Anterior lesser curve seromyotomy with posterior truncal vagotomy is an alternative operation to the highly selective vagotomy. After preoperative gastric function testing, four dogs underwent an anterior lesser curve seromyotomy with posterior truncal vagotomy. However, a new prototype hand-held laser was used to perform the seromyotomy. This laser delivers 20 W and is small, light, and highly maneuverable. Results of the operation indicate that this laser was easy to use and yielded a very effective seromyotomy without complications. Peroperatively, the laser performed simultaneous section and hemostasis. Postoperatively, no significant acid production could be stimulated with either histamine, pentagastrin, or insulin. This operation yields good control of acid production and is faster and easier than the highly selective vagotomy. The hand-held waveguide CO2 laser may further facilitate the ease of this procedure.