Abstract Using west-central Sardinia as a case study, this article explores how multi-scalar survey archaeology can be used to address questions of the intensity, nature, and scale of interaction in the Iron Age central Mediterranean. This large island played an important role in Mediterranean trade networks and was frequented and settled by Phoenicians, Carthaginians, and Romans, among others over the course of the first millennium BCE. These foreign groups interacted with local Nuragic people through trade, the exchange of ideas, and genetic admixing, which led to increasing connectivity over time. Large excavations at major colonial sites and genetic studies have reinforced the perception that interactions were felt most strongly in coastal regions, while inland communities remained more isolated. Our multi-scalar survey data, drawn from site-based survey at the inland nuraghe S’Urachi and regional survey in its surrounding territory (the Sinis Archaeological Project), supply information concerning how Iron Age interactions impacted inland rural communities. These data show how interaction transformed over time, as trade increased and agriculture intensified in response to external demands. Ultimately, we suggest that survey archaeology is an important tool for illuminating multi-scalar interaction in Sardinia and elsewhere.