Experiment was conducted at Eastern Ethiopia of Harari Regional State of Erer Woldiya district, on farmers’ field for two years. The purpose of this study was to evaluate the effect of AFI and EFI with different irrigation intervals on growth component, yield and water use efficiency of tomato for two years 2018 and 2019. Accordingly plant height and NFPP were significantly (P<0.05) influenced by (IMs), whereas (IIs) had highly significant (P<0.01) effect on plant height and NFPP at both planting season. Total tomato yield was significantly influenced (P<0.05) by furrow IMs, but application frequency had highly significant (p<0.01). Water saved from treatment combination of AFI with 4, 6 and 8 days water IIs were 16%, 44% and 58% of total volume of irrigation water applied. Whereas water saved from EFI with 6 and 8 days of application was 33.3% and 50% respectively. AFI with 4 day water application shows little yield reduction as 4.97%, as compared with no stressed treatment; EFI with the same water application frequency). But AFI with 4 day II was saves 16% water from gross water applied for no stressed treatment EFI with 4 day. Treatment with 6 day II of AFI and, EFI were indicated that significant yield reduction as 15.74% and 14.61% respectively. But total amount of gross volume of irrigation water saved as 44 and 33.3% for AFI and EFI of the same II treatment. Crop water productivity (CWUE, IWUE and EWP) were highly significantly (P<0.01) influenced by both IMs and IIs. The result clearly confirms that, AFI had beneficial advantage over EFI on water saving and, the same consequent is happened for irrigation interval i.e. increasing interval from 4 day followed by 6 to 8 days increases water use efficiency of crop. Hence the result indicates that interaction effect of both factors (IMs and IIs) could save significant amount of irrigation water.