West Africa Research Articles

Sensitivity of global hydrological models to potential evapotranspiration estimation methods in the Senegal River Basin (West Africa)

Study regionSenegal River Basin in West Africa Study focusThis paper aims to evaluate the sensitivity of global hydrological models to potential evapotranspiration (PET) methods in the Senegal River Basin. Potential evapotranspiration is estimated using 21 methods and its influence on the performance of three GR models (GR4J, GR5J and GR6J) is investigated in five catchments. The data used are mean rainfall, discharge and observed and calculated PET over the period 1984-1995. PET is calculated based on observed climate data and those from NASA POWER reanalysis data. The methodology consists in: (i) comparing the consistency of reanalysis data with respect to the observed PET, (ii) assessing the robustness of GR models and their sensitivity to different PET estimation methods. The evaluation criteria used to assess the performance of the hydrological model are KGE and PBIAS. New hydrological insights for the regionGood consistency is obtained between PET calculated with observed and reanalysis data. The GR4J and GR5J are more efficient to simulate flows in the Senegal River sub-basins. The aerodynamic PET methods perform well with the three hydrological models. However, in this context where data are scarce, temperature methods such as Droogers and Allen are a good choice for hydrological modeling. The results also show that the GR models have the ability to adapt to poorly estimated PET.

Prevalence and disparities in adolescents’ sedentary behavior from twenty-three African countries: evidence from World Health Organization Global School-based Student Health Survey

ObjectivesStudies on sedentary behavior among adolescents in Africa are limited, hindering public health initiatives. The aim of this study was to examine the prevalence, age, gender, country's income level, and sub-regional disparities of sedentary behavior among adolescents in Africa. Study designCross sectional. MethodsAdolescents who participated in the Global School-based Student Health Survey from the 23 participating African countries were included in the study. Sedentary behavior was assessed with a self-reported questionnaire. A meta-analysis using random effect modeling was used to estimate the prevalence, age, gender, country's income level, and sub-regional disparities of sedentary behavior. ResultsSixty three thousand six hundred thirty five adolescents (12–17 years) were included in the analysis. The prevalence of sedentary behavior was 30% (95% CI: 27%–34%) and significantly higher among adolescents in Southern Africa and East Africa compared to adolescents in West Africa and North Africa (Q = 25.15; P < 0.001). No disparities were found for age (Q =1.51; P = 0.22), gender (Q = 0.10; P = 0.75), country's income level (Q = 4.37; P = 0.11), and survey year (Q = 1.03; P = 0.31). The results were heterogeneous between countries. ConclusionsThe results suggest that a significant proportion of adolescents in Africa engage in sedentary behavior, with the highest prevalence found in Southern Africa and East Africa. This highlights the need for context-specific policy design and interventions to increase physical activity engagement and limit sedentary behavior among adolescents in Africa.

A computational discovery of hexokinase 2 inhibitors from Newbouldia laevis for Hepatocellular carcinoma (HCC) treatment

Newbouldia laevis, also known as the African Border Tree or Fever Tree, is a deciduous tree native to West Africa. The plant is valued for its medicinal properties and is used in traditional medicine for its antimicrobial and anti-inflammatory effects. N. laevis, is a storage tank of phytochemicals with huge health benefits and performances globally for the treatment and management of numerous disease conditions. Limited research exists on the usage of N. laevis for hepatocellular carcinoma (HCC) treatment. This study aims to explore the inhibitory activities of phytochemicals from N. laevis against the hexokinase 2 protein, a target in hepatocarcinoma (HCC) treatment. This study presents a unique in silico approach that includes ligand binding site prediction, molecular docking, molecular dynamics simulation, and Molecular Mechanics Poisson–Boltzmann Surface Area (MM/PBSA) methods. A total of 35 phytochemicals with available 3D structures were identified through literature mining. The literature review highlighted the significance of hexokinase 2 protein as a target inhibitor in the treatment of hepatocellular carcinoma (HCC). Molecular docking experiment with the all the identified phytochemicals and hexokinase 2 revealed that all the identified phytochemicals had potential inhibitory activities against the target protein. Moreover, chrysarobin, apigenin and ursolic acid were the best inhibitors with lowest binding energy of −8.9 kcal/mol, −8.7 kcal/mol, and −8.5 kcal/mol, respectively. The docking experiment was validated by comparing the binding affinities with known reference drug Cabozantinib-S-malate (−8.3 kcal/mol). Further, molecular dynamics studies of complexes with the best docking scores and reference drug complexes were described in detail here. The results of 100 ns modeling (RMSD, RMSF, Rg and SASA) show extraordinary stability during the establishment of complexes with apigenin and ursolic acid, as well as favorable binding energy, which was determined theoretically by means of the MM/PBSA method, thereby increase the probability of their acting as promising and likely hexokinase 2 inhibitors. Therefore, the study predicted that apigenin and ursolic acid could be used as a potential inhibitor/antagonist for the hexokinase 2 enzyme.

Apport du scanner cardiaque dans la prise en charge des cardiopathies congénitales : expérience de l'institut de cardiologie d'Abidjan à propos de 27 cas

Introduction and objectivesIn contrast to developed countries, cardiac CT is not widely used in West Africa for the assessment of congenital heart disease, and has only recently been introduced in Côte d'Ivoire. The lack of data prompted this study, the aim of which was to describe our experience of the contribution of CT to the management of congenital heart disease in the Ivorian cardiology setting. Patients and methodThis was a prospective study which took place in the pediatric cardiology department over a period of 9 months (September 2022 to June 2023) which included all patients with congenital heart disease explored by echocardiography and cardiac scan. ResultsThe average age was 5.7 ± 4.7 years with extremes of 5 months and 16 years. We noted a female predominance with a sex ratio of 0.52. The main heart diseases were: tetralogy of Fallot (37.1%), followed by pulmonary atresia with open septum (18.52%). The assessment of the anatomy of the pulmonary arteries (81.48%), the search for aortopulmonary collaterals (59.63%) and finally the assessment of the anatomy of the aorta (18.52%) were the main indications. The practice of cardiac CT scanning has enabled better accuracy in the diagnosis and management of congenital heart disease in several cases: an interruption of the aortic arch was found in 1 case initially suspected of hypoplasia of the aortic arch, three cases of partial abnormal pulmonary venous return and one case of total abnormal pulmonary venous return. Also, agenesis of the left pulmonary artery with birth anomaly of the right coronary artery in the assessment of tetralogy of Fallot was found in 1 case. The CT scan made it possible to specify the exact topography of the aortopulmonary collaterals in four cases of pulmonary atresia with an open septum. ConclusionCT has enabled better visualization of the arterial and venous pulmonary tree, identification and exact localization of aorto-pulmonary collaterals, precise description of the three-dimensional anatomy of the coronary arteries, and better precision of congenital anomalies of the aorta.

Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry.

Lassa virus (LASV) is the causative agent of human Lassa fever which in severe cases manifests as hemorrhagic fever leading to thousands of deaths annually. However, no approved vaccines or antiviral drugs are currently available. Recently, we screened approximately 2,500 compounds using a recombinant vesicular stomatitis virus (VSV) expressing LASV glycoprotein GP (VSV-LASVGP) and identified a P-glycoprotein inhibitor as a potential LASV entry inhibitor. Here, we show that another identified candidate, hexestrol (HES), an estrogen receptor agonist, is also a LASV entry inhibitor. HES inhibited VSV-LASVGP replication with a 50% inhibitory concentration (IC50) of 0.63 µM. Importantly, HES also inhibited authentic LASV replication with IC50 values of 0.31 µM-0.61 µM. Time-of-addition and cell-based membrane fusion assays suggested that HES inhibits the membrane fusion step during virus entry. Alternative estrogen receptor agonists did not inhibit VSV-LASVGP replication, suggesting that the estrogen receptor itself is unlikely to be involved in the antiviral activity of HES. Generation of a HES-resistant mutant revealed that the phenylalanine at amino acid position 446 (F446) of LASVGP, which is located in the transmembrane region, conferred resistance to HES. Although mutation of F446 enhanced the membrane fusion activity of LASVGP, it exhibited reduced VSV-LASVGP replication, most likely due to the instability of the pre-fusion state of LASVGP. Collectively, our results demonstrated that HES is a promising anti-LASV drug that acts by inhibiting the membrane fusion step of LASV entry. This study also highlights the importance of the LASVGP transmembrane region as a target for anti-LASV drugs.IMPORTANCELassa virus (LASV), the causative agent of Lassa fever, is the most devastating mammarenavirus with respect to its impact on public health in West Africa. However, no approved antiviral drugs or vaccines are currently available. Here, we identified hexestrol (HES), an estrogen receptor agonist, as the potential antiviral candidate drug. We showed that the estrogen receptor itself is not involved in the antiviral activity. HES directly bound to LASVGP and blocked membrane fusion, thereby inhibiting LASV infection. Through the generation of a HES-resistant virus, we found that phenylalanine at position 446 (F446) within the LASVGP transmembrane region plays a crucial role in the antiviral activity of HES. The mutation at F446 caused reduced virus replication, likely due to the instability of the pre-fusion state of LASVGP. These findings highlight the potential of HES as a promising candidate for the development of antiviral compounds targeting LASV.

Birth weight mediates the association of maternal undernutrition with child undernutrition prevalence in West Africa.

Maternal nutritional status before and during pregnancy is an important determinant of foetal health. In West Africa, maternal and child undernutrition remains a major public health problem and it is important to establish the mechanistic pathway linking the two disorders to help address the problem. We therefore assessed the mediating role of low birth weight (LBW) in the relationship of maternal undernutrition with child undernutrition in West Africa. We included recent (2010-2019) DHS data from thirteen West African countries. Poisson regression model with robust standard errors was used to assess the relationship between maternal undernutrition (body mass index and anaemia) and child undernutrition (stunting, wasting, underweight, and anaemia). Structural equation modelling was used to conduct the mediation analysis. Prevalence of stunting, wasting, underweight, and anaemia among under-five children in West Africa was found to be 32.4%, 8.1%, 20.1%, and 71.5%, respectively. We found children of underweight mothers to be more likely to be undernourished (stunted, wasted, and underweight) and anaemic compared to children of normal-weight mothers. Also, children of anaemic mothers were more likely to be stunted and anaemic but not wasted compared with children of non-anaemic mothers. LBW mediated the observed relationships between maternal BMI and childhood stunting (22.6%), and maternal anaemia and childhood stunting (24.9%), wasting (11.7), and anaemia (6.6%). We found maternal undernutrition to be associated with child undernutrition in West Africa with LBW noted to be a mediator of the observed relationship. We recommend that, to address the child undernutrition problem in West Africa, governments and policymakers must integrate measures to address the burden of LBW.

5 - Recalibrating the labyrinths of migration and health in West Africa

The discourses and practices surrounding migration and health have taken a dramatic turn since the outbreak of the Covid-19 pandemic. Experts are more concerned about the consequences of the pandemic on these factors in Africa, given the continent’s weak economies and poor health sector, which portends a difficult post-pandemic recovery. However, the discussions have not engaged with two key effects of the coronavirus: the health implications not only on the general populace but also along border towns, and the dilemma of a ‘new’ (il)legal migration. Drawing on Ghana’s border policing as a Covid-19 pandemic governance strategy, coupled with existing debates on health, politics, migration and development, we argue that border policing is likely to create two emerging threats. First, it could cause a ‘new’ health dilemma – hindering long-standing cross-border healthcare access by ECOWAS citizens. Second, sustained border restrictions could deepen the intricacies of migration in West Africa, including the promotion of ‘elite migrants’ over migrants who are seeking a basic livelihood, the changing fate of undocumented migrants, new security threats at border town , and a possible redefinition of traditional rural–urban migration in Africa.

The benefits of HIV self-testing in West Africa: quantified.

The benefits of HIV self-testing in West Africa: quantified.

Constraints on Strawberry (Fragoria vesca) Production in Burkina Faso and Benin: A Review

Horticulture represents an important part of the agricultural economy in Burkina and Benin. Strawberry growing is a main activity for many producers. Strawberries are a high value-added product. This analytical review aims to summarize the work carried out on strawberries in order to define research perspectives for a better understanding of the constraints of its production. This review is produced from documentation focused on the relevance of the articles. The identified diseases and pests as the major constraints that can cause losses of up to 100% of production. Burkina is one of the major strawberry producers in West Africa unlike Benin where there are small farms in the North. A research perspective based on major constraints would make it possible to boost strawberry production and ensure better productivity.

A novel indicator in epidemic monitoring through a case study of Ebola in West Africa (2014-2016).

The E/S (exposed/susceptible) ratio is analyzed in the SEIR model. The ratio plays a key role in understanding epidemic dynamics during the 2014-2016 Ebola outbreak in Sierra Leone and Guinea. The maximum value of the ratio occurs immediately before or after the time-dependent reproduction number (Rt) equals 1, depending on the initial susceptible population (S(0)). It is demonstrated that transmission rate curves corresponding to various incubation periods intersect at a single point referred to as the Cross Point (CP). At this point, the E/S ratio reaches an extremum, signifying a critical shift in transmission dynamics and aligning with the time when Rt approaches 1. By plotting transmission rate curves, β(t), for any two arbitrary incubation periods and tracking their intersections, we can trace CP over time. CP serves as an indicator of epidemic status, especially when Rt is close to 1. It provides a practical means of monitoring epidemics without prior knowledge of the incubation period. Through a case study, we estimate the transmission rate and reproduction number, identifying CP and Rt = 1 while examining the E/S ratio across various values of S(0).

Variabilities and trends in the onset, peak, and retreat of Intertropical Discontinuity (ITD) annual migrations over West Africa between 1979 and 2020

Variabilities and trends in the onset, peak, and retreat of Intertropical Discontinuity (ITD) annual migrations over West Africa between 1979 and 2020

Spatio-temporal Trends and Patterns of Synthetic Fertility Index Across African Countries: A Comprehensive Analysis from 1950 to 2023

This paper examines the spatiotemporal trends and patterns of the Synthetic Fertility Index (SFI) in African countries from 1950 to 2023. The study used data from the Demographic and Health Surveys (DHS) program and Atlasocio.com to analyse the evolution of fertility rates in Africa. The findings reveal a significant decline in fertility rates over the past decades, with many countries experiencing a shift from high SFI exceeding 6 children per woman in the mid-20th century to levels below 3 children per woman by 2023. However, regional disparities persist, with North African countries and South Africa consistently demonstrating lower SFIs compared to their counterparts in West Africa, Central Africa, and East Africa. The study emphasizes the importance of addressing persistent regional disparities in fertility rates through targeted policies and interventions aimed at improving access to education and healthcare, promoting gender equality, and addressing cultural norms and practices that perpetuate high fertility rates. Overall, the study provides valuable insights into the demographic transition taking place in Africa and highlights the need for continued research and policy action to promote socio-economic development in the continent

Gender and endogenous knowledge inclusion for agroforestry systems improvement in Benin, West Africa

AbstractIn West Africa, and Benin particularly, local forest resources can potentially contribute to both increasing and stabilizing soil productivity. However, these resources continue to be neglected with efforts instead concentrated on promoting exotic species. This study aimed to prioritize local agroforestry species on agricultural landscape by investigating the gendered, socio-demographic and agro-pedological factors of local knowledge and use of agroforestry species amongst small-holder farmers in Benin. An agroforestry inventory combined with an ethno-agroforestry survey was conducted on 364 farms with 364 farmers. A cluster analysis based on farmers' socio-demographic and agroecological factors was used to cluster farmers into two homogeneous agroforestry systems. Median score, species diversity and ecological networks were established for these two systems. Results illustrate that gendered difference exist between the priority that farmers give to multi-purpose species and this prioritization depends on priority ecosystem services for farmers and gender. Therefore, it would be useful first to consider gender and specific needs of each category of farmer to optimize the choice of agroforestry species to be promoted in such systems. The successful introduction of identified species through extension programs requires more advanced research related to the real contribution of these species to farmland fertilization, as well as the nutrient transmission pathways to associated crops in an agroforestry system to address simultaneously specific ecological, economic and socio-cultural sustainability criteria, as well as improved crop production.

Critically Small Contemporaneous Effective Population Sizes Estimated for Stocks of the African Bonytongue in Western Africa

Critically Small Contemporaneous Effective Population Sizes Estimated for Stocks of the African Bonytongue in Western Africa

Global potential distributions and conservation status of rice wild relatives

Societal Impact StatementRice wild relatives (RWR) provide valuable genetic resources for modern rice breeding, yet knowledge gaps constrain their conservation and further utilization. To address these gaps, the potential distributions of 22 RWR taxa were modeled, and their conservation statuses were assessed. Most taxa were identified as medium priority for further conservation. Further ex‐situ collecting hotspots are in Southeast and South Asia, Northern Australia, West Africa, and tropical Americas, while habitat protection lies in Southeast and South Asia, Northern Australia, and West Africa. Climate change may shift equatorial habitats to higher latitudes and mountain habitats to higher altitudes.Summary Rice wild relatives (RWR) provide valuable genetic resources for modern rice breeding. However, knowledge gaps on their geographic distributions and conservation status constrain their conservation and further utilization. To fill these critical gaps, we modeled the potential distributions of 22 RWR taxa under current climate scenarios, assessed their conservation status, both ex situ (in genebanks or botanical gardens) and in situ (in protected areas), and examined changes in taxa richness of RWR in predicted areas under future climate scenarios. The RWR were primarily distributed in tropical Asia to tropical Australia, tropical Africa, and South and Central America. We identified 4 out of 22 taxa as high priority (HP) for further conservation action and 18 taxa as medium priority (MP). Hotspots requiring further collecting for ex situ conservation are concentrated in Southeast and South Asia, Northern Australia, West Africa, and tropical Americas. Meanwhile, habitat protection should be enhanced in Southeast and South Asia, Northern Australia, and West Africa. Under future climate change, suitable habitats near the equator are expected to shift toward higher latitudes and some in lower‐latitude basins may become unsuitable due to excessive heat, resulting in decreased taxa richness in these areas. Additionally, suitable habitats in high mountain areas may shift to higher altitudes, potentially augmenting taxa richness in the highlands. Our findings provide vital insights to guide future rescue conservation efforts for RWR.

Livestock feed resources used as alternatives during feed shortages and their impact on the environment and ruminant performance in West Africa: a systematic review

Ruminant feed is a major problem for the livestock sector in West African developing countries causing animal nutritional diseases, reducing ruminant production, and creating a massive ecological crisis through greenhouse gas emissions. Alternative feeds, which include agro-industrial by-products, fodder trees, crop residues, insects, fodder legumes, algae, and pulses, constitute enormous feed resources for livestock in Africa. This study was conducted in accordance with the methodological recommendations of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We conducted a literature search using Google Scholar, Web of Science, and Scopus to identify documents related to alternative ruminant feeds using the following keywords: alternative feeds, ruminant products, environmental impacts, and West Africa. Those that met the inclusion criteria were included, resulting in 44 articles published between 2013 and 2023. These studies included 45 alternative feeds divided into six groups, including agro-industrial by-products (48.89%), followed by fodder trees (17.78%), crop residues (13.33%), insects (8.89%), fodder legumes (6.67%) and seaweeds (4.44%). Our results revealed that alternative feed resources and their effects on ruminant’s performances and environment are poorly known in West Africa, which limits their inclusion in rations and sometimes leads to their misuse. Future research should focus on these aspects in order to make efficient use of these resources to improve ruminant milk and meat production.

Contribution of Therapeutic Foods to the Nutritional Care of Malnourished Children in West Africa

Contribution of Therapeutic Foods to the Nutritional Care of Malnourished Children in West Africa

Ferric iron in eclogitic garnet and clinopyroxene from the V. Grib kimberlite pipe (NW Russia): evidence of a highly oxidized subducted slab

Abstract Estimates of oxygen fugacity of eclogitic rocks are linked to the redox evolution of the oceanic protolith during subduction and its residence in the lithospheric mantle, and, based on knowledge of pressures and temperatures, allow modelling of the speciation of volatile elements and diamond (or graphite) versus carbonate stability. To date, the oxygen fugacity of mantle eclogites has been shown to vary between -6 (Kasai, Congo and Udachnaya, Siberia) and -0.1 (Udachnaya, Siberia) log units (relative to the fayalite-magnetite-quartz buffer, FMQ), linked to the low Fe3+ contents of garnets. In this study we investigated the Fe oxidation state of coexisting garnet and clinopyroxene hand-picked out of 17 diamond-free high-MgO and low-MgO mantle eclogites (dated at 2.84 Ga) from the V. Grib kimberlite pipe (East-European platform). Measured Fe3+/∑Fe values range between 0.03 and 0.19 for garnet and 0.18 to 0.38 for clinopyroxene, the former being higher than what was measured previously in garnets equilibrated at mantle conditions. The Fe3+/∑Fe of the reconstructed bulk rock ranges between 0.10 and 0.15 for high-MgO eclogites and 0.10 and 0.24 for low-MgO eclogites (with uncertainties of ± 0.02 and ± 0.03 in both cases). Thermobarometric calculations result in equilibration pressures and temperatures of 3.0 - 5.2 (± 0.4) GPa and 720 - 1050 (± 60) °C for both high-MgO and low-MgO eclogites, slightly lower than previous P-T estimates of mantle eclogites from the Udachnaya kimberlite pipe (Siberian craton). At these conditions, ∆logfo2 (FMQ) calculated using the available oxythermobarometric model varies from -1.7 to -0.6 log units for high-MgO eclogites and from -2.9 to 0.9 log units for low-MgO eclogites. Samples recording ∆logfo2 (FMQ) ≤ -1 log units overlap with North Slave, West Africa and Udachnaya eclogites, with no difference among eclogite types. The average values of -1.2 (± 0.4) log units for high-MgO and -0.6 (± 1.1) log units for low-MgO eclogites suggest different redox conditions of basaltic protoliths during subduction worldwide. Previous geochemical studies on the same rock samples reported evidence of cryptic metasomatism in both garnet and clinopyroxene that we demonstrate being not recorded by their major elements, while modal metasomatism evidenced by the presence of phlogopite as a product of interaction with a kimberlitic melt only affects the MgO of the bulk rock. Therefore, we suggest that high Fe3+/∑Fe ratios for garnet (&amp;gt; 0.10) and for reconstructed bulk rocks in the case of both low-MgO and high-MgO samples cannot be due to metasomatic interaction with an oxidized fluid, but rather are the consequence of Fe3+ redistribution in an unusually oxidized mafic protolith upon metamorphism. Our results highlight the redox variability of eclogites of Archaean age at conditions more oxidized than present-day MORBs and imply an oxidizing nature of the convective mantle source where magma was formed with consequent speciation of C in the form of carbonate fluid explaining, therefore, the lack of diamonds in V. Grib kimberlite pipe.

Whole-genome resequencing reveals genomic variation and dynamics in Ethiopian indigenous goats

Ethiopia has about 52 million indigenous goats with marked phenotypic variability, which is the outcome of natural and artificial selection. Here, we obtained whole-genome sequence data of three Ethiopian indigenous goat populations (Arab, Fellata, and Oromo) from northwestern Ethiopia and analyzed their genome-wide genetic diversity, population structure, and signatures of selection. We included genotype data from four other Ethiopian goat populations (Abergelle, Keffa, Gumuz, and Woyto-Guji) and goats from Asia; Europe; and eastern, southern, western, and northern Africa to investigate the genetic predisposition of the three Ethiopian populations and performed comparative genomic analysis. Genetic diversity analysis showed that Fellata goats exhibited the lowest heterozygosity values (Ho = 0.288 ± 0.005 and He = 0.334 ± 0.0001). The highest values were observed in Arab goats (Ho = 0.310 ± 0.010 and He = 0.347 ± 4.35e−05). A higher inbreeding coefficient (FROH = 0.137 ± 0.016) was recorded for Fellata goats than the 0.105 ± 0.030 recorded for Arab and the 0.112 ± 0.034 recorded for Oromo goats. This indicates that the Fellata goat population should be prioritized in future conservation activities. The three goat populations showed the majority (∼63%) of runs of homozygosity in the shorter (100–150 Kb) length category, illustrating ancient inbreeding and/or small founder effects. Population relationship and structure analysis separated the Ethiopian indigenous goats into two distinct genetic clusters lacking phylogeographic structure. Arab, Fellata, Oromo, Abergelle, and Keffa represented one genetic cluster. Gumuz and Woyto-Guji formed a separate cluster and shared a common genetic background with the Kenyan Boran goat. Genome-wide selection signature analysis identified nine strongest regions spanning 163 genes influencing adaptation to arid and semi-arid environments (HOXC12, HOXC13, HOXC4, HOXC6, and HOXC9, MAPK8IP2), immune response (IL18, TYK2, ICAM3, ADGRG1, and ADGRG3), and production and reproduction (RARG and DNMT1). Our results provide insights into a thorough understanding of genetic architecture underlying selection signatures in Ethiopian indigenous goats in a semi-arid tropical environment and deliver valuable information for goat genetic improvement, conservation strategy, genome-wide association study, and marker-assisted breeding.

Predicting the dynamics of per- and polyfluoroalkyl substances in coastal regions of Africa: vulnerability index and adverse ecological pathways from remote-sensed variables.

This study aimed to predict the dynamics of per- and polyfluoroalkyl substance (PFAS) contamination and ecological vulnerability within coastal regions of Africa utilizing time-averaged remote-sensed data patterns from 2020 to 2023. The analysis identified PFAS contamination hotspots along the coast of Africa, particularly in western Africa around Nigeria and in areas spanning Equatorial Guinea and Guinea-Bissau, with risk influenced by eastward wind patterns, overland runoff, and elevated aerosol optical depth (AOD) values. Regional trends indicated that variations in solar energy absorption and surface air temperature could influence PFAS dynamics in North Africa, South Africa, East Africa, and West Africa. In North Africa, intermediate overland runoff and lower sea-surface temperatures were observed. In South Africa, there were intermediate runoff levels and warmer sea-surface temperatures. East Africa experienced intermediate runoff as well. In West Africa, there was increased susceptibility to high overland runoff and aerosol-related PFAS contamination. From the weighted vulnerability index, significant disparities in environmental conditions across African coastal regions revealed that North Africa had relatively lower vulnerability, while West Africa had the highest susceptibility to per- and polyfluoroalkyl substance (PFAS) contamination. This study emphasizes the necessity for region-specific vulnerability index models and targeted mitigation strategies to address diverse ecological and health risks from PFAS contamination along the African coast. Regional and international collaboration, spearheaded by organizations such as the AU and ECOWAS, is essential, with tailored policies aligned with the SDGs, Agenda 2063, and NEPAD crucial for effective environmental management, urging policymakers to prioritize cooperation and resource sharing for comprehensive sustainability goals.