Web Portal Research Articles

The impact of COVID-19 on tuberculosis in most populated state of India: A geospatial meta-analysis.

Tuberculosis is one of the major burdens to developing nations. India is among the countries categorized by the World Health Organization (WHO) as experiencing a significant burden of TB, HIV-associated TB, and MDR/RR-TB within the context of low- and middle-income nations. Globally South East Asian and African region alone accounted for 82% of death (HIV negative), where India accounts for 36% of TB fatalities. The data was extracted from NIKSHAY web portal on TB notification cases in UP, India. The random effects meta-analysis was performed to estimate pooled proportion of TB cases in public and private notified during both the periods. Spatial analysis was used to display the spread of TB cases across the state, during both the periods. A total 75 districts data on TB notified cases were available for current investigation. The pooled proportion of TB cases were 0.24 (0.21, 0.27) and 0.76 (0.73, 0.79) during COVID-19 period for private and public hospitals, respectively. Similarly, the pooled proportion of TB cases were 0.26 (0.23, 0.29) and 0.74 (0.71, 0.77) post-COVID-19 for private and public hospitals, respectively. The proportion of TB cases were more in public hospital as compared to private hospitals during COVID-19 period. Similarly, result was obtained in post-COVID-19 period.

Predicting and interpreting digital platform survival: An interpretable machine learning approach

Despite the substantial economic impact of digital platforms, research on platform risk evaluation has been sparse. In this study, we investigate whether online content can serve as leading indicators of digital platform survival. We employ machine learning techniques to extract features from three types of online content, that is, user generated content, platform generated content, and third party generated content and examine their utilities in predicting platform survival. Using a predictive XGBoost algorithm and data crawled from a leading web portals of digital platforms for online lending in China, we find online content are strong predictors of platform survival. Furthermore, we use casual forest models to reveal the differences among the three type of online content in terms of predictive utility. Interestingly, we find the presence of third-party generated content indicates lower probability of platform survival while the platform with more user generated content has higher chance to survive. The relationship between platform generated contents and platform failure is not significant. Based on the results, we provide practical implications for market managers and platform owners.

Delivery of Allied Health Interventions Using Telehealth Modalities: A Rapid Systematic Review of Randomized Controlled Trials.

Objectives: To determine whether allied health interventions delivered using telehealth provide similar or better outcomes for patients compared with traditional face-to-face delivery modes. Study design: A rapid systematic review using the Cochrane methodology to extract eligible randomized trials. Eligible trials: Trials were eligible for inclusion if they compared a comparable dose of face-to-face to telehealth interventions delivered by a neuropsychologist, occupational therapist, physiotherapist, podiatrist, psychologist, and/or speech pathologist; reported patient-level outcomes; and included adult participants. Data sources: MEDLINE, CENTRAL, CINAHL, and EMBASE databases were first searched from inception for systematic reviews and eligible trials were extracted from these systematic reviews. These databases were then searched for randomized clinical trials published after the date of the most recent systematic review search in each discipline (2017). The reference lists of included trials were also hand-searched to identify potentially missed trials. The risk of bias was assessed using the Cochrane Risk of Bias Tool Version 1. Data Synthesis: Fifty-two trials (62 reports, n = 4470) met the inclusion criteria. Populations included adults with musculoskeletal conditions, stroke, post-traumatic stress disorder, depression, and/or pain. Synchronous and asynchronous telehealth approaches were used with varied modalities that included telephone, videoconferencing, apps, web portals, and remote monitoring, Overall, telehealth delivered similar improvements to face-to-face interventions for knee range, Health-Related Quality of Life, pain, language function, depression, anxiety, and Post-Traumatic Stress Disorder. This meta-analysis was limited for some outcomes and disciplines such as occupational therapy and speech pathology. Telehealth was safe and similar levels of satisfaction and adherence were found across modes of delivery and disciplines compared to face-to-face interventions. Conclusions: Many allied health interventions are equally as effective as face-to-face when delivered via telehealth. Incorporating telehealth into models of care may afford greater access to allied health professionals, however further comparative research is still required. In particular, significant gaps exist in our understanding of the efficacy of telehealth from podiatrists, occupational therapists, speech pathologists, and neuropsychologists. Protocol Registration Number: PROSPERO (CRD42020203128).

Effects of genetic risk on incident type 2 diabetes and glycemia: the T2D-GENE lifestyle intervention trial.

Lifestyle intervention prevents or delays type 2 diabetes (T2D) in subjects at a high risk of T2D. However, it is not known whether genetic variants modify the effect on incident T2D during lifestyle intervention. To investigate whether a low or high genetic risk has effects on incident T2D in a group-based lifestyle intervention study. The T2D-GENE trial involved 973 men from the Metabolic Syndrome in Men (METSIM) cohort, aged 50-75 years, body mass index ≥25 kg/m2, fasting plasma glucose 5.6-6.9 mmol/l, and HbA1c <48 mmol/mol and either a low or high genetic risk score for T2D. There were two intervention groups, a low (n=315) and high genetic risk for T2D (n=313). They were provided with a 3-year group-based intervention with access to a web portal focused on healthy diet and physical activity. There were also corresponding population-based control groups at low (n=196), and high genetic risk for T2D (n=149) who had two laboratory visits (0 and 3 years) and general health advice as a part of their METSIM cohort protocol. The primary outcome was incident T2D, and a secondary outcome glycemia. The intervention significantly lowered the risk of T2D among the participants with a high genetic risk for T2D (HR 0.30, 95% CI 0.16-0.56, p<0.001) whereas in the low genetic risk group the effect was not significant (HR 0.69, 95% CI 0.36-1.32, p=0.262). The intervention effect was not significantly different between the high and low genetic risk groups (p=0.135). The intervention significantly ameliorated the worsening of glycemia and decreased weight both in the low and high genetic risk groups. Our results showed that individuals with a high genetic risk for T2D benefited from a low-cost group-based intervention focusing on healthy diet and physical activity. Therefore, all individuals at risk of T2D should be encouraged to make lifestyle changes regardless of genetic risk.

Unmanned surface vehicle for intelligent water quality assessment to promote sustainable human health

ABSTRACT Deteriorating water quality poses a substantial risk to human health, with billions at risk of waterborne diseases due to contamination. Insufficient water quality data augment risks as conventional monitoring methods lack comprehensive coverage. Technologies like the Internet of Things and machine learning offer real-time water quality monitoring and classification. IoT nodes often provide point data insufficient for monitoring the quality of entire water bodies. Remote sensing, though useful, has limitations such as measuring only optically active parameters and being affected by climate and resolution issues. To address these challenges, an unmanned surface vehicle named `AquaDrone' has been developed. AquaDrone traverses water bodies, collecting data of four key parameters (pH, dissolved oxygen, electrical conductivity, and temperature) along with GPS coordinates. The data is transmitted to a web portal via LoRa communication and Wi-Fi, where visualizations like data tables, trendlines and color-coded heatmaps are generated. A multilayer perceptron classifies water quality into five categories, aiding in real-time classification. A comparative analysis of various oversampling techniques has been conducted in the context of water quality classification. The AquaDrone offers a feasible solution for monitoring quality of small to medium-sized water bodies, crucial for safeguarding public health.

Information Services of Fundraising Organisations’ Internet Portals

The purpose of the research is to make an information and analytical review and characterise the typical information services of Internet portals used by fundraising organisations in Ukraine and abroad. Research methods. The following general scientific methods were used: systematisation (in the process of selecting the necessary sources of information), generalisation (in the process of defining general concepts that highlight the main features), formal-logical method (in the process of studying the structure and classification of portals), method of systematic analysis of information (in the process of reviewing Ukrainian and foreign experience of the functioning of typical web portals), descriptive method. The scientific novelty of the research is to determine the differences between a website and a web portal; to generalise (based on the results of the analytical monitoring) and to highlight typical information services of fundraising web portals and their functional features that are actively used by domestic and foreign fundraising organisations. Conclusions. The results of the study conclude that Ukrainian fundraising organisations, using benchmarking methods, are actively studying the experience of foreign institutions working in the social sphere and gradually introducing and developing fundraising in the Ukrainian Internet segment. Today, domestic and foreign fundraising activities are carried out through a large number of relevant Internet portals. The relevance of utilizing Internet portals is driven by the fact that an informational web portal contributes to greater transparency of processes occurring within civil society. Moreover, the functional capabilities of Internet technologies help to establish joint work and highlight the activities of both domestic and foreign non-governmental organisations in the digital environment. The research results indicate that the development of the Internet portal market and the constant demand for such services are driving developers to expand the functionality of typical information services and tools that help organisations create user-oriented digital content management capabilities, mobile support, etc. In general, the ratio of the number of foreign and Ukrainian fundraising web portals shows that domestic fundraising is becoming more active and popular in the form of patronage, sponsorship and support through grants, donations, material and information resources, etc. through online portals. It is digital tools and technologies that make it possible for such organisations to remain relevant, with a range of information services and services that are constantly growing and becoming more customer-oriented.

Comparison of open science portals of India: web accessibility study

PurposeThe purpose of this paper is to compare ten Open Science Portals in India. The comparison is made using the three primary parameters of accessibility, search engine optimization (SEO) and performance. This study aims to investigate whether the ten selected web portals efficiently meet the web accessibility requirements of the large population at an acceptable rate.Design/methodology/approachThis study was performed by using the Siteimprove web tool to collect information about Web Content Accessibility Guidelines (WCAG) 2.0. The online accessibility tools provided by Siteimprove make it simple to comply with and follow the global WCAG at all compliance levels. This study selected ten web portals taking into account the open accessibility and the web portals offered by the Indian Government to promote research and innovation.FindingsThe findings of this research will be beneficial for the government website designers, managers and administrators to assess their website’s level of compliance with accepted accessibility standards so they can make tactical choices to increase accessibility.Originality/valueThis study highlights the portals’ robust characteristic features and downsides, where improvement may be required. It also focused on how these portals help in promoting citizen science and public understanding of science nationwide.

A methodological approach for data standardization and management of Open Data portals for scientific research groups: a case study on mobile and ubiquitous ecosystems

IntroductionIn the scientific research domain, the Open Science movement stands as a fundamental pillar for advancing knowledge and innovation globally. This article presents the design and implementation of the GITCE Open Data Ecosystem (GITCE-ODE) Research Data Management System (RDMS), developed by the Research Group on Emerging Computational Technologies (GITCE) at the Technological University of Panama, as a platform for the long-term storage, publication, and dissemination of research products.MethodsThe architecture of the GITCE-ODE RDMS encompasses the entire data engineering lifecycle, facilitating information processing stages such as extraction, transformation, loading (ETL), as well as the management and analysis of diverse datasets and metadata.ResultsCompliance with the FAIR principles ensures that published data and products are Findable, Accessible, Interoperable, and Reusable, promoting automation in the discovery and reuse of digital resources. Key considerations of the web portal include file format standardization, data categorization, treatment of semantic context, and organization of resources to ensure efficient management and administration of open research data.DiscussionThrough this platform, GITCE aims to foster collaboration, transparency, and accessibility in scientific research, contributing to the ongoing advancement of knowledge transfer and innovation.

RCSB protein Data Bank: exploring protein 3D similarities via comprehensive structural alignments.

Tools for pairwise alignments between 3D structures of proteins are of fundamental importance for structural biology and bioinformatics, enabling visual exploration of evolutionary and functional relationships. However, the absence of a user-friendly, browser-based tool for creating alignments and visualizing them at both 1D sequence and 3D structural levels makes this process unnecessarily cumbersome. We introduce a novel pairwise structure alignment tool (rcsb.org/alignment) that seamlessly integrates into the RCSB Protein Data Bank (RCSB PDB) research-focused RCSB.org web portal. Our tool and its underlying application programming interface (alignment.rcsb.org) empowers users to align several protein chains with a reference structure by providing access to established alignment algorithms (FATCAT, CE, TM-align, or Smith-Waterman 3D). The user-friendly interface simplifies parameter setup and input selection. Within seconds, our tool enables visualization of results in both sequence (1D) and structural (3D) perspectives through the RCSB PDB RCSB.org Sequence Annotations viewer and Mol* 3D viewer, respectively. Users can effortlessly compare structures deposited in the PDB archive alongside more than a million incorporated Computed Structure Models coming from the ModelArchive and AlphaFold DB. Moreover, this tool can be used to align custom structure data by providing a link/URL or uploading atomic coordinate files directly. Importantly, alignment results can be bookmarked and shared with collaborators. By bridging the gap between 1D sequence and 3D structures of proteins, our tool facilitates deeper understanding of complex evolutionary relationships among proteins through comprehensive sequence and structural analyses. The alignment tool is part of the RCSB PDB research-focused RCSB.org web portal and available at rcsb.org/alignment. Programmatic access is available via alignment.rcsb.org. Frontend code has been published at github.com/rcsb/rcsb-pecos-app. Visualization is powered by the open-source Mol* viewer (github.com/molstar/molstar and github.com/molstar/rcsb-molstar) plus the Sequence Annotations in 3D Viewer (github.com/rcsb/rcsb-saguaro-3d).

Prevalence of ALS in all 50 states in the United States, data from the National ALS Registry, 2011–2018

Objective: To summarize the prevalence of ALS in all 50 states and Washington, DC in the United States from 2011 to 2018 using data collected and analyzed by the National ALS Registry. In October 2010, the federal Agency for Toxic Substances and Disease Registry (ATSDR) launched the congressionally mandated Registry to determine the incidence and prevalence of ALS within the USA, characterize the demographics of persons with ALS, and identify the potential risk factors for the disease. This is the first analysis of state-level ALS prevalence estimates. Methods: ALS is not a notifiable disease in the USA, so the Registry uses a two-pronged approach to identify cases. The first approach uses existing national administrative databases (Medicare, Veterans Health Administration, and Veterans Benefits Administration). The second method uses a secure web portal to gather voluntary participant data and identify cases not included in the national administrative databases. Results: State-level age-adjusted average prevalence from 2011–2018 ranged from 2.6 per 100,000 persons (Hawaii) to 7.8 per 100,000 persons (Vermont), with an average of 4.4 per 100,000 persons in the US. New England and Midwest regions had higher prevalence rates than the national average. Conclusions: These findings summarize the prevalence of ALS for all 50 states from 2011 to 2018. This is a continuing effort to identify ALS cases on a national population basis. The establishment of the National ALS Registry has allowed for epidemiological trends of this disease and the assessment of potential risk factors that could cause ALS.

Design and Implementation of an Efficient Franchise Management System: Enhancing Operational Consistency and Growth

Abstract–The Franchisee Web Portal project aims to revolutionize the management and communication processes within franchise networks. Franchise businesses often face challenges in maintaining efficient communication channels and managing operations across multiple locations. This project addresses these challenges by developing a centralized web portal tailored specifically for franchisees.The portal offers a range of features designed to streamline operations and enhance communication among franchisees, franchisers, and other stakeholders.The portal provides a centralized platform for franchisees to communicate with each other and with the franchiser. This fosters collaboration, knowledge sharing, and problem-solving among franchisees, leading to improved operational efficiency and consistency across the network.Overall,the Franchisee Web Portal project represents a significant step forward in modernizing franchise operations and fostering collaboration and communication within franchise networks. By leveraging technology to create a centralized platform tailored to the needs of franchisees, the portal helps drive operational excellence and ensure the long-term success of franchise businesses.The portal features robust reporting and analysis capabilities, allowing franchisees to track key performance metrics, identify trends, and generate insights into their operations. This empowers franchisees to make informed decisions and optimize their businesses for maximum efficiency and profitability. Keywords – Operation Management, Inventory Management, Franchisee Network, Operational Excellence, Knowledge Sharing.

MetaAnalysisOnline.com: A new easy-to-use bioinformatic tool for the meta-analysis of clinical trials.

e23012 Background: A meta-analysis is a formal, quantitative study design in epidemiology and clinical medicine that systematically assesses and consolidates previous research findings to derive comprehensive conclusions on a specific topic. Here, we aimed to establish a new tool for the visualization options useful for conducting a meta-analysis specifically designed for oncology trials. Methods: A meta-analysis can be based on binary data, continuous data, or time-to-event data. The most crucial statistical models, including the random effect model and the fixed effect model, are outlined alongside their respective statistical methods. Furthermore, we implemented graphical representations such as the forest plot, funnel plots, and Z-scope plots. While the forest plot effectively illustrates heterogeneity and pooled results, a funnel plot can reveal potential publication bias, and a Z-score plot shows the robustness of the used sample number. Results: The models and visualization options outlined have been integrated into a new, online web portal which can be accessed without the need for registration. The web application operates on an Ubuntu server running Apache and enables users to conduct meta-analyses using results typically used in oncology trials including binary (total and event numbers), continuous (mean and standard deviation data), and time-to-event data (hazard rate and CI data). Study results from common spreadsheet applications like Excel can be directly input into the system. The online platform utilizes the meta and metafor packages in the R programming environment (R version 4.2.2) for calculations and plots. The Shiny user interface is powered by shinyjs, shinydashboard, and rhandsontable R packages. The portal generates a forest plot to summarize meta-analysis results, a funnel plot for visual detection of potential bias, and a Z-score plot showing the sufficiency of the cumulative sample number. The analysis results of the tool were validated using IBM SPSS v28. The new bioinformatic tool is available at www.metaanalysisonline.com and requires no programming knowledge or command line use. Conclusions: Our platform aims to provide a user-friendly meta-analysis tool for epidemiological studies and oncology clinical trials, offering a swift and reproducible way to integrate the results from multiple studies.

Keystone - A Smart Campus

Abstract: Increasing numbers of institutes have set up facilities on their Web portal as a way of providing users (i.e. Students and Faculties) with information about their facilities and features. Generally in colleges, things are done manually such as submission, handouts, notice, results, records, examinations, etc. so to avoid this we are designing a web portal for our institute, which will be helpful in following features like time saving, easy access and user friendly. In this project, we developed a Smart Campus Web Portal called Keystone App. Keystone App offers campus management solutions with the collaboration of smart features, the Internet and computer applications. The system has many features; these are Online Attendance System, Online Noticeboard, providing study materials and many more. It is a digitalization of campus resources in the real world, allowing different resources to be integrated and generating an ecology. The virtual campus interacts powerfully with the physical campus, improving the efficiency of campus operations and promoting the university's long-term development.

Virtual Medicine Wards and Hospital-at-Home Programs

What Is the Issue? In 2021, the occupancy rate of acute care hospital beds in Canada was 86.7%. High occupancy rates without turnover to accommodate all hospitalization needs is an indicator of potential bed shortages and health system pressure. Patients have historically remained in hospital beds until their treatment or recovery is complete. Some patients may be well enough to continue their treatment or recovery at home sooner if provided with the right supports. What Are the Technologies? Virtual wards, also known as hospital-at-home programs, support the provision of inpatient-level acute medical care in a patient’s home. There are 2 main models of these programs: admission avoidance and supported early discharge. This report focuses on the latter type. Many of these programs are technology-enabled and incorporate remote monitoring devices to record the patient’s vital signs and tablets or web portals to facilitate data sharing. Video calls with the clinical team are also used in combination with in-person visits by health care providers. What Is the Potential Impact? Hospital beds can be freed up more quickly to provide space for newly admitted patients with more acute care needs. The safety and effectiveness of virtual ward programs have been examined in several systematic reviews in the existing clinical literature. Factors evaluated include mortality, length of stay, hospital readmissions, and costs as outcomes. Both admission avoidance and early supported discharge via hospital-at-home programs had lower or similar mortality and hospital admission outcomes as inpatient care after completion of care. Patients, caregivers, and health care providers appear to be generally satisfied with their participation in virtual ward programs. Comfort and satisfaction can be improved by allowing patients to receive treatment in a familiar and comfortable environment without compromising patient outcomes. However, increased caregiver burden, lack of sufficient training for participants and staff, and difficulties recruiting health care providers were identified as challenges associated with virtual ward programs. What Else Do We Need to Know? The level of technological support required by patients, caregivers, and staff participating in these programs should be considered when developing a program. Adequate training about how to use provided equipment and other tasks needed to manage care in the home (e.g., drug administration, symptom monitoring, communication with health care professionals) is required for patients and caregivers. There should also be provision of all necessary equipment with supports to overcome any barriers (e.g., visual impairment, physical limitations) to ensure comfort and proficiency. Care coordination and communication among the multidisciplinary care team, the patient, and their caregivers is important. Canadian cost data were not identified, but it is generally accepted that virtual ward programs are associated with reduced costs when compared with traditional in-hospital care. The inclusion of digital monitoring and record keeping technologies as part of virtual ward programs may disproportionately exclude people from some groups, including older people, people living in social housing or without housing, people with lower incomes, people who are unemployed, people living with disabilities, and people who live in rural areas without access to such programs. Key recommendations for development of virtual ward programs in Canada include using a single remote patient-monitoring platform that connects with the hospital’s electronic health record system, choosing a technology to connect patients and providers that best fits the needs of the virtual ward program, and ensuring data security, confidentiality, and data management protocols are in place.

Neuroanatomical alterations in brain disorder: A magnetic resonance imaging analysis

Background: Bipolar disorder is a serious mental disorder caused by strong mood fluctuations, affecting 2% of the world's population. People with bipolar disorder experience both manic and depressive episodes, which can lead to suicidal thoughts and changes in appetite, activity, and focus. There are different subtypes of bipolar disorder, with cyclothymic disorder being the milder of the two. Bipolar I is characterized by manic periods, while bipolar II is marked by hypomanic and significant depressive episodes. Bipolar disorder is a biological, genetic, and environmental condition that can affect anyone at any age. Methods: In this study, we enrolled a total of 49 bipolar disorder (BD) participants to 44 healthy control (HC) subjects. Bipolar disorder patients were enlisted with their consent using web portals, medical facilities, and local marketing. MRI contraindications, medical history, self-reported using a mood-altering medication, inadequate vision, and left-handedness were among the exclusion criteria. The various tissue structures which are: the gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined using voxel-based morphometry (VBM) to ascertain these changes. We employed statistical parametric mapping (SPM) for both image processing and statistical analysis. Results: Our findings demonstrate that individuals with bipolar disorder showed a substantial volume decrease in both gray matter (GM) and white matter (WM), with gray matter (GM) and white matter (WM) volume decreases being more noticeable in the frontal, temporal, parietal, and occipital lobes. Additionally, individuals with bipolar disorder showed no CSF volume in any of the brain regions. Conclusion: Our VBM research backs up earlier studies that link changes in brain structure, particularly gray matter and white matter, to bipolar disorder. These discoveries shed more information on the neurology of bipolar disorder and could guide the creation of more potent diagnostic and treatment modalities.

First Report of Globisporangium ultimum Causing Pythium Damping-off and Root Rot on Pepper in Guizhou, China.

Pepper (Capsicum annuum L.) is a popular vegetable and condiment consumed around the world. In the Guizhou Province of China, peppers are the most commonly grown crop on 300,000 planted hectares. A variety of diseases routinely occur on peppers in this province, resulting in yield losses (Liu et al., 2022). Root rot is one of the most common symptoms and produces poor root growth and wilting of pepper. In April 2023, symptomatic pepper plants displaying stunting, dwarfism, wilting, and root browning were collected from five fields in Guizhou, with disease incidence ranging from 10% to 20%. The collected rotten roots were cleaned with sterilize distilled water and placed in selective V8 juice agar (V8A) medium (15% clarified V8 juice with 2.5 g/L CaCO3 and 2% agar) containing nystatin, ampicillin, rifampicin, and miconazole, and incubated at 25℃ for 1 to 2 days (Morita and Tojo, 2007). Eight isolates with similar colony morphology were transferred to V8A medium via hyphal tipping, and incubated at 25℃ in the dark. Colony and sexual structures were observed using a microscope. Mycelium was aseptate and formed white cottony colonies. Globose, intercalary, or terminal hyphal swellings were observed with a diameter of 20.5 to 25 µm (average: 22 µm), and aplerotic oospores had a diameter of 15 to 20 µm (average: 17.5 µm) with a wall thickness of approximately 2 µm. Three representative isolates HSLJ-3, LJG-1, and LJY-2 were chosen for further molecular identification. Sequences of the internal transcribed spacer (ITS) and mitochondrial cytochrome c oxidase subunit 1 (cox1) genes were identified using primer sets ITS4/ITS5 (White et al., 1990) and OomCoxI-Levup/OomCoxI-Levlo (Robideau et al., 2011), respectively. All sequences were deposited in GenBank (accession nos. OR554005, PP083310, and PP083420 for ITS, and OR529247, PP093821 and PP093822 for cox1). BLAST analysis revealed all ITS and cox1 sequences exhibited 100% identity with Globisporangium ultimum (Pythium ultimum) isolate BR850 (GenBank accession nos. HQ643892.1 and HQ708933.1 for ITS and cox1, respectively). Phylogenetic analysis was performed by the maximum-likelihood method on the CIPRES web portal (https://www.phylo.org/portal2/login!input.action, accessed on 9 January 2024). For pathogenicity tests, each isolate was cultured in V8A medium containing 50 autoclaved wheat seeds at 25℃ for 7 days. Budding pepper seedling (cv. Huaxi) was transplanted into a 0.4 L pot containing sterilized commercial potting mix (Seedling Cultivation Substrate, Hunan Xianghui Agricultural E-commerce Co., Ltd.) which was saturated with deionized water. Eight infected and non-infected wheat seeds were placed near the roots of five pepper seedlings, respectively. Plants were placed in an artificial climate chamber, with a 14 h photoperiod and approximately 75% relative humidity at 25℃. After 14 days, inoculated seedlings showed symptoms of stunting, wilting, and rotting roots similar to those observed in the field. No disease was observed on the non-inoculated control plants. The pathogen was isolated from infected pepper roots and confirmed as G. ultimum by morphological and molecular analyses as previously described. This is the first report of G. ultimum causing root rot on pepper in Guizhou, China. This finding is critical to the discover of treatment options for this pathogen, thereby improving management practices to reduce yield losses in pepper.

Online dashboards for SARS-CoV-2 wastewater-based epidemiology.

Aim: Wastewater-based epidemiology (WBE) is increasingly used to monitor pandemics. In this manuscript, we review methods and limitations of WBE, as well as their online dashboards. Materials & methods: Online dashboards were retrieved using PubMed and search engines, and annotated for timeliness, availability of English version, details on SARS-CoV-2 sublineages, normalization by population and PPMoV load, availability of case/hospitalization count charts and of raw data for export. Results: We retrieved 51 web portals, half of them from Europe. Africa is represented from South Africa only, and only seven portals are available from Asia. Conclusion: WBS provides near-real-time cost-effective monitoring of analytes across space and time in populations. However, tremendous heterogeneity still persists in the SARS-CoV-2 WBE literature.

Accessibility of COVID-19-related Public Websites in Japan

ABSTRACT Background During the COVID-19 pandemic, accessible websites and online content have become more critical worldwide as patients seek information about their medical concerns with limited access to care. However, there are still research gaps regarding the accessibility to COVID-19 information in Japan. Purpose This study systematically and quantitatively analyzed COVID-19-related local government websites from official COVID-19 for compliance with WCAG guidelines. Methods On June 25, 2022, we analyzed COVID-19 web portals by Japanese local governments using AChecker, WAVE, and miChecker. These tools are automated accessibility evaluation tool based on Web Content Accessibility Guidelines (WCAG), which are widely used international standards in accessibility. Results Of the 72 websites included, the average number of errors per page was 2.7 (range 0–38) for WAVE and 8.7 (range 0–104) for WCAG 2.0 AA, respectively. The number of errors was lower than the number of accessibility errors on general websites. “Perceivable” errors, such as ambiguous colors/contrasts and missing alternative text, were prominently displayed at the top of the list of web page accessibility errors. Discussion The accessibility of the COVID-19 website of the Japanese local government was deemed satisfactory compared with the average number of accessibility errors on the top 1,000,000 home pages worldwide (50.8 per page). However, the websites lacked support in images (color and text) and audio guidance for users with visual and cognitive impairments. Translation to Health Education Practice For proper user perception, COVID-19 information had to be presented with clear contrast, alternative text, and informative captions.

STOPLIGHT: A Hit Scoring Calculator.

We introduce STOPLIGHT, a web portal to assist medicinal chemists in prioritizing hits from screening campaigns and the selection of compounds for optimization. STOPLIGHT incorporates services to assess 6 physiochemical and structural properties, 6 assay liabilities, and 11 pharmacokinetic properties, for any small molecule represented by its SMILES string. We briefly describe each service and illustrate the utility of this portal with a case study. The STOPLIGHT portal provides a user-friendly tool to guide hit selection in early drug discovery campaigns, whereby compounds with unfavorable properties can be quickly recognized and eliminated.

Implementasi Metode Prototype pada Pembuatan Web Portal TEFA House of Health Promotion

Health Promotion is a series of activities that strive for individuals to increase their knowledge related to health so that ultimately they can improve the quality of health. In order for the objectives of health promotion activities to be achieved, media is needed to support these activities. TeFa House of Health Promotion Polije is one of the TeFa (Teaching Factories) managed by the Health Promotion study program, Department of Health. TeFa was created as a forum for communication, information and health education, TeFa is also a means for lecturers to contribute to society by providing consultation services related to the development of public health promotion programs. To support this, a multifunctional platform is needed in the form of a webportal which is used to help TeFa. This research focuses on creating a web portal using one of the SDLC methods, namely prototype. The process of creating a web portal begins with extracting information through interviews with potential users. The results of this excavation process are information related to the features of the web portal, including articles, video, audio, pooling and chat. The process of creating a Web Portal is made using the PHP programming language and Laravel Framework. The testing process is carried out using the black box method to determine the functionality of each feature. The test results showed that the web portal was in accordance with the user's required features and each feature was functioning according to its function.