SUMMARY This study analysed seismicity in southwestern China (1 January 2008 to 30 June 2021) using the earthquake catalogue compiled by the China Earthquake Network Center and four different space–time Epidemic-Type Aftershock Sequence models: the 2-D point-source (PS) model, the 2-D finite-source (FS) model, the 3-D PS model and the 3-D FS model. Our objective was to understand the features of the background seismicity and the patterns of earthquake clusters to better evaluate the regional seismic hazard. We carefully investigated the aftershock sequences that followed 7 of the 10 MS ≥ 6.0 earthquakes that have struck this region since the occurrence of the 2008 Wenchuan MS 8.0 earthquake [i.e. the Panzhihua (31 August 2008; MS 6.0), Yaoan (9 July 2009; MS 6.0), Lushan (20 April 2013; MS 7.0), Ludian (3 August 2014; MS 6.5), Jinggu (7 October 2014; MS 6.6), Kangding (11 November 2014; MS 6.3) and Yangbi (21 May 2021; MS 6.4) earthquakes]. Our results revealed the following. (1) The background seismicity level for natural earthquakes is usually stable but can experience sudden change due to major events, such as the 2014 Ludian MS 6.5, and the 2014 Jinggu MS 6.6 events. Such changes in the background rate can reach 50 per cent. (2) Reservoir-induced earthquakes substantially increase the level of regional seismicity, indicating that they cannot be ignored when analysing natural seismicity and evaluating regional earthquake hazards. (3) Events triggered directly by the main shock occur mostly in regions adjacent to areas with large coseismic slip, showing a pattern complementary to the main shock ruptures.