Thermosyphon cooling system is an efficient data center cooling system for energy saving, but its commonly used free cooling technology (water-side economizer) has multiple heat transfer processes, which limit the utilization rate of natural cold sources. In this study, a hybrid thermosyphon cooling system (HTCS) that uses air economizers to assist the water-cooled row-level thermosyphons (terminal equipment part) for free cooling is proposed and investigated in a case data center. The previous cooling system (PCS) designed for this case data center, which used the same terminal equipment part and water-side economizers, is employed for comparison. To analyze the application potential of HTCS under different climate conditions, the energy models of HTCS and PCS are built for comparative studies on energy efficiency, environmental and economic potential in five typical climate cities. The results show that the HTCS has 575–4589 h longer free cooling periods than that of PCS in five typical climate cities, which leads to the annual energy consumption and Power Usage Efficiency of HTCS in most typical climate cities except Kunming are 13.7–24.7 % and 0.014–0.041 lower than those of PCS, respectively. Meanwhile, HTCS's annual CO2 emissions and life cycle costs are 344.2–1248.4 tons and 9.5–25.4 % lower than those of PCS in five typical climate cities except Kunming, which illustrates HTCS has good energy-saving and economic performance for data centers.
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