Interactions between feed size distribution and separation performance for hydrocyclones with different vortex finder diameters (Do) are crucial for hydrocyclone designs but not clearly understood. In this work, the optimum range of Do is numerically confirmed for a 50mm diameter hydrocyclone using computational fluid dynamics. Furthermore, effects of feed size distribution (FSD) on separation performance for hydrocyclones with different Do are discussed. For a given FSD, the lower limit of Do can be determined from the flow stability characterized by lower turbulence intensity and larger tangential velocity. Below the lower limit, a large proportion of fine particles report to the underflow. The upper limit can be determined from separation performance. Above the upper limit recovery to the underflow for coarse particles decreases drastically, which is caused by an outward shift of the locus of zero vertical velocity (LZVV) and an inward shift of particles equilibrium radius. For a given Do, FSD has no significant effects on partition curves when Do is in the optimum range. When Do is above the optimum range, both recovery to underflow for coarse particles and separation sharpness are decreased as the feed median size increases. In summary, when Do is in the optimum range, the hydrocyclone can adapt to different FSD to obtain the expected cut size by self-adjusting the LZVV and particles equilibrium radius. This method for determining the optimum range of Do is based on flow pattern characteristics and can be used as a universal tool for hydrocyclone design.