Wearable rehabilitation robots have become an important auxiliary tool in rehabilitation therapy, providing effective rehabilitation training and helping to recover damaged muscles and joints. In response to the difficulty of traditional control methods in solving various constraints in the trajectory tracking process of the Upper Limb Rehabilitation Robot (ULRR), this study uses model predictive control to study the trajectory tracking problem of the upper limb rehabilitation robot. Firstly, based on the Lagrangian dynamic model of wearable rehabilitation robots, an extended state space model with pseudo linearization of the system was established. Given the performance indicators and various constraints of the system, a corresponding model predictive controller is designed based on the Laguerre model to ensure system performance while greatly reducing the computational complexity of predictive control. Secondly, the stability of the model predictive controller is demonstrated, and a disturbance observer is introduced into the controller to achieve compensation for slow-varying perturbations; a joint space sliding mode variable is also introduced to achieve simultaneous tracking of the joint’s desired position and desired velocity. Finally, taking a planar two bar robot as an example, comparative simulation verification was conducted on unconstrained joint trajectory tracking and constrained joint trajectory tracking. The simulation results show that the model predictive controller can achieve simultaneous tracking of joint expected trajectory and expected speed while meeting various constraints. It has good effects in improving patient motion control ability and reducing patient fatigue, providing new research ideas and methods for the field of rehabilitation therapy.