The modern Tianshan Mountains and their surrounding basins have mainly been shaped by the far field effects of the Cenozoic India-Asia collision. However, precollision topographic evolution of the Tianshan Mountains and its impacts on the Junggar and Turpan Basins remain unclear due to the scarcity of data. Detrital zircon U-Pb dating of 14 new and 23 published samples from Permian to Neogene strata in the northern Western Tianshan Mountains, northern and southern Bogda Mountains and Central Turpan Basin, are combined with sedimentary characteristics (lithofacies, petrofacies and paleocurrent data) to investigate the temporal and spatial changes in sediment provenances. Based on the age characteristics of the source rocks in the Tianshan Mountains, the detrital zircons are divided into three groups: pre-Carboniferous zircons, mainly from the Central Tianshan Mountains; Carboniferous to Permian zircons, mainly from the North Tianshan and Bogda Mountains; and Mesozoic zircons, mainly from syn-depositional volcanic activity. The topographic evolution of the Tianshan Mountains and their relation to the Junggar and Turpan Basins can be generally divided into six stages. (1) Positive-relief Tianshan and Bogda Mountains and a rifted marine basin formed during the Early Permian to early Middle Permian following late Carboniferous orogenesis, as evidenced by interbedded alluvial fan conglomerates and postcollisional extension-related volcanic rocks along the basin margins, by marine deposits far from the basin margins and by the predominance of Carboniferous to Permian detrital zircons. (2) Fluvial to lacustrine deposits in the modern southern Junggar and Turpan Basins are characterized by abundant pre-Carboniferous zircons and consistently northward-flowing paleocurrents, indicating the submergence of the Bogda Mountains and a contiguous Junggar-Turpan continental depression basin during the late Middle Permian to the Triassic. (3) The Bogda Mountains began to uplift in the Early Jurassic, resulting in opposing paleocurrent directions, a sudden increase in sedimentary lithic detritus and the dominance of Carboniferous to Permian detrital zircons along the southern and northern margins of this range. (4) In contrast to the uplift of the Bogda Mountains, the other parts of the Tianshan Mountains experienced gradual peneplanation from the Early Jurassic to the Middle Jurassic, as confirmed by widespread fluvial to lacustrine deposits, even inside the modern Tianshan Mountains, and by the dominance of pre-Carboniferous detrital zircons. (5) The dominance of Carboniferous to Permian zircons in the southern Junggar Basin suggests the West Tianshan Mountains were uplifted during the Late Jurassic, while the dominance of pre-Carboniferous zircons in the Central Turpan Basin indicates continuous peneplanation in the Eastern Tianshan Mountains. (6) The initial shape of the Tianshan Mountains-Junggar Basin-Turpan Basin system was constructed in the Late Jurassic but was modified in the Cenozoic by the India-Asia collision, resulting in much higher Western Tianshan and Bogda Mountains, low Eastern Tianshan Mountains and well-developed foreland basins. These Cenozoic changes were recorded by the rapid cooling of apatites, the dominance of Carboniferous to Permian zircons in the southern Junggar Basin and northern Turpan Basin, and the dominance of pre-Carboniferous zircons in the Central Turpan Basin.