Urban microclimates directly impact the comfort of living environments and human health. This study focuses on a community within a university in Guangzhou and constructs a corresponding index system from the perspectives of regional climate analysis and architectural layout. It summarizes the key spatial elements influencing thermal comfort in living environments. The results indicate: (1) Guangzhou is located in a typical hot-summer and warm-winter region, characterized by a humid climate; (2) Using a university community in Guangzhou, Guangdong, as the research subject, a comprehensive comparison is made between simulated and empirically measured comfort evaluations. A related factor analysis is conducted to identify the key factors affecting wind efficiency. Among these, variables such as daily average temperature at Panyu Station, average wind speed at Panyu Station, and average building height 50 meters from the sampling point are found to have correlations with both simulated and measured thermal comfort indicators; (3) The analysis reveals significant differences between simulated and actual comfort, primarily due to the influences of architectural layouts, spatial arrangements, and real environmental factors.