Web-based Calculation Research Articles

Diagnosis and Treatment of Myelodysplastic Syndrome in the Era of Genetic Testing

Myelodysplastic syndrome (MDS) is a heterogeneous disorder with diverse prognoses influenced by cytopenias, genetic variants, and myeloblast proportions in the bone marrow. Accurate prognosis prediction and tailored treatment plans are essential. The International Prognostic Scoring System-Molecular (IPSS-M), which additionally reflects the impact of MDS-related genetic mutations to the clinical and laboratory information, is anticipated to offer superior prognostic accuracy compared to existing systems like the Revised International Prognostic Scoring System (IPSS-R). Despite its statistical complexity, its web-based calculation and ease of discussing results with patients using intuitive data sets provide notable advantages. Progress in MDS treatment, exemplified by effective anemia correction with an erythropoiesis-maturation agent in <i>SF3B1</i>-mutated cases and efforts to refine poor prognoses in <i>TP53</i>-mutated cases, reflects the evolving landscape of genetic-based interventions in MDS. Advancements in genetic diagnostic technology, combined with enhanced knowledge of the bone marrow niche, are anticipated to lead to significant improvement in MDS treatment outcomes in the future.

Establishment of a quantitative assessment model and web-based calculation tool for the skeletal muscle index in children

The skeletal muscle index (SMI) is widely used in adults. The reference values for SMI in children are inadequate and require validation in pediatric patients for clinical usefulness. Therefore, this study developed a quantitative assessment model for SMI in children using standard deviation (SD) curves and validated the model's utility and generalizability. We examined three compartments of the abdominal skeletal muscle region. SMI was calculated as skeletal muscle area divided by height squared for each compartment (PMI, psoas muscle index; PSMI, paraspinal muscle index; TSMI, total skeletal muscle index). The optimal model was generated using random grouping methods (training and testing), polynomial regression analysis, and the mean squared error evaluation methods. The generated model was validated with previously published SMI data and clinical data of patients with inflammatory bowel disease. The data of 474 children were analyzed. The previously reported SMI reference values overlapped well with our model. In patients with inflammatory bowel disease, the mean (SD) Z-scores for SMI were low in boys (PMI,-1.15 [1.11]; PSMI,-1.31 [1.07]; TSMI,-0.84 [0.91]) and girls (PMI,-1.22 [1.08]; PSMI,-1.44 [1.19]; TSMI,-0.74 [1.16]). Furthermore, SMI was positively correlated with body weight, body mass index, and serum albumin level, a nutritional marker, and negatively correlated with erythrocyte sedimentation rate, an inflammatory marker. We established a quantitative assessment model for SMI and validated the model's generalizability and clinical usefulness. We generated an easy-to-use calculation tool for Z-scores from skeletal muscle area obtained from computed tomography images, age, and height information; it has been made publicly available (http://square.umin.ac.jp/ped-muscle-calc/index.html).

Prediction of mortality and the development of critical illness in the course of COVID-19 with tertiary hospital data: vaccines? Critical illness scores? Mortality scores?

Even though COVID-19 affects some risk groups more severely than others, there are still unknowns concerning the intensive care procedure and death in non-risk categories, making it vital to identify critical sickness and fatality risk factors at this time. The purpose of this study was to look into the efficacy of critical illness and mortality scores, as well as other risk factors in COVID-19. Two hundred twenty-eight inpatients diagnosed with COVID-19 were included in the study. Sociodemographic, clinical, and laboratory data were recorded and risk calculations were made with the help of web-based patient data-based calculation programs called COVID-GRAM Critical Illness and 4C-Mortality score. The median age of 228 patients included in the study was 56.5 years, 51.3% of them were males, and ninety-six (42.1%) were unvaccinated. According to the multivariate analysis, the factors affecting the development of critical illness were cough [odds ratio=0.303, 95% CI (0.123,0.749), p=0.010], creatinine [odds ratio=1.542, 95% CI (1.100, 2.161), p=0.012], respiratory rate [odds ratio=1.484, 95% CI (1.302, 1.692), p=0.000], COVID-GRAM Critical Illness Score [odds ratio=3.005, 95% CI (1.288, 7.011), p=0.011]. Factors affecting survival were vaccine status [odds ratio=0.320, 95% CI (0.127,0.802), p=0.015], blood urea nitrogen (BUN) [odds ratio=1.032, 95% CI (1.012, 1.053), p=0.002], respiratory rate [odds ratio=1.173, 95% CI (1.070, 1.285), p=0.001], COVID-GRAM-critical-illness score [odds ratio=2.714, 95% CI (1.123, 6.556), p=0.027]. The findings suggested that risk assessment might employ risk scoring, such as COVID-GRAM Critical Illness, and that immunization against COVID-19 will reduce the occurrence of mortality.

Web-Based Zakat Information and Calculation System at Badan Amil Zakat Nasional (BAZNAS) of the Kendari City Using the Laravel Framework

Badan Amil Zakat Nasional (BAZNAS), or the National Amil Zakat Agency, is housed in Kendari City, particularly in the Anduonohu area. BAZNAS is a non-structural government institution independent and responsible to the Ministry of Religious Affairs. It faces several issues with data processing using Microsoft Excel, such as the difficulty of zakat data administration, the time and effort required to create reports, the slowness of search results, and the absence of a database. By developing a web-based zakat information and calculation system at BAZNAS of Kendari City with the Laravel framework, this study aims to discover solutions to issues experienced. The research framework for addressing the issues raised at BAZNAS of Kendari City included problem identification, theoretical foundation-based information searches, data collection through observation and interviews, and application development. Prototyping was utilized as a part of the system development, employing PHP, the Laravel framework and a MySQL database. Black-box testing was applied to ensure everything was working as intended. The test findings unveiled that the web-based zakat information and calculation system at BAZNAS of Kendari City functioned properly.

Upgrading The Web-Based Credit Score Calculation System

The development of the credit score system is a development that aims to streamline the time and performance of Widyaiswara at the Makassar Religious Education and Training Center. However, the previous system development did not have the Overload task verification and credit score features, so Widyaiswara needed manual input. The Abundant Task feature is a feature that allows Widyaiswara to input credit numbers above the position following the provisions for reducing credit scores following applicable regulations. Meanwhile, the credit score verification feature ensures that the credit score entered follows the specified conditions. This study aims to develop these two features for upgrading the system using the Waterfall model development. This model was chosen because it fits the needs of systematic and sequential system development. The test results show that the system has met the ISO/IEC 25010 standard; the functional feasibility is worth 1 (one), which means the system is working well. While the results of the usability test of the system are 90.4%, the system is declared very feasible to input and calculate credit scores efficiently. The result shows that the upgrading of the web-based credit score calculation system has been effectively used for inputting overflow assignments and verifying credit scores.

PERENCANAAN SISTEM INFORMASI PENGHASILAN ANGIN POMPA BAN NITROGEN BERBASIS WEB DI CV. SEKAWAN UTAMA (NITROGEN)

The Researchers write this article aims to conduct income planning analysis of the company. In the company certainly expects an increased income. So it requires a planning in improving that. The web-based calculation will be able to record in detail each time the transaction that has been ubiquitous and more efficient. The impact on these developments have been optimal for the activities in the company. Web in this study is the nitogen web which combines between nitrogen machines with web. In the web system development information planning system requires overall identification. Planning in data information system is actually not a new thing. Planning is an effort in determining various kinds of things that are about to be achieved or seven with various stages in a certain period of time. A system will have an impact on being influenced by the environment. To provide the existence of the web, there are elements supporting. Likewise, in the business field of Nitrogen tire pumps are also many developments to increase management in companies. The role of this web in a company is that it can record all transactions in detail from operating hours of operating machines not operating so it cannot anticipate cheating carried out by employees in the field.

Assessing the introduction risk of vector-borne animal diseases for the Netherlands using MINTRISK: A Model for INTegrated RISK assessment.

To evaluate and compare the risk of emerging vector-borne diseases (VBDs), a Model for INTegrated RISK assessment, MINTRISK, was developed to assess the introduction risk of VBDs for new regions in an objective, transparent and repeatable manner. MINTRISK is a web-based calculation tool, that provides semi-quantitative risk scores that can be used for prioritization purposes. Input into MINTRISK is entered by answering questions regarding entry, transmission, establishment, spread, persistence and impact of a selected VBD. Answers can be chosen from qualitative answer categories with accompanying quantitative explanation to ensure consistent answering. The quantitative information is subsequently used as input for the model calculations to estimate the risk for each individual step in the model and for the summarizing output values (rate of introduction; epidemic size; overall risk). The risk assessor can indicate his uncertainty on each answer, and this is accounted for by Monte Carlo simulation. MINTRISK was used to assess the risk of four VBDs (African horse sickness, epizootic haemorrhagic disease, Rift Valley fever, and West Nile fever) for the Netherlands with the aim to prioritise these diseases for preparedness. Results indicated that the overall risk estimate was very high for all evaluated diseases but epizootic haemorrhagic disease. Uncertainty intervals were, however, wide limiting the options for ranking of the diseases. Risk profiles of the VBDs differed. Whereas all diseases were estimated to have a very high economic impact once introduced, the estimated introduction rates differed from low for Rift Valley fever and epizootic haemorrhagic disease to moderate for African horse sickness and very high for West Nile fever. Entry of infected mosquitoes on board of aircraft was deemed the most likely route of introduction for West Nile fever into the Netherlands, followed by entry of infected migratory birds.

Accurate Estimation of English Word Similarity Based on Semantic Network

The application of artificial intelligence in the field of English needs to process a large amount of English text data, but the deviation of English word similarity reduces its overall English translation accuracy and data processing efficiency. Therefore, this paper proposes an accurate estimation of English word similarity based on semantic network, which combines a variety of computing methods to form a compound computing structure based on semantic network. The experimental results show that the error between the Semantic Web-based English word similarity calculation method and manual evaluation is small, and the accuracy of English word similarity calculation is improved to a certain extent. In addition, compared with other English word similarity calculation methods, the English word similarity calculation method based on semantic network is more in line with people’s cognition and understanding of knowledge, has higher reliability, and has certain practical value in the field of English.

Does a Dose Calculator as an Add-On to a Web-Based Paediatric Formulary Reduce Calculation Errors in Paediatric Dosing? A Non-Randomized Controlled Study.

ObjectivesThe structured digital dosing guidelines of the web-based Dutch Paediatric Formulary provided the opportunity to develop an integrated paediatric dose calculator. In a simulated setting, we tested the ability of this calculator to reduce calculation errors.MethodsVolunteer healthcare professionals were allocated to one of two groups, manual calculation versus the use of the dose calculator. Professionals in both groups were given access to a web-based questionnaire with 14 patient cases for which doses had to be calculated. The effect of group allocation on the probability of making a calculation error was determined using generalized estimated equations (GEE) logistic regression analysis. The causes of all the erroneous calculations were evaluated.ResultsSeventy-seven healthcare professionals completed the web-based questionnaire: thirty-seven were allocated to the manual group and 40 to the calculator group. Use of the dose calculator resulted in an estimated mean probability of a calculation error of 24.4% (95% CI 16.3–34.8) versus 39.0% (95% CI 32.4–46.1) with use of manual calculation. The mean difference of probability of calculation error between groups was 14.6% (95% CI 3.1–26.2; p = 0.013). In a secondary analysis where calculation error was defined as a 10% or greater deviation from the correct answer, the corresponding figures were 19.5% (95% CI 13–28.2) versus 26.5% (95% CI 21.6–32.1) with a mean difference of 7% between groups (95% CI 2.2–16.3; p = 0.137). Juxtaposition, typo/transcription errors and non-specified errors were more frequent as cause of error in the calculator group; exceeding the maximum dose and wrong correction for age were more frequent in the manual group. The percentage of tenfold errors was 3.1% in the manual group and 3.7% in the calculator group.ConclusionsOur study shows that the use of a dose calculator as an add-on to a web-based paediatric formulary can reduce calculation errors. Furthermore, it shows that technologies may introduce new errors through transcription errors and wrongly selecting parameters from drop-down lists. Therefore, dosing calculators should be developed and used with special attention for selection and transcription errors.

Setting Standards: Extending the VDmax Approach: AAMI TIR76 and Its Web-Based Calculation Tool.

Setting Standards: Extending the VDmax Approach: AAMI TIR76 and Its Web-Based Calculation Tool.

Determination of Ecological and Carbon Footprints of Adıyaman Directorate of Provincial Agriculture and Forestry Staffs

Humans have always benefited from natural sources to satisfy their needs. Today, with the increase in population, the natural resources on our earth are decreasing and assumed to be consumed in the near future because of the consciousness of the individuals and the consciousness of consumption away from sustainability. It is important to determine how many planets the world will need in the future if the individual continues to live that way with his current consumption habits. The concept of ecological footprint emerges in determining this need. In this study, ecological and carbon footprints were calculated and evaluated according to the consciousness and consumption habits of Adiyaman Directorate of Provincial Agriculture and Forestry staffs. Web-based Ecological Footprint Calculation Survey was used as data collection tool in the research. Descriptive statistics such as mean, standard deviation were used in the analysis of the data. As a result of the calculations, the average ecological footprint of technical and administrative staffs was determined as 2.37 gha person -1 , the average carbon footprint was 14.52 tons person -1 and the biocapacity deficit caused by technical and administrative staffs was -0.93 gha person -1 . According to these results, at least 1.41 worlds are needed for Adiyaman Directorate of Provincial Agriculture and Forestry staffs for a sustainable life.

웹 기반 초고속 신약 후보물질 탐색-계산 시스템 구현

이 논문에서는 nanoluciferase 시스템의 생화학 반응 과정에서 도출한 데이터를 고속으로 계산하고 신약 후보물질을 신속히 찾아내도록 보조하는 웹 기반 초고속 계산-탐색 시스템(HTSCS) 개발 결과물을 설명한다. 이 시스템에서는 단일 농도(Single-Dose)와 다중 농도(Multi-Dose)로 세포 실험체에 후보물질을 투여(in-vitro)한 대량의 실험 데이터를 계산하여, 차트 및 그래프 정보로 나타낸다. 따라서 HTSCS 시스템으로 신약 후보물질 발견에 필요한 시간과 노력을 줄일 수 있다.

Development of Web-based Matrix Operations Calculation as a Learning Media

This study aims to build a web-based matrix operations calculation that can be used for students as learning media. There are some students having difficulties to learning matrix. Some of the difficulties are limited alternative learning media, they only study from books or presentation slide. These media are not interactive. This learning media is built using prototyping model process. The stages of prototyping model process are communication, quick plan, modelling quick design, construction, and deployment. The result of this study is a web-based matrix operations calculation that has feature to calculate addition, subtraction, multiplication, determinant, and transpose matrix.

Development of Web-based Matrix Operations Calculation as a Learning Media

Development of Web-based Matrix Operations Calculation as a Learning Media

DEVELOPMENT OF AGE-SPECIFIC JAPANESE PHYSICAL PHANTOMS FOR DOSE EVALUATION IN INFANT CT EXAMINATIONS.

Secondary to the previous development of age-specific Japanese head phantoms, the authors designed Japanese torso phantoms for dose assessment in infant computed tomography (CT) examinations and completed a Japanese 3-y-old head-torso phantom. For design of age-specific torso phantoms (0, 0.5, 1 and 3 y old), anatomical structures were measured from CT images of Japanese infant patients. From the CT morphometry, it was found that rib cages of Japanese infants were smaller than those in Europeans and Americans. Radiophotoluminescence glass dosemeters were used for dose measurement of a 3-y-old head-torso phantom. To examine the validity of the developed phantom, organ and effective doses by the in-phantom dosimetry system were compared with simulation values in a web-based CT dose calculation system (WAZA-ARI). The differences in doses between the two systems were <20 % at the doses of organs within scan regions and effective doses in head, chest and abdominopelvic CT examinations.

Reform and practice on teaching of medical statistics course based on web computing platform

Improving medical students' calculation ability in statistics has become the focus and difficulty of medical statistics course teaching, and its application relies heavily on statistical calculation software. In order to explore a new teaching approach which combined the advantages of traditional method and web-based calculation, we intended to build a web computing platform applying the Browser/Server (B/S) mode based on the campus network, and to revise the current syllabus of medical statistics, as well as to create a virtual weblab containing a typical case library. Practice has proved that the new mode effec-tively improved the practice capability of students and changed the traditional teacher-centered teaching approach. Key words: Web-based calculation; Medical statistics; Teaching reform

AtomicChargeCalculator: interactive web-based calculation of atomic charges in large biomolecular complexes and drug-like molecules.

BackgroundPartial atomic charges are a well-established concept, useful in understanding and modeling the chemical behavior of molecules, from simple compounds, to large biomolecular complexes with many reactive sites.Results This paper introduces AtomicChargeCalculator (ACC), a web-based application for the calculation and analysis of atomic charges which respond to changes in molecular conformation and chemical environment. ACC relies on an empirical method to rapidly compute atomic charges with accuracy comparable to quantum mechanical approaches. Due to its efficient implementation, ACC can handle any type of molecular system, regardless of size and chemical complexity, from drug-like molecules to biomacromolecular complexes with hundreds of thousands of atoms. ACC writes out atomic charges into common molecular structure files, and offers interactive facilities for statistical analysis and comparison of the results, in both tabular and graphical form.ConclusionsDue to high customizability and speed, easy streamlining and the unified platform for calculation and analysis, ACC caters to all fields of life sciences, from drug design to nanocarriers. ACC is freely available via the Internet at http://ncbr.muni.cz/ACC.Electronic supplementary materialThe online version of this article (doi:10.1186/s13321-015-0099-x) contains supplementary material, which is available to authorized users.

Effect of multiple allelic drop-outs in forensic RMNE calculations

Technological advances such as massively parallel sequencing enable increasing amounts of genetic information to be obtained from increasingly challenging samples. Certainly on low template, degraded and multi-contributor samples, drop-outs will increase in number for many profiles simply by analyzing more loci, making it difficult to probabilistically assess how many drop-outs have occurred and at which loci they might have occurred. Previously we developed a Random Man Not Excluded (RMNE) method that can take into account allelic drop-out while avoiding detailed estimations of the probability that drop-outs have occurred, nor making assumptions about at which loci these drop-outs might have occurred. The number of alleles that have dropped out, does not need to be exactly known. Here we report a generic Python algorithm to calculate the RMNE probabilities for any given number of loci. The number of allowed drop-outs can be set between 0 and twice the number of analyzed loci. The source code has been made available on https://github.com/fvnieuwe/rmne. An online web-based RMNE calculation tool has been made available on http://forensic.ugent.be/rmne. The tool can calculate these RMNE probabilities from a custom list of probabilities of the observed and non-observed alleles from any given number of loci. Using this tool, we explored the effect of allowing allelic drop-outs on the evidential value of random forensic profiles with a varying number of loci. Our results give insight into how the number of allowed drop-outs affects the evidential value of a profile and how drop-out can be managed in the RMNE approach.

Graft Survival Prediction Probability By Web-Based Calculation: Southern Mexican City Experience.

Graft Survival Prediction Probability By Web-Based Calculation: Southern Mexican City Experience.

Simple and Reliable Determination of the Modified Rankin Scale Score in Neurosurgical and Neurological Patients

The modified Rankin Scale (mRS) is a 6-level outcome scale used to assess level of function in neurological disease. We examined the interobserver reliability and intraobserver reliability of the mRS-9Q, a 9-question "yes/no" survey that measures the mRS score in neurosurgical and neurological patients. The mRS-9Q was administered in person or by telephone, and a Web-based tool was used to calculate the mRS score and to perform error checking. Part 1 compared the mRS-9Q with an mRS structured interview (n = 80). Part 2 compared mRS-9Q administration by telephone and by hard copy (n = 80). Part 3 compared mRS-9Q administration by an expert interviewer with administration by a nonexpert (n = 83). Part 4 examined reproducibility of the mRS-9Q over a 2-week period (n = 84). Agreement was very good in all study parts. In Part 1 (mRS-9Q vs mRS with structured interview), κ = 0.80 and κw = 0.96. In Part 2 (mRS-9Q telephone vs hard copy), κ = 0.83 and κw = 0.95. In Part 3 (mRS-9Q expert vs nonexpert), κ = 0.73 and κw = 0.93. In Part 4 (mRS-9Q reproducibility), κ = 0.76 and κw = 0.93. The mRS-9Q is a simple, easy-to-administer survey with a custom Web-based mRS calculation and error-checking tool. The mRS-9Q can reliably determine the mRS by hard copy survey or by telephone and can be administered by experts or nonmedical study personnel. The mRS-9Q can be used to measure functional outcome in a broad population of patients with neurosurgical and neurological diseases.