Event Abstract Back to Event Splenic phagocytes shape the immunity to Plasmodium infection in distinct but complimentary ways Henrique B. Da Silva1*, Philip J. Spence2, Sarah E. Reece3, Joanne Thompson3, Nico Van Rooijen4, Jean Langhorne2, Carlos E. Tadokoro5 and Maria R. D'Império Lima1 1 Universidade de São Paulo, Brazil 2 MRC National Institute for Medical Research, United Kingdom 3 University of Edinburgh, United Kingdom 4 Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Netherlands 5 Instituto Gulbenkian de Ciência, Portugal During experimental malaria, several changes in structure and cell numbers occur in spleen. The effects of these modifications on phagocytosis by spleen dendritic cells (DCs) and macrophage subsets are so far unknown, and the relative importance of this activity is not well understood. By using different in vivo and ex vivo approaches, we described some aspects of parasite phagocytosis and the implications to immune responses to infection. In naïve mice, DCs and F4/80+ red pulp macrophages (RpMOs) promptly recognized and internalized parasites, and enhanced the ability of making stable contacts with T and B cells inside spleen, respectively. The importance of DCs and RpMOs to activation of respectively T and B cells, as well as for survival after infection, was confirmed by depletion strategies. During the parasitemia peak, migrating inflammatory monocytes (MMs) were also able to phagocytize parasites, thus helping the parasitemia elimination observed in this model. However, these MMs were also crucial for controlling excessive CD4+ T cell activation by production of nitric oxide (NO); this control was necessary for full CD4+ T cell memory responses to parasite challenge. Thus, DCs, RpMOs and MMs contribute in distinct ways for parasite elimination and the induction of a massive, yet controlled, immune response to blood stage malaria. Acknowledgements We would like to extend our thanks to Rogério Silva do Nascimento, Jessica Souza, Mariana Franchi e Susana Caetano for technical assistance. We would also like to thank Dr. Michel Nussensweig, Dr. Mohammed Oukka and Dr. Vijay Kuchroo for donating mice for the research. Keywords: Plasmodium, Phagocytosis, intravital fluorescence microscopy, T cell activation, Immunoregulation Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Host-pathogen interactions Citation: Da Silva HB, Spence PJ, Reece SE, Thompson J, Van Rooijen N, Langhorne J, Tadokoro CE and D'Império Lima MR (2013). Splenic phagocytes shape the immunity to Plasmodium infection in distinct but complimentary ways. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00027 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Mr. Henrique B Da Silva, Universidade de São Paulo, São Paulo, Brazil, BorgesdaSilva.Henrique@mayo.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Henrique B Da Silva Philip J Spence Sarah E Reece Joanne Thompson Nico Van Rooijen Jean Langhorne Carlos E Tadokoro Maria R D'Império Lima Google Henrique B Da Silva Philip J Spence Sarah E Reece Joanne Thompson Nico Van Rooijen Jean Langhorne Carlos E Tadokoro Maria R D'Império Lima Google Scholar Henrique B Da Silva Philip J Spence Sarah E Reece Joanne Thompson Nico Van Rooijen Jean Langhorne Carlos E Tadokoro Maria R D'Império Lima PubMed Henrique B Da Silva Philip J Spence Sarah E Reece Joanne Thompson Nico Van Rooijen Jean Langhorne Carlos E Tadokoro Maria R D'Império Lima Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.