Patients with hyperplastic scarring need to wear compression garments for long periods of time during treatment with compression therapy. Compression garment fabrics (CGFs) are prone to bacterial growth during use, leading to patient infections. It is essential to apply antibacterial functional finishing to the CGFs. In this study, antibacterial CGFs based on Ti3C2Tx and amino-functionalized silane coupling agent (3-aminopropyl) triethoxysilane composite material (APTES) were prepared by dip-coating method. The binding mechanism between the Ti3C2Tx-APTES and the CGF was explored, and the antibacterial rate, wash fastness, and wearability of the antibacterial fabric were investigated. The addition of APTES resulted in the formation of covalent bonds between the CGF and the antibacterial agent. The unwashed CGF exhibited antibacterial rates of 99.9% against Staphylococcus aureus (S. aureus, AATCC 25922) and 99.76% against Escherichia coli (E. coli, AATCC 6538), respectively. The wash fastness of antibacterial CGF met industry standard AA level, and the wearability of the treated fabric could basically satisfy daily wear requirements. The Ti3C2TX-APTES antimicrobial CGF prepared in this study provides an effective solution for the development of antimicrobial fabrics for sports and medical applications.