Digoxin is one of the cardiac drugs that has been used since a very old time. It is used to treat many heart problems, including congestive heart failure, atrial fibrillation or flutter, and some cardiac arrhythmias. 1 It has mainly a weak positive inotropic effect as it increases myocardial contractility, stroke volume and blood pressure, and a negative chronotropic effect as it reduces heart rate.2The dosage applied is variable according to many personal variations such as renal function, age, body weight, etc. These factors are used to get optimal digoxin levels and decrease the risk of toxicity.3, 4Aim of the work This work aimed to study the incidence, clinical features, severity, management, prognostic factors and outcome of patients with acute digoxin poisoning admitted to Alexandria Main University Hospital (Alexandria Poison Center [APC] and ICU) for six months from the 1st November 2019 till the end of April 2020.