Transformative technologies are the key to leading future technology innovation and economic development. However, with the exchange of technological knowledge among countries and the explosive growth of patented technology, the uneven flow and application of technology across geographic regions has become increasingly apparent, making it more and more difficult to track and absorb potentially transformative technology (PTT). As a proxy, the wake-up trajectories of the sleeping beauty patent family (SBPF) reflect the unbalanced distribution and application of PTT but still lack in-depth discussion. Therefore, this study adopted the parameter-free criteria to identify SBPFs and revealed the globalized diffusion patterns of PTT behind SBPFs' wake-up time and pace trajectories by taking "Polymerase Chain Reaction" technology as an example. The findings show that SBPFs’ wake-up has five-time and four-spatial trajectories and presents a small-scale diffusion in local areas. Meanwhile, PTT shows five diffusion patterns, achieving an unbalanced and centralized diffusion worldwide. These provide theoretical support for predicting the global development of PTT, and practical guidance for choosing technical direction, grasping market opportunities, and optimizing the national innovation environment.