The correct prediction of slowly varying wave drift loads is important for the mooring analysis of floating wind turbines (FWTs). However, present design analysis tools fail to correctly predict these loads in conditions with current and moderate and large waves. This paper presents a semi-empirical method to correct zero-current potential-flow quadratic transfer functions (QTFs) of horizontal wave drift loads in conditions with current and moderate and large waves. The method is applicable to column-stabilized types of substructures or semi-submersibles. In the first step, the potential-flow QTF is corrected for potential-flow wave–current effects by applying a heuristic method. Second, the generalized Exwave formula corrects for viscous drift effects. Viscous drift effects become important for moderate and large waves. Conditions with current in the same direction as the waves increase the viscous drift contribution further. The method is validated by comparing QTF predictions with empirical QTFs identified from model test data for the INO Windmoor semi. While potential-flow QTFs agree well with the empirical data for small seastates without current, they underestimate the wave drift loads for moderate and large seastates. Conditions with current increase the underestimation. The semi-empirical correction method significantly improves predictions.