Acid Secretion Volume Research Articles

Evaluation of Antiulcer Activity of Different Extracts of Clitoria ternatea Leaves on Experimental Animals

We planned to evaluate the antiulcer effects of four different extract of Clitoria ternatea leaves. Gastric lesions were induced in rats by oral administration of Indomethacin (10 ml/kg). The antiulcer activity of Petroleum ether, Chloroform, Methanol and aqueous extract of Clitoria ternatea leaves (200 mg/kg and 400 mg/kg body wt) was compared with standard drugs. The parameters studied were ulcer index, gastric juice volume and pH of gastric juice. Clitoria ternatea leaves showed a dose dependent curative ratio compared to ulcer control groups. Pretreatment with extract displayed significant antiulcer activity which is almost equal to that of the standard drug. The volume of acid secretion, and ulcer index were decreased and pH of the gastric juice was increased compared to ulcer control group. The petroleum extract showed maximum antiulcer activity compared to other extract.

Evaluation of anti-ulcer activity of Samanea saman (Jacq) merr bark on ethanol and stress induced gastric lesions in albino rats

Objective:To evaluate the antiulcer activity of Samanea saman (Jacq) Merr bark on ethanol and stress induced gastric lesions in albino rats.Materials and Methods:Gastric lesions were induced in rats by oral administration of absolute ethanol (5 ml/kg) and stress induced by water immersion. The antiulcer activity of methanolic extract of Samanea saman (Jacq) Merr bark (100 mg/kg, 200 mg/kg, 400 mg/kg) was compared with standard drugs. The parameters studied were ulcer index, gastric juice volume, pH, free acidity and total acidity.Result:Samanea saman (Jacq) Merr showed a dose dependent curative ratio compared to ulcer control groups. The extract at 400 mg/kg showed significant anti ulcer activity which is almost equal to that of the standard drug in both models. The volume of acid secretion, total and free acidity was decreased and pH of the gastric juice was increased compared to ulcer control group.Conclusions:The present study indicates that Samanea saman (Jacq) Merr bark extracts have potential anti ulcer activity.