An innovative simultaneous space–time Hermite wavelet method has been developed to solve weakly singular fractional-order nonlinear integro-partial differential equations in one and two dimensions with a focus whose solutions are intermittent in both space and time. The proposed method is based on multi-dimensional Hermite wavelets and the quasilinearization technique. The simultaneous space–time approach does not fully exploit for time-fractional nonlinear weakly singular integro-partial differential equations. Subsequently, the convergence analysis is challenging when the solution depends on the entire time domain (including past and future time), and the governing equation is combined with Volterra and Fredholm integral operators. Considering these challenges, we use the quasilinearization technique to handle the nonlinearity of the problem and reconstruct it to a linear integro-partial differential equation with second-order accuracy. Then, we apply multi-dimensional Hermite wavelets as attractive candidates on the resulting linearized problems to effectively resolve the initial weak singularity at t=0. In addition, the collocation method is used to determine the tensor-based wavelet coefficients within the decomposition domain. We elaborate on constructing the proposed simultaneous space–time Hermite wavelet method and design comprehensive algorithms for their implementation. Specifically, we emphasize the convergence analysis in the framework of the L2 norm and indicate high accuracy dependent on the regularity of the solution. The stability of the proposed wavelet-based numerical approximation is also discussed in the context of fractional-order nonlinear integro-partial differential equations involving both Volterra and Fredholm operators with weakly singular kernels. The proposed method is compared with existing methods available in the literature. Specifically, we highlighted its high accuracy and compared it with a recently developed hybrid numerical approach and finite difference methods. The efficiency and accuracy of the proposed method are demonstrated by solving several highly intermittent time-fractional nonlinear weakly singular integro-partial differential equations.