Q345B/2205 dissimilar steel multi-layer multi-pass welded joints were prepared using gas metal arc welding (GMAW). The effects of heat inputs on the microstructures and properties of welded joints were studied. The morphology and composition distribution of Q345B base metal near the fusion line were investigated. The results showed that the welded joints under different heat inputs were all present “carbon depleted zone” and “carburized zones” on both sides of the Q345B base metal and transition layer interface. The microstructure of the “carburized zones” was composed of martensite phase and granular bainite phase. It was found that only the welded joints with heat inputs of 1.765 kJ/mm and 2.860 kJ/mm met the usage requirements. The corrosion behavior and characteristics of the welded joint with a heat input of 1.765 kJ/mm in a 3.5 wt % NaCl solution were investigated intensively. During the soaked process of 14 days, the total impedance value of the welded joint showed first increasing and then decreasing. The maximum value of 8.7 kΩ cm2 was obtained on the 5th day. As the soaked time increased, the corrosion products of the welded joint underwent the formation, thickening, cracking and detachment, which was the main reason of the change in the corrosion resistance. The research results of this article have significant implications for the application of low-alloy steel and stainless steel welded joints in engineering.