Africa. While partially attributable to national differences in cancer diagnosis and reporting practices, analogous patterns exist within diverse Western nations. Ancestry-associated differences in GBM risk allele frequencies (RAFs) could contribute, a hypothesis supported by our prior multiethnic genome-wide association studies (GWAS). Leveraging variant effect estimates from large GBM GWAS datasets and ancestry-stratified allele frequency data from diverse reference populations (ALFA, GNOMAD, 1000 Genomes Project), we estimate the extent of GBM incidence differences across populations that can be attributed to underlying variation in RAF at the seventeen known GBM risk loci. Aggregate differences in RAF between global populations (Europe, West-Africa, East Asia) were associated with a &amp;gt;20% reduction in the normalized GBM risk-ratio (RR) in Africans compared to Europeans (RR=0.78) and a &amp;gt;50% reduction in East Asians compared to Europeans (RR=0.47). The frequency of GBM risk alleles was generally highest in Europeans, but four alleles found most commonly in Africans are at loci regulating telomere maintenance (TERC, TERT, OBFC1/STN1, RTEL1). We repeated analyses using RAF data from U.S. populations (African-Americans, Latinos, and non-Hispanic Whites). Compared to non-Hispanic Whites, aggregate differences in RAF were associated with a 15% reduction in GBM risk among African-Americans (RR=0.85) and a 28% reduction among Latinos (RR=0.72). We conclude that a sizable proportion of the reduced GBM incidence in Latinos and Asians, relative to non-Hispanic Whites, can be accounted for by population-level differences in RAF at known loci. However, registry-based analyses consistently report a two-fold lower incidence of GBM in African Americans relative to non-Hispanic Whites which is poorly explained by RAF differences at known loci. Further work is needed to identify structural, environmental, and biological factors contributing to unresolved differences in GBM incidence.

Student Satisfaction and University Enrollments: Does the Urban or Regional Status of Australian Higher Education Institutions Matter?

In the aftermath of World War II, Western nations witnessed unprecedented growth in university enrollments, particularly in business schools, driven by the expansion of the publicly funded higher education system. This growth has prompted higher education providers to re-evaluate the critical role of student satisfaction in shaping learning, engagement, and overall institutional success. While the impact of student satisfaction on engagement and academic outcomes is well documented, its influence on broader university enrollments remains underexplored. Using longitudinal data from the Australian Government-funded Quality Indicators for Learning and Teaching (QILT) surveys and universities’ annual reports (2012-2017), we find that universities with higher student satisfaction show significantly higher enrollment rates. Moreover, the positive impact of student satisfaction on enrollment is more pronounced in metropolitan universities. Beyond contributing to social justice theory, this study provides actionable insights for government and higher education management to improve equitable access to higher education and reduce social disparities through strategically allocating resources, capabilities, and support services.

Active non-alignment, the sovereignty paradox and the Russia-Ukraine war

ABSTRACT The differing reactions between Western nations and the Global South to Russia’s invasion of Ukraine present a puzzle. Shouldn't post-colonial states be just as concerned about the principles of national sovereignty and non-intervention as Western countries? The idiosyncratic, ad hoc explanations on a country-by-country basis are insufficient to account for a much broader phenomenon. This article deconstructs the “sovereignty principle” as it is seen in the Global South and examines the standing of the so-called Rules-Based Order (RBO), allegedly under mortal threat by Russia’s action. It then argues that a far better explanation for the Global South’s reaction is the rise of Active Non-Alignment (ANA). The foreign policy doctrine of ANA arose in Latin America in 2019–2020 in response to US–China tensions, It then spread to the rest of the Global South in 2022–2024 because of the war in Ukraine, BRICS expansion, and the war in Gaza.

The two faces of Franco-Sudanian Treaties: The peripheral practice of ratification as evidence of transregional international law in the nineteenth century

Abstract Legal scholars continue to revisit historical treaties between Western and non-Western nations to challenge long-standing accounts of non-Western peoples’ engagement with international law. Following this trend, new scholarship has stressed African agency in Euro-African treaty-making. However, legal scholars have generally overlooked African perspectives, pointing to a lack of sources. Focusing on nineteenth-century treaty-making between France and the polities of the Western Sudan in West Africa, this article excavates African perspectives through a novel reading of Euro-African treaties in an African context. This reading analyses treaties within the Western Sudan’s broader diplomatic corpus in both French and Arabic. By focusing on markers of translation, transcription, and negotiation left on different copies of treaties, this method brings to light arguments and practices that have been obscured in published European-language versions. Reading Franco-Sudanian treaties in a Sudanian context reveals that different norms governed the ratification of treaties in the Western Sudan and Europe. Treaties that scholars have long considered unratified were in fact ratified according to Western Sudanian norms, which designated the governor of French Senegal rather than the French president as the official competent to ratify treaties for France. However, when French officials sought to use treaties to claim sovereign rights in West Africa against Great Britain, they pressed the president to ratify them again. Presidential ratification thus served to transpose Franco-Sudanian treaties from an African to a Western normative order. Uncovering the African origins of Euro-African treaties thus reveals their differential operation across autonomous inter-polity orders.

Dark web and internet freedom: navigating the duality to facilitate digital democracy

ABSTRACT Internet freedom and the dark web are complex concepts riddled with misunderstanding. While the dark web is perceived as a negative space/state, internet freedom is seen as a positive space/state that many Western nations support. However, in practice, these perceptions are incomplete and overlook the close relationship between the tools and infrastructure that facilitate both the dark web and internet freedom. While the term dark web engenders fear and curiosity in the public and policymakers’ minds, the term internet freedom fails to describe the modern internet in a manner for effective governance to protect and empower citizens. Reframing how policymakers and the general public understand these terms will be essential for ensuring that future policies are effective, comprehensive and strive to facilitate digital democracy. This paper represents an extension of knowledge and a first step in technological policymaking by analysing and emphasising the relationship and duality between the dark web and internet freedom and their stakeholders from the cyberinfrastructure perspective. Furthermore, we propose new framing definitions for anonymous technology tools in the interest of facilitating digital democracy. We conclude by suggesting how to effectively integrate the redefined terminology into the framework of policy creation.

Cerebral venous sinus thrombosis - Current updates in the Asian context.

Background Cerebral venous sinus thrombosis (CVT) is a life-threatening cause of stroke in Asian countries. South Asia, comprising of India, Pakistan and Bangladesh and contributed to 40% of strokes in women. Major CVT registries are from the western nations, which differs from the Asian countries with respect to epidemiology, gender biases and risk factors. This review focusses on the various aspects of relevance in evaluation and management of patients with CVT in the Asian context. Summary The incidence of CVT is higher in Asia than in Western nations. Young age, female gender, especially in pregnancy and puerperal period, and dehydration appear to be the critical risk factors. Tropical infections like malaria, scrub typhus, and flaviviral encephalitis predispose to CVT. There is a higher prevalence of inherited thrombophilia in the Asian cohorts, contributing to prothrombotic states. Anticoagulation and supportive management offer excellent outcomes. Newer anticoagulants are safe and efficacious. In medically refractory cases, endovascular treatment offers modest benefits. Decompressive hemicraniectomy, when done early, offers mortality benefits in patients with large hemorrhagic venous infarctions. Key messages CVT is an important cause of stroke with high-burden in South Asian countries. Establishment of robust registries is the need of the hour; to study the natural history, course and outcomes and to develop management algorithms tailored to the available resources.

AFROCENTRIC PEDAGOGY APPROACH IN THE CURRICULUM OF EDUCATIONAL SYSTEM RENEWAL IN AFRICA: A CASE OF SOUTH AFRICA

The purpose of this paper is to conceptualize in greater detail the educational system approach that is being imposed into African countries, South Africa as a case in point. Over the past years, Sub-Saharan countries have and still experience indoctrinated educational system in which the content is mimicked from purported hegemonic states such UK, USA and other western counties inter alia. The problem of education retrogrades from the prior independence of African countries in the early 1960s wherein, the colonial masters organized and silently played a crucial role in shaping the formation of education in Africa; and not much has changed in terms of education since then. A particular concern is that the system of education might have designed to impoverish African people and perpetuate dependency to the western nations. Hence, at the core center of the educational system is the curriculum which seem to be inevitable and requires an alteration, particularly in South Africa. Therefore, the outlook of this paper is to critique and interrogate the system of education in South Africa looking at the socio-economic development and a continuous alteration in respect of the curriculum. The paper shows that for the realization of African renaissance, ideals of Africa Agenda 2063 and accelerated development, the system of education must be transformed and be Africanized to benefit the people of Africa. The paper uses literature-based approach as a methodological framework in order to analyze the status quo of education in South Africa. The paper concludes and recommends that the transformation of current educational system requires an alteration to the inclusive of indigenous knowledge to vigorously respond to socio-economic woes in Africa. Furthermore, the paper advocates for indigenous knowledge consideration in the incessant curriculum renewal.

Decoding the Knacks of Ellagitannin Lead Compounds to Treat Nonalcoholic Fatty Liver Disease using Computer-aided Drug Designing.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing globally, impacting individuals in Western nations and rapid growing in Asian countries due to sedentary lifestyles; thus, NAFLD has emerged as a significant worldwide health concern. Presently, lifestyle changes represent the primary approach to managing NAFLD. This research aimed to identify the potential drug targets for treating NAFLD through comprehensive in silico computational analysis. These include the prediction of the three-dimensional structure of the protein, the prediction of inhibitors by PubChem and ZINC, molecular docking by Autodcok, pharmacophore modeling, molecular dynamics simulation by the OPLS_2005 force field, and the orthorhombic box solvent model Intermolecular Interaction Potential 3 Points Transferable to the selected compound. The toxicity of the lead compounds was analyzed through AdmetSAR software. The protein associated with the PNPLA3 gene, whose overall three-dimensional structure was 95% accurate, were retrieved following inhibitor selection via PubChem and ZINC. Among the selected inhibitors and docked compounds with ID 10033935 (ellagitannin) showed a minimum E-Score of -17.266. In docking and pharmacophore modeling the compound ellagitannin shows promise as a potential drug candidate. Moreover, the molecular dynamics and structural stability of the protein-ligand complex were evaluated with several metrics such as as root mean square fluctuation and root mean square deviation and resulted in the stability not only of PNPLA3-10033935 (ellagitannin) but also of compound PNPLA3-71448940 and PNPLA3-5748394 complexed proteins at 400 ns with very slight variation. Overall, ellagitannin was identified as the best druggable target with the best therapeutics profile. The findings of our study can pave the way for the development of a new drug against NALFD.

Dietary Risk Factors: Fiber and Beyond

AbstractThe incidence of diverticulosis continues to rise throughout western nations with collateral increases in the frequency of diverticulitis. However, the mechanism behind the transition from asymptomatic diverticulosis to complicated diverticulitis is incompletely understood. Dietary intake has long been investigated as one of, if not the main, links in the continuum of disease. As the world's diet continues to evolve with increasingly prevalent processed and high-fat food, longitudinal studies have emerged with a goal of finally explaining how diet influences the development of diverticulitis. While low-fiber, high-fat diets are believed to play a role in the development of an index episode of diverticulitis, the role in recurrent disease remains uncertain. More recent avenues of interest include the role of the microbiome, probiotics, and adjunct treatments such as 5-ASA and rifaximin. While robust longitudinal studies have identified an association between low-fiber, high-fat diets and the development of index diverticulitis, the impact of dietary composition and modification on disease recurrence remains unclear and fails to meet the threshold for societal recommendations.

Suppression of aldehyde dehydrogenase 2 in kidney proximal tubules contributes to kidney fibrosis through Transforming Growth Factor-β signaling

Chronic kidney disease (CKD) is an increasingly prevalent disorder that poses a significant global health and socioeconomic burden. East Asian countries such as China, Taiwan, Japan, and South Korea have a higher incidence and prevalence of kidney failure when compared to Western nations, and the reasons for this discrepancy remain unclear. Aldehyde dehydrogenase 2 (ALDH2) is an essential detoxifying enzyme for exogenous and endogenous aldehyde metabolism in mitochondria. Inactivating mutations at E504K and E487K are found in 35-45% of East Asian populations and has been linked to a higher risk of various disorders, including cardiovascular diseases and cancer. However, little is known about the role of ALDH2 in CKD. Here, we characterized the expression pattern of ALDH2 in normal and CKD human and mouse kidneys and demonstrated that ALDH2 expression was significantly reduced, and that the protein level was inversely correlated with the degree of CKD and fibrosis. Further, we treated ALDH2*2 knock-in mice, a loss of ALDH2 function model, with aristolochic acid and found that these mice showed enhanced fibrosis. Moreover, ALDH2 deficiency was associated with kidney fibrosis involving epithelial cell differentiation process in vivo and in vitro. However, ALDH2 overexpression protected proximal tubule epithelial cells from transforming growth factor-β-induced dedifferentiation or partial epithelial-mesenchymal transdifferentiation in vitro. Thus, our findings yield important clinical information regarding the development and progression of CKD involving ALDH2, especially among East Asian populations.

Surgical challenges in Non-combatant Evacuation Operations

BackgroundGlobal uncertainties have prompted nations to adopt vigilant approaches to safeguard their citizens. Recent crises have compelled Western nations to undertake evacuations, ranging from peaceful scenarios to urgent military interventions. In April 2023, Sudan descended into civil war, prompting France to orchestrate a complex evacuation operation leveraging prepositioned forces in Djibouti. Materials & MethodsThis retrospective observational study aims to analyze the surgical challenges encountered during Operation SAGITTAIRE (OS), focusing on human, technical, and logistical requirements for successful military interventions in multinational civilian populations. ResultsOS successfully evacuated 1017 individuals of 84 nationalities from Khartoum using road, sea, and air routes. Special forces teams, including the Surgical Life-saving Module (SLM), were mobilized alongside conventional military elements. The Joint Medical Surgical Center (JMSC) in Djibouti served as a permanent medical facility with comprehensive facilities and staff. Air Medical evacuations were performed for vicitms and surgical interventions were conducted, including damage control surgery, orthopedic procedures, and debridements. Five surgical evaluations and four surgical procedures were performed. The operation spanned 96 hours without death. The SLM, deployed in Khartoum and within an aircraft, played a crucial role. DiscussionOS highlighted the need for a comprehensive health support system. Challenges in assessing health needs led to the establishment of a substantial and adaptable system. The report emphasizes the importance of a comprehensive approach to support Non-combatant Evacuation Operations in French Doctrine. ConclusionOS showcased the French Health Military Service's capabilities in deploying a comprehensive damage control chain in challenging environments. This fatality-free success underlines the effectiveness of coordinated resuscitation, damage control, and transportation. Evacuation operations in non-combatant settings during civil wars pose formidable challenges, requiring a modular and adaptable support concept. Coordination, communication, logistical preparation, and training are crucial elements for successful management of such operations.

The Role of Renewable Energy, Technological Innovation, and Human Capital on Environmental Quality in Türkiye: Testing the LCC Hypothesis with Smooth Structural Shifts

Newly industrializing economies are ardently striving for rapid development, aspiring to emulate the affluence of Western nations. However, amidst this relentless economic dynamism, the world grapples with an escalating climate change crisis. Therefore, it becomes imperative to identify the factors contributing to improving developing nations' environmental quality while concurrently advancing their sustainable development objectives. In this regard, the present study aims to dissect the environmental implications of renewable energy consumption, technological innovation, and human capital and examine the "Load Capacity Curve" (LCC) hypothesis in Türkiye through an extension of the STIRPAT model. To achieve this objective, the research operates a novel econometric methodology, namely the "augmented autoregressive distributed lag" (A-ARDL) approach with Fourier terms, to analyze yearly data from 1980 to 2019. The empirical findings substantiate the validation of the LCC hypothesis in Türkiye, both in the short and long term. Furthermore, the results unveil that renewable energy consumption and human capital significantly bolster ecological welfare over the long term, whereas technological innovation exhibits no discernible impact on the environment. Additionally, the outcomes display that population growth positively impacts the environment in the short term; nevertheless, over the long term, it becomes detrimental to environmental quality.

Security Officials’ Perspectives on Reintegration Challenges for Former Al-Shabaab Foreign Terrorist Fighters in Kenya

ABSTRACT This paper situates the perspectives of selected Kenyan security officials on the reintegration challenges for former foreign terrorist fighters (FTFs) (returnees) affiliated with the AlShabaab. The study reflects on the amnesty intervention program that was launched by the government in 2015 to rehabilitate AlShabaab returnees. This is a situation not unique to Kenya. Since the rise of the Islamic State in Iraq and Syria (post-2015), the dilemma became what states and, more principally, how western nations that had the bulk of foreign fighters would react upon their return from conflict theatres. In the Kenyan context, the rationale at the time was an unconditional surrender and consequently rehabilitation interventions to reintegrate these individuals into society. The Al-Shabaab is an insurgent group based in Somalia that has contributed to insecurity in the Horn of Africa region. This study, relying on a securitization theory lens, reflects on qualitative fieldwork insights with select government security officials in Kenya’s Mombasa and Nairobi Counties. The study probes how these officials frame the security threat that FTFs pose to Kenya, and indeed the region, and consequently their perspectives of reintegration challenges. The study findings present three major frames. The first is their framing of returnees as security threats. The second is their framing of returnees as hampered by legal/policy gaps. The third is their framing around gaps in community acceptance. The findings contribute to the literature on reintegration and offer lucid insights into how such programmatic interventions can be adapted for peacebuilding practice. The findings may be applied in the realm of contextual best practices on what works and does not in reintegration initiatives.

National schools of diplomatic training: divergences in the global epistemology of international relations

The proposition of establishing “global international relations” (Global IR) as an amalgamation of diverse national epistemologies in the field of international relations, potentially superseding the Western-centric paradigm, presents significant challenges. A critical inquiry emerges: Is it possible to form a discipline based on the polyphony of national approaches, despite the fact that the ontology of international relations has remained fundamentally unchanged since the mid-17th century? This study evaluates the thesis of extant national epistemologies in international relations by examining national traditions of diplomatic training. The primary research question is formulated as follows: What are the foundational approaches employed by leading states in the training of IR specialists, and can these approaches be considered reflective of national epistemologies regarding the nature of international relations? The research methodology involves a synthesis of findings from an examination of diplomatic training institutions across a diverse sample of countries. This sample encompasses Western nations (United Kingdom, Hungary, Poland, United States, Finland, France, and Germany), Asian countries (Vietnam, Indonesia, India, China, and the Republic of Korea), Middle Eastern states (Egypt, Iran, Saudi Arabia, and Turkey), African nations (Nigeria and South Africa), and Latin American countries (Brazil, Mexico, and Cuba). The article is structured in two principal sections. The theoretical section explores the hypothesis of “global international relations” within the context of existing literature and theoretical frameworks. The second section synthesizes the empirical findings from the study of national approaches to diplomatic training, testing the hypothesis of its correlation with national epistemologies in the field of international relations.

Comparative Efficacy of 21 Treatment Strategies for Resectable Pancreatic Cancer: A Network Meta-Analysis.

The primary treatment for operable pancreatic cancer (PC) involves surgery followed by adjuvant therapy. Nevertheless, perioperative or neoadjuvant chemotherapy (CT) may be used to mitigate the likelihood of recurrence and mortality. This network meta-analysis (NMA) assesses the comparative efficacy of various treatment approaches for resectable PC. A thorough search was carried out on January 31, 2023, encompassing PubMed/MEDLINE, Cochrane Library, and Embase databases. We incorporated randomized clinical trials (RCTs) that compared surgical interventions with or without (neo)adjuvant or perioperative therapies for operable PC. We conducted a fixed-effects Bayesian NMA. We presented the effect sizes in terms of hazard ratios (HRs) for overall survival (OS) along with 95% credible intervals (95% CrIs). The treatment was deemed statistically superior when the 95% credible interval (CrI) did not encompass a null value (hazard ratio < 1). Treatment rankings were established based on the surface under the cumulative ranking curve (SUCRA). A total of 24 studies were incorporated, comparing 21 treatments with surgery in isolation. Eleven treatments showed superior efficacy compared to surgery alone, with HRs ranging from 0.38 for perioperative treatments to 0.73 for adjuvant 5-fluorouracil. After the exclusion of studies conducted in Asia, it was found that the perioperative regimen of gemcitabine combined with nab-paclitaxel was the most effective regimen (SUCRA, p = 0.99). The findings endorse the utilization of perioperative CT, especially multi-agent CT, as the favored intervention for operable PC in Western nations.

The Evolution of China's Cyber-Espionage Tactics: From Traditional Espionage to AI-Driven Cyber Threats against Critical Infrastructure in the West

Purpose: This article critically investigates the evolution of China’s cyber-espionage strategies, specifically illustrating the shift from traditional espionage methodologies to the incorporation of advanced technologies, particularly artificial intelligence (AI). This transition profoundly reshapes global power dynamics, delineating nuanced threats to critical infrastructure in Western nations, including power grids, financial systems, and communication networks (Wang et al., 2019). Materials and Methods: Utilizing a theoretical framework grounded in Joseph Nye's concept of soft power and contemporary security studies, this research posits a hypothesis: there exists a positive correlation between technological advancements and the escalation of espionage activities by state actors. The inquiry encompasses a comprehensive analysis of key components, such as vulnerabilities, adaptive strategies, geopolitical implications, deterrence mechanisms, and international collaboration, thereby illuminating the multifaceted risks to national security inherent in the digital age (Nye, 2004). Findings: The study critically evaluates the countermeasures undertaken by Western countries, probing strategic enhancements of cyber defences and the formation of international coalitions aimed at collective security (Huang et al., 2021). The findings reveal substantial obstacles in achieving a cohesive and effective response to the rapidly escalating and pervasive nature of contemporary cyber threats (Zhang et al., 2020). Implications to Theory, Practice and Policy: Considering the ongoing maturation of China’s cyber capabilities, characterized by an increased reliance on AI and the impending advent of quantum computing, the article advocates for a comprehensive revaluation of global security practices (Mann et al., 2020). It underscores the imperative for Western nations to not only innovate defensively but to also adopt proactive measures and foster significant international collaboration. This multifaceted approach is essential to address the complex challenges posed by state-sponsored cyber operations within an increasingly interconnected global landscape (Chen et al., 2021).

Obesity, Metabolic Syndrome, and Sugar-Sweetened Beverages (SSBs) in America: A Novel Bioethical Argument for a Radical Public Health Proposal.

The prevalence of obesity, metabolic syndrome, and the associated long-term chronic diseases (cardiovascular disease, type II diabetes, cancer, Alzheimer's disease, depression) have reached epidemic levels in the United States and Western nations. In response to this public health calamity, the author of this paper presents and defends a novel bioethical argument: the consistency argument for outlawing SSBs (sugar-sweetened beverages) for child consumption (the "consistency argument"). This argument's radical conclusion states that the government is justified in outlawing SSBs consumption for child consumption. The reasoning is as follows: if one accepts that the physical harm caused by chronic alcohol consumption justifies the government outlawing alcoholic beverages for child consumption, and there is strong evidence that comparable physical harms result from chronic SSBs consumption, then, mutatis mutandis, the government is also justified in outlawing child consumption of SSBs. To support this argument, the author provides extensive evidence based on epidemiological observational studies, interventional studies, controlled trials, large meta-analyses, and the pathophysiology and biological mechanisms of action behind SSBs and chronic disease. Chronic consumption of large doses of SSBs and alcoholic beverages both drive the same diseases: obesity and insulin resistance, cardiovascular disease, hypertension, and cancer. Chronic SSB consumption carries the additional risk of Alzheimer's disease, dementia, and depression. The author concludes this paper by considering prominent objections to the consistency argument, and then demonstrating that each objection is unsound.