Well-being In Adult Patients Research Articles

The use of medicinal marijuana for treating Cerebral Palsy: a literature review

Background Recent studies have established that Medicinal Marijuana (MM) is beneficial in the treatment of spasms, sleep, and pain in adult patients with varying medical diagnoses and symptoms. However, MM has rarely been used for the treatment of Cerebral Palsy (CP) complications in adults. The aim of this systematic literature review was to explore MM interventions globally, with a focus on identifying the best practice with MM for the treatment of complications of CP. Methods A systematic literature search was performed using keywords and synonyms related to MM treatment and CP complications. Inclusions and exclusions were scoped to scholarly peer reviewed academic literature published 2019 to 2021 located in the Deakin Library collection. A screening process confirmed criteria adherence and identified additional papers in referencing. The papers were appraised and evaluated to ensure selections do not have perceived or actual bias. Results From 409 publications, 27 papers were selected for review because they investigated the benefits of MM treatment for patients with sleep, pain, and spasm complications. There was no literature found on the use of MM for adults with CP. Discussion Recent research has demonstrated that with an informed understanding of MM treatment adult patients with varying medical diagnoses and symptoms can use MM to manage sleep disruption and improve relaxation. Therefore, there are potential benefits for the use of MM in treating spasticity, pain, sleep, quality of life, and social and emotional wellbeing in adult patients with CP. No funding was sort or provided for this review and the results are specific to adults with CP, so they are not to be generalized to other populations.

Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease.

Congenital heart disease (CHD) represents a significant risk factor with profound implications for neonatal survival rates and the overall well-being of adult patients. The emergence of induced pluripotent stem cells (iPSCs) and their derived cells, combined with CRISPR technology, high-throughput experimental techniques, and organoid technology, which are better suited to contemporary research demands, offer new possibilities for treating CHD. Prior investigations have indicated that the paracrine effect of exosomes may hold potential solutions for therapeutic intervention. This review provides a summary of the advancements in iPSC-based models and clinical trials associated with CHD while elucidating potential therapeutic mechanisms and delineating clinical constraints pertinent to iPSC-based therapy, thereby offering valuable insights for further deliberation.

Self-disclosure in Adult Patients With Cancer: Structural Equation Modeling.

Health-related self-disclosure has been studied in various aspects, as has self-disclosure of cancer patients. However, any theoretical models that comprehensively include self-disclosure events, factors associated with self-disclosure, and the outcomes of self-disclosure of cancer patients have not yet been presented. The purpose of this study was to explore the relationships between self-disclosure, perception toward cancer, intention for self-disclosure, level and range of self-disclosure, social support, and well-being in adult patients with cancer. Data were collected from adult cancer patients via an online survey using self-report questionnaires and analyzed using structural equation modeling. The data from 359 participants were included in the final analysis. Positive intention for self-disclosure was a significant predictor of both self-disclosure level and range, whereas negative perception toward cancer significantly decreased self-disclosure level. The self-disclosure level significantly improved both social support and well-being, whereas the self-disclosure range did not present a significant impact on social support and well-being. Self-disclosure is closely associated with social support and well-being, and self-disclosure can be promoted by improving negative perceptions and positive intentions about self-disclosure. In addition, to improve the social support and well-being of cancer patients, it suggests increasing the self-disclosure depth level rather than widening the range of self-disclosure. The results of this study can be used as evidence for the development of nursing intervention programs to reduce negative perceptions toward cancer and improve positive intentions and levels of self-disclosure among cancer patients.

Interventions to improve spiritual well-being in adult patients with cancer: a rapid review

Interventions to improve spiritual well-being in adult patients with cancer: a rapid review

Causes of concomitant strabismus surgery delay in teenagers and adults

ABSTRACT To reveal the reasons for strabismus surgery delay and motivations for seeking surgical treatment in adulthood. Prospective survey among 91 adult patients, suffering from concomitant strabismus acquired in the childhood that underwent delayed strabismus surgery. The mean age of participants was 24 years (from 16 to 58 years); 48 females (52.7%), and 43 males (47.3%). Strabismus surgery has been delayed for about 20 years in adult patients who could potentially benefit of it in childhood. The most common reasons for strabismus surgery delay, reported by patients, included the following: lack of awareness about surgery (37.4%); surgery was recommended but declined by patients’ parents/guardians in their childhood (6.6%); fear of surgery (17.6%); eye specialists affirmation that surgery would not lead to strabismus improvement (27.5%); previous poor surgical experience (6.6%); and non-affordability (4.4%). The main motivations for seeking strabismus surgery in adulthood among our patients were the following: appearance improvement (38.5%), strengthening of self-confidence (30.8%), better social relationship (16.5%), better job opportunities (7.7%), and advice from family and friends (6.6%). About 80% of strabismus surgery delays in teenagers and adults were caused by lack of awareness regarding strabismus surgery and even the misconception among primary health-care practitioners and some eye doctors who considered that surgery would not lead to strabismus correction. The main reasons for seeking strabismus surgery in adulthood were: esthetical ones, self-confidence strengthening, and building better social relationship. All factors mentioned below confirmed the negative impact of oculomotor disorders on patient’s psychological condition. The focus on patient’s individual concerns and needs was especially important for recovery and well-being of adult patients with strabismus and formed a central feature of patient centered medical approach.

The Effect of Integrative Counselling on Psychological Well-Being in Adult Patients with Cancer: A Mixed Methods Study

ABSTRACT Objectives: This study aimed to (1) investigate the effectiveness of short-term integrative counselling on the psychological well-being of adult patients with cancer and (2) explore their reported experience of receiving integrative counselling. Design: A mixed-methods embedded design was used to compare psychological well-being in two groups of patients with cancer; one group (n = 15) received 6–9 weekly, hour-long sessions of integrative counselling, and the other group (n = 16) were on the wait list. Methods: Pre and post-intervention symptoms of anxiety, symptoms of depression and levels of self-esteem were measured using the Hospital Anxiety and Depression Scale and the Rosenberg Self-Esteem Scale. The counselling group also answered an open-ended qualitative question with the posttest measures about changes they experienced through having had counselling. Results: In the counselling group, there were substantial and statistically significant improvements in symptoms of anxiety, symptoms of depression, and levels of self-esteem. No significant changes were observed in the wait list group. Three themes of change experienced through counselling were identified in the qualitative data: Acceptance, Self-Awareness, and Moving Forward. Conclusion: Short-term integrative counselling is an effective therapeutic intervention for improving psychological well-being in adult patients with cancer.

Psychological Well-Being in Adult Patients Suffering From Congenital Heart Disease: A Salutogenic Approach From a Chilean Experience.

Psychological Well-Being in Adult Patients Suffering From Congenital Heart Disease: A Salutogenic Approach From a Chilean Experience.

Associations between genetics, medical status, physical exercise and psychological well-being in adults with cystic fibrosis

BackgroundCystic fibrosis (CF) is the most common autosomal recessive, life-shortening disease among people of European origin. Type of genetic mutation and regular physical exercise has an impact on clinical outcome....

Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy.

Health-related quality of life (HRQoL) and well-being are concepts that attempt to objectively capture a person's subjective perceptions of vitality and energy. Our objectives were to determine HRQoL and well-being in adult patients diagnosed with inflammatory myopathy who attended at our outpatient clinic and to investigate clinical and biological correlations with these concepts. Sixty-two patients (52 women), with a mean age of 50.7years, were evaluated in this cross-sectional study-47 with dermatomyositis and 15 with polymyositis. Disease damage and activity were assessed with the International Myositis Assessment and Clinical Studies-validated instruments. Manual muscle testing was used to evaluate muscle strength. Quality of life was evaluated with the WHO instrument (WHO Quality of Life Measure (WHOQOL-BREF)), adapted for use in the Spanish population, and well-being with the WHO-Five Well-Being Index (WHO-5). t tests were conducted to examine differences in HRQoL and well-being outcomes in relation to several disease- and patient-related variables. Correlation analyses were performed with the Pearson correlation coefficient. None of the clinical or biological variables analyzed was significantly associated with a poorer HRQoL or well-being. No differences in HRQoL or WHO-5 well-being score were found between the two myositis subgroups (dermatomyositis vs. polymyositis). Disease activity and muscle weakness were negatively associated with the physical and environmental domains of the HRQoL, respectively (p < 0.002), but not with well-being. Disease duration did not have a significant impact on HRQoL or well-being. In adult patients with myositis, disease activity and muscle weakness are associated with poorer HRQoL in the physical health and environmental domains, respectively.

Holding Back Moderates the Association Between Health Symptoms and Social Well-Being in Patients Undergoing Hematopoietic Stem Cell Transplantation

ContextHolding back, or withholding discussion of disease-related thoughts and emotions, is associated with negative outcomes including lower quality of life, diminished well-being, and relational distress. For patients undergoing hematopoietic stem cell transplantation (HSCT), the degree to which one holds back from discussing illness-related concerns may be an important determinant of social well-being and health; however, this has not been systematically assessed in this population. ObjectivesThe purpose of the present study was to assess the moderating effects of holding back discussion of disease-related concerns on the relationship between health-related symptoms and social well-being in adult patients undergoing HSCT. MethodsSeventy autologous (n = 55) and allogeneic (n = 15) HSCT patients completed measures of holding back, social well-being, and health symptoms (i.e., pain, fatigue, sleep problems, cognitive problems) both before and after transplantation (i.e., three months after transplantation and six months after transplantation). ResultsIn patients with average to high levels of holding back, health symptoms were significantly related to lower levels of social well-being; however, for patients with low levels of holding back, the relationship between health symptoms and social well-being was not significant. ConclusionThe results of the present study suggest that the level of holding back may be important in understanding how health-related symptoms relate to social well-being in patients undergoing HSCT. These findings underscore the importance of addressing how patients undergoing HSCT communicate about their disease with others as this may be related to their adjustment to illness and treatment.

Relationship between Illness-related Cognition and Well-being in Adult Patients with Atopic Dermatitis: Development of Negative and Positive Cognition Scales for Atopic Dermatitis and Influences of Cognitive Pattern on the Quality of Life and Self-affirmation

This study aimed to develop a scale to assess illness-related cognition in adult patients with atopic dermatitis (AD) and examine the influences of cognition on well-being. A questionnaire concerning AD-related cognition, quality of life (QOL) , and self-affirmation was answered by 197 patients (aged 16-70 years; M=33.15, SD=10.38) . Exploratory and confirmatory factor analyses were conducted to examine the factor structure of Negative Cognition Scale for Atopic Dermatitis (NCS-AD) and Positive Cognition Scale for Atopic Dermatitis (PCS-AD) , both comprising three factors. Cluster analysis was conducted to reveal the subjects' cognitive patterns; consequently, the subjects could be classified into five groups. One-way ANOVA was used to find differences among the groups and it revealed the following characteristics: (1) the group with a high score in NCS-AD and a low score in PCS-AD was lower in both QOL and self-affirmation, (2) the group with a low score in NCS-AD was higher in both QOL and self-affirmation, and (3) the group with a high score in PCS-AD was lower in QOL, but higher in self-affirmation. Thus, measures that aim to reduce negative cognition and encourage positive cognition toward AD could be useful in promoting patients' well-being.

Validation of the Clinical COPD Questionnaire as a psychophysical outcome measure in adult laryngotracheal stenosis

To validate the Clinical Chronic Obstructive Pulmonary Disease Questionnaire (CCQ), a patient-administered instrument developed for bronchopulmonary disease as a disease-specific psychophysical outcome measure for adult laryngotracheal stenosis. Prospective observational study. Tertiary/National referral airway reconstruction centre. Thirty-three tracheostomy-free patients undergoing endoscopic laryngotracheoplasty. CCQ and the Medical Research Council (MRC) Dyspnoea scale, a previously validated but more limited scale, were administered to patients 2 weeks before surgery, preoperatively, and 2 weeks after endoscopic laryngotracheoplasty. Pulmonary function was assessed preoperatively. Internal consistency was assessed with Cronbach alpha statistics and test-retest reliability was determined using intraclass correlation. Correlations between CCQ and MRC scale, and pulmonary function were used to assess convergent and divergent validity respectively. Instrument responsiveness was assessed by correlating total and domain-specific CCQ scores with anatomical disease severity and post-treatment effect size. There were 12 males and 21 females. Mean age was 44 +/- 15 years. Cronbach alpha coefficient and intraclass correlation coefficient were 0.88 and 0.95 respectively. Total and domain-specific CCQ scores significantly correlated with the MRC scores (P < 0.001) and significant correlations between CCQ and peak expiratory flow rate and FEV(1) were identified (P < 0.03). There were statistically significant changes in total and domain-specific CCQ scores when different stenosis severities were compared. Clinical COPD Questionnaire scores also changed significantly and congruently following surgery (P < 0.05 in both cases). Clinical COPD Questionnaire is a valid and sensitive instrument for assessing symptom severity and levels of function and well-being in adult patients with laryngotracheal stenosis and can be used as a patient-centred disease-specific outcome measure for this condition.

Subjective effects ofLepidium meyenii(Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial

Lepidium meyenii (Maca) is a cultivated root belonging to the brassica family used in the Andean region for its supposed aphrodisiac properties. We carried out a double-blind clinical trial on 50 Caucasian men affected by mild erectile dysfunction (ED), randomised to treatment with Maca dry extract, 2400 mg, or placebo. The treatment effect on ED and subjective well-being was tested administrating before and after 12 weeks the International Index of Erectile Function (IIEF-5) and the Satisfaction Profile (SAT-P). After 12 weeks of treatment, both Maca- and placebo-treated patients experienced a significant increase in IIEF-5 score (P < 0.05 for both). However, patients taking Maca experienced a more significant increase than those taking placebo (1.6 +/- 1.1 versus 0.5 +/- 0.6, P < 0.001). Both Maca- and placebo-treated subjects experienced a significant improvement in psychological performance-related SAT-P score, but the Maca group higher than that of placebo group (+9 +/- 6 versus +6 +/- 5, P < 0.05). However, only Maca-treated patients experienced a significant improvement in physical and social performance-related SAT-P score compared with the baseline (+7 +/- 6 and +7 +/- 6, both P < 0.05). In conclusion, our data support a small but significant effect of Maca supplementation on subjective perception of general and sexual well-being in adult patients with mild ED.

P-97 Gender Differences in Influences of Stressors on Subjective Well-Being in Adult Patients with Atopic Dermatitis(ISPOG2007)

P-97 Gender Differences in Influences of Stressors on Subjective Well-Being in Adult Patients with Atopic Dermatitis(ISPOG2007)

Ôkar preoperativ information patientens välbefinnande postoperativt?

A review has been made on 22 studies to examine the effect of preoperative information on the patients' postoperative well-being. The most frequent variables studied were: knowledge, hospital stay, physical activity, pain, anxiety and satisfaction. In 17 of the 22 studies reviewed, preoperative information had a positive influence on the results, i.e. decreased hospital stay, pain or anxiety. The remaining five studies could not show any influence of preoperative information on the variables studied. According to our review, preoperative information increased the well-being of adult patients after surgery. Further, a structural rationalisation of the preoperative information can save both time and money. This review is written in Swedish.

Do depressed patients in different treatment settings have different levels of well-being and functioning?

Differences in the functioning and well-being of adult patients with current or past depressive disorder who visited clinicians of different specialties in health maintenance organizations, solo practices, or large multispecialty group practices were examined. For patients in different systems, there were no significant differences in functioning and well-being across 12 domains tested. Patients of mental health specialists had worse mental health and more limitations in social activities, whereas patients of medical clinicians had worse physical functioning, more pain, more physical/psychophysiologic symptoms, and worse health perceptions. Thus, each system of care had depressed patients with a similar functioning and well-being "burden" but specialty sectors had patients with slightly different functioning and well-being profiles, probably reflecting patient selection of type of provider.