Biofilm formation and growth is a significant concern for water treatment professionals, as it can lead to the contamination of water systems and pose a threat to public health. Biofilms are complex communities of microorganisms that adhere to surfaces and are embedded in an extracellular matrix of polysaccharides and proteins. They are notoriously difficult to control, as they provide a protective environment for bacteria, viruses, and other harmful organisms to grow and proliferate. This review article highlights some of the factors that favor biofilm growth, as well as various strategies for controlling biofilm in water systems. Adopting the best available technologies, such as wellhead protection programs, proper industrial cooling water system maintenance, and filtration and disinfection, can prevent the formation and growth of biofilms in water systems. A comprehensive and multifaceted approach to biofilm control can reduce the occurrence of biofilms and ensure the delivery of high-quality water to the industrial process.