Background: Weed infestation is a primary cause of reduced yields, with estimated losses ranging from 10-70% due to crop-weed competition in Indian mustard. Therefore, it is essential to implement effective weed control measures to optimize the crop¢s yield potential. A combination of herbicides with manual, culturaland mechanical approaches is desirable to achieve optimal weed control. Therefore, a field experiment was carried out to evaluate the effect of integrated weed management on the productivity and profitability of Indian mustard. Methods: The experiment was conducted at the Agronomy Main Research Farm, College of Agriculture, Orissa University of Agriculture and Technology (OUAT), Bhubaneswar during rabi season of 2021-22 and 2022-23. It consisted of eight treatments in a randomized block design (RBD) with three replications. Result: Pendimethalin 0.75 kg ha-1 fb straw mulch 5 t ha-1 controlled the mixed flora of weeds which resulted in the lowest weed density, weed dry weight, weed index and highest weed control efficiency which resulted in the highest grain yield and stover yield of mustard. Pre-emergence application of pendimethalin 0.75 kg ha-1 fb straw mulch 5 t ha-1 registered the highest benefit-cost ratio.