Abstract The efficiency gains observed in a pair of closely spaced Darrieus turbines suggest the deployment of multiple turbines as an appealing solution for wind and, particularly, hydrokinetic applications, where the inflow direction is constant. The present study develops some design guidelines for closely spaced hydrokinetic Darrieus turbines by analyzing the trends of both power augmentation and wake development within arrays of multiple rotors, including not only an even number of rotors, which is the usual case in literature, but also an odd one. The analysis is carried out by means of two-dimensional Computational Fluid Dynamics simulations and includes not only the assessment of instantaneous blade forces but also locally sampled flow fields past each blade that allowed the reconstruction of dynamic polar data, contributing to a more comprehensive understanding of the physical mechanisms at play in such compact setups. The study demonstrates a consistent power augmentation mechanism across different layouts, even in the case of an odd number of rotors. This enhancement originates from flow blockage in the mutual interaction areas, favorably altering the inflow angle and subsequently increasing the angle of attack and lift generation. While this mechanism aligns with previous observations on arrays of counter-rotating pairs, its application to multiple turbines introduces complexities due to potential asymmetries in inflow, leading to an uneven power enhancement across turbines within the array. The identified efficiency improvement pattern suggests that maximizing leeward mutual interactions within an array of multiple Darrieus turbines would enhance the overall efficiency of the setup.